European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 281, P. 117027 - 117027
Published: Nov. 2, 2024
Language: Английский
Nature Nanotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Language: Английский
Citations
25
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
2
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Nov. 29, 2024
Language: Английский
Citations
13
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3643 - 3660
Published: April 15, 2024
The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum (ER) presents an opportunity to amplify synergistic effects chemotherapy and immunotherapy. In this study, we initially validated celastrol (CEL) as inducer immunogenic cell death (ICD) by promoting ER stress autophagy in colorectal cancer (CRC) cells. Subsequently, ER-targeted strategy was posited, involving codelivery CEL with PD-L1 small interfering RNAs (siRNA) using KDEL peptide-modified exosomes derived from milk (KME), enhance outcomes. Our findings demonstrate efficient transportation KME via Golgi-to-ER pathway. Compared their non-targeting counterparts, exhibited a significant augmentation CEL-induced ICD effect. Additionally, it facilitated release danger signaling molecules (DAMPs), thereby stimulating antigen-presenting function dendritic cells infiltration T into tumor. Concurrently, delivery siRNA resulted downregulation both intracellular membrane protein expression, consequently fostering proliferation activity CD8+ Ultimately, formulation enhanced anti-tumor efficacy provoked immune responses against orthotopic tumors vivo. Collectively, robust provides encouraging approach for achieving potent chemoimmunotherapy.
Language: Английский
Citations
11
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2)
Published: Feb. 2, 2024
Abstract A significant number of nucleic acid therapies have been approved, highlighting the vast potential therapeutics. Although numerous delivery strategies investigated, and progress has made in systems, oral route still presents a obstacle. Recently, novel promising force emerged, namely Decoctosomes Bencaosomes, obtained from decoction natural herbs, which refers to boiled Chinese herbal medicines. The active components include small molecules, peptides, RNAs (sRNAs). sRNAs were first targets extensive research. Additionally, Bencaosomes proven effective several disease mouse models as artificially enhanced decoctosome products. This perspective summarizes development possible future directions two varieties nanoparticles that may open door new possibilities therapy.
Language: Английский
Citations
9
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1376 - 1376
Published: Oct. 26, 2024
Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the of a surfactant enabling their absorption across gut barrier. The emergence microemulsions (thermodynamically stable), nanoemulsions (kinetically self-emulsifying drug delivery systems added unique characteristics that suitable for prolonged storage controlled release. In 1990s, solid-phase were introduced to reduce leakage from nanoparticles prolong Manipulating structure emulsions solid lipid has enabled multifunctional loading therapeutic macromolecules such as proteins, nucleic acid, vaccines, etc. Phospholipids surfactants well-defined polar head carbon chain have been used prepare bilayer vesicles known liposomes niosomes, respectively. increasing knowledge targeting ligands external factors gain control over pharmacokinetics ever-increasing number synthetic are expected vesicular preferred choice encapsulation targeted agents. This review discusses different oil-based nanoparticulate drugs. salient features each system highlighted, special emphasis is given studies compare them.
Language: Английский
Citations
9
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(30)
Published: Aug. 17, 2024
Abstract Nucleic acid drugs are one of the hot spots in field biomedicine recent years, and play a crucial role treatment many diseases. However, its low stability difficulty target drug delivery bottlenecks restricting application. Hydrogels proven to be promising for improving nucleic drugs, reducing adverse effects rapid degradation, sudden release, unnecessary diffusion drugs. In this review, strategies loading hydrogels summarized various biomedical research, classify mechanism principles these strategies, including electrostatic binding, hydrogen bond based hydrophobic covalent binding indirect using carriers. addition, review also describes release photostimulation‐based enzyme‐responsive pH‐responsive temperature‐responsive release. Finally, applications future research directions delivering medicine discussed.
Language: Английский
Citations
6
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(10), P. 1415 - 1439
Published: Sept. 14, 2024
Nucleic acid-based therapies are promising advancements in medicine. They offer unparalleled efficacy treating previously untreatable diseases through precise gene manipulation techniques. However, the challenge of achieving targeted delivery to specific cells remains a significant obstacle.
Language: Английский
Citations
3
European Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 190, P. 106523 - 106523
Published: July 8, 2023
The oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for the treatment colon related diseases has been focus increasing attention over last years. However, major disadvantage these macromolecules is their degradation propensity in liquid state which can lead to undesirable complete loss function. Therefore, increase stability biologic reduce propensity, formulation techniques solidification be performed obtain a stable solid dosage forms administration. Due fragility, stress exerted on during reduced with incorporation stabilizing excipients into formulation. This review focuses state-of-the-art required form use suitable adequate stabilization upon solidification. solidifying processes discussed within this are spray drying, freeze bead coating also other electro spraying, vacuum- supercritical fluid drying. Further, site absorption both healthy diseased critically reviewed possible systems discussed.
Language: Английский
Citations
7
Science China Materials, Journal Year: 2024, Volume and Issue: 67(8), P. 2393 - 2413
Published: July 12, 2024
Citations
2