MODERN TREATMENT OF SCAR DEFORMATION OF TISSUE DOI
P. G. Kogan, K. I. Khorak, D. G. Parfeev

et al.

Medical & pharmaceutical journal Pulse, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 50

Published: Oct. 20, 2024

The problem of scar treatment is one the most widespread in modern medicine. Treatment formations difficult tasks, as there no single standard that favorable terms efficacy and safety despite active development this area research. Currently, conservative methods tissue deformities such corticosteroid administration, botulinum therapy, cryotherapy, microneedling, well surgical excision combination with therapeutic are widely used, due to which result achieved. This study devoted various correction hypertrophic keloid scars becoming medicine, their comparison identification important advantages disadvantages order choose effective technique. Currently used allow cope formations, but high incidence side effects, a tendency search for combined use each them, including prevent recurrences achieve pronounced cosmetic effect satisfaction among patients. Thanks constant medicine improvement methods, patient can receive personalized approach guaranteed reduce aesthetic discomfort existing pathology, main aspect correction.

Language: Английский

Quercetin-encapsulated GelMa Hydrogel Microneedle Reduces Oxidative Stress and Facilitates Wound Healing DOI Creative Commons
Yi Yi, Zihui Yang, Chuchao Zhou

et al.

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100030 - 100030

Published: Jan. 6, 2024

Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity may have distinctive effect on healing. We designed constructed gelatin methacryloyl (GelMa) MNs carrying (Q-MNs). In vitro, the physical properties, cell safety, migration, angiogenesis, collagen formation, oxidative stress levels, were performed to characterize Q-MNs. vivo, full-thickness skin models established evaluate re-epithelialization impact of control, MN, Q-MN groups. The Q-MNs mechanically strong enough penetrate sustained possessed good biocompatibility. Moreover, evidently facilitated both in vitro promoted formation neo-angiogenesis, reduction levels. could motivate with enhanced vascularization decreased thus providing feasible strategy

Language: Английский

Citations

23

Emerging biomedical technologies for scarless wound healing DOI Creative Commons
Xinyue Cao,

Xiangyi Wu,

Yuanyuan Zhang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 449 - 477

Published: Sept. 11, 2024

Language: Английский

Citations

6

Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery DOI Creative Commons
Sofia Brito, Moo Jun Baek, Bum‐Ho Bin

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1403 - 1403

Published: Oct. 31, 2024

Several industries are increasingly focused on enhancing the delivery of active ingredients through skin to optimize therapeutic outcomes. By facilitating penetration barrier, these enhancers can significantly improve efficacy various formulations, ranging from skincare products agents targeting systemic circulation. As understanding physiology and mechanisms drug absorption deepen, adopting permeation more widely, ultimately leading better patient outcomes expanded treatment options. However, structure physiological function vary according different factors, such as area body between individuals. These variations, along with external environmental exposures, aging pathological conditions, introduce complexities that must be carefully considered when designing effective systems. Considering intricacies physiology, tailoring systems account for regional differences, individual variability, changes induced by factors or disease is critical optimizing This review discusses features structure, pathologies, well application in contexts. Furthermore, it addresses use animal models transdermal dermatological studies, latest developments this field.

Language: Английский

Citations

5

Skin microincision technique to enhance drug penetration for the treatment of keloid and hypertrophic scars DOI Creative Commons

Elisa Vettorato,

Paola Volontè, Umberto M. Musazzi

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125259 - 125259

Published: Jan. 1, 2025

Language: Английский

Citations

0

MXene-derived Multifunctional Biomaterials: New Opportunities for Wound Healing DOI Creative Commons
Dong Luo, Huiqi Zhang, Xinyang Xuanyuan

et al.

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

The process of wound healing is frequently impeded by metabolic imbalances within the microenvironment. MXenes exhibit exceptional biocompatibility, biodegradability, photothermal conversion efficiency, conductivity, and adaptable surface functionalization, demonstrating marked potential in development multifunctional platforms for healing. Moreover, integration with other bioactive nanomaterials has been shown to enhance their therapeutic efficacy, paving way innovative approaches In this review, we provide a systematic exposition mechanisms through which facilitate offer comprehensive analysis current research landscape on MXene-based composites field. By delving into latest scientific discoveries, identify existing challenges future trajectories advancement MXenes. Our evaluation aims insightful guidance formulation more effective strategies.

Language: Английский

Citations

0

Metal–organic framework microneedles for precision transdermal drug delivery: design strategy and therapeutic potential DOI

Yutong Jing,

Xueting Liu,

Yajing Zhu

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review explores the synergistic potential of MOF-based MNs and details strategies for integrating MOFs various guest molecules within into to enhance transdermal therapeutic applications.

Language: Английский

Citations

0

Glutamic acid-loaded separable microneedle composite for long-acting hair regeneration treatment DOI Creative Commons

Bricard Mbituyimana,

Lina Fu,

Hao Wang

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)

Published: Feb. 26, 2025

Language: Английский

Citations

0

Endothelial Dysfunction in Keloid Formation and Therapeutic Insights DOI

Junxian Wen,

Zhijin Li, Yingrou Tan

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0

Polymeric Microneedles for Biomedical Applications: Innovations in Transdermal Drug Delivery and Biosensing Technologies DOI
Wendel A. Alves, Jose E. U. Rojas,

Ana C. H. Castro-Kochi

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0

Oregano essential oil-infused mucin microneedle patch for the treatment of hypertrophic scar DOI
Ayesha Younas, Muhammad Asad,

Xiangling Wan

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124748 - 124748

Published: Sept. 1, 2024

Language: Английский

Citations

3