Cannabis and mental illness: a review

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2018, Volume and Issue: 269(1), P. 107 - 120

Published: Dec. 19, 2018

Language: Английский

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Lower-Risk Cannabis Use Guidelines (LRCUG) for reducing health harms from non-medical cannabis use: A comprehensive evidence and recommendations update

International Journal of Drug Policy, Journal Year: 2021, Volume and Issue: 99, P. 103381 - 103381

Published: Aug. 28, 2021

Cannabis use is common, especially among young people, and associated with risks for various health harms. Some jurisdictions have recently moved to legalization/regulation pursuing public goals. Evidence-based 'Lower Risk Use Guidelines' (LRCUG) recommendations were previously developed reduce modifiable risk factors of cannabis-related adverse outcomes; related evidence has evolved substantially since. We aimed review new scientific develop comprehensively up-to-date LRCUG, including their recommendations, on this basis. Targeted searches literature (since 2016) main outcomes by the user-individual conducted. Topical areas informed previous LRCUG content expanded upon current evidence. Searches preferentially focused systematic reviews, supplemented key individual studies. The results evidence-graded, topically organized narratively summarized; through an iterative expert consensus development process. A substantial body cannabis use-related harms identified varying quality. Twelve substantive recommendation clusters three precautionary statements developed. In general, suggests that individuals can if they delay onset until after adolescence, avoid high-potency (THC) products high-frequency/-intensity use, refrain from smoking-routes administration. While people are particularly vulnerable harms, other sub-groups (e.g., pregnant women, drivers, older adults, those co-morbidities) advised exercise particular caution risks. Legal/regulated should be used where possible. result in outcomes, mostly higher-risk use. Reducing help offer one targeted intervention component within a comprehensive approach They require effective audience-tailoring dissemination, regular updating as become available, evaluated impact.

Language: Английский

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Cannabis Use and the Risk for Psychosis and Affective Disorders

Journal of Dual Diagnosis, Journal Year: 2019, Volume and Issue: 16(1), P. 22 - 42

Published: Oct. 24, 2019

Objective: This review discusses the relationship between cannabis use and psychotic, bipolar, depressive, anxiety disorders, as well suicide. It summarizes epidemiological evidence from cross-sectional long-term prospective studies considers possible etiological mechanisms. Methods: Systematic reviews methodologically robust in field (from inception to February 2019) were identified using a comprehensive search of Medline, PsychINFO, Embase summarized narrative synthesis. Results: Consistent evidence, both observational experimental studies, has confirmed important role initiation persistence psychotic disorders. The size effect is related extent use, with greater risk for early high-potency varieties synthetic cannabinoids. Accumulating suggests that frequent also increases mania However, on depression less clear findings are contradictory only few studies. Furthermore, common mental disorders may involve reverse causality, reported lead consumption some Pathogenetic mechanisms focus tetrahydrocannabinol (THC, main psychoactive ingredient cannabis) interacting genetic predisposition perhaps other environmental factors. Cannabidiol (CBD), traditional cannabis, ameliorates psychotogenic effects THC but absent increasingly available. Conclusions: heavy high-THC/low-CBD types psychosis sufficiently strong merit public health education. Evidence similar smaller suicide growing, not convincing anxiety. There much current interest possibility CBD be therapeutically useful.

Language: Английский

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Modifiable risk and protective factors for anxiety disorders among adults: A systematic review

Psychiatry Research, Journal Year: 2019, Volume and Issue: 285, P. 112705 - 112705

Published: Dec. 4, 2019

Language: Английский

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Identifying risk-thresholds for the association between frequency of cannabis use and development of cannabis use disorder: A systematic review and meta-analysis

Drug and Alcohol Dependence, Journal Year: 2022, Volume and Issue: 238, P. 109582 - 109582

Published: July 21, 2022

Language: Английский

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Rapid increase in the prevalence of cannabis use among people with depression in the United States, 2005–17: the role of differentially changing risk perceptions

Addiction, Journal Year: 2019, Volume and Issue: 115(5), P. 935 - 943

Published: Dec. 4, 2019

To estimate trends in the prevalence of cannabis use and risk perceptions from 2005 to 2017 among United States people with without depression.Linear time any, daily non-daily past 30-day perceived great associated regular (outcome variables) past-year depression were assessed using logistic regression survey year as predictor. All analyses adjusted for gender, age, race/ethnicity income; models assessing also risk.The States: National Survey on Drug Use Health, an annual cross-sectional survey, 2005-17 public data files.A total 728 691 aged ≥ 12 years.Self-report use.The month was higher those versus [e.g. any use: 18.94 8.67%; odds ratio (aOR) = 2.17 (95% confidence interval (CI) 1.92, 2.45)]. Any, increased 2017, yet increase (aORs 1.06 1.05; P 0.008) 1.10 1.07; 0.021) socio-demographic characteristics more rapid depression. Perception significantly lower (P < 0.001) decreased rapidly over study period depression, compared 0.89 0.92; 0.001).The approximately twice common People experienced a decrease perception risk, which may be related past-month this group.

Language: Английский

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Cannabis and Cannabinoids in Mood and Anxiety Disorders: Impact on Illness Onset and Course, and Assessment of Therapeutic Potential

American Journal on Addictions, Journal Year: 2019, Volume and Issue: 29(1), P. 9 - 26

Published: Oct. 2, 2019

Background and Objectives Cannabis use is common in people with mood anxiety disorders (ADs), rates of problematic are higher than the general population. Given recent policy changes favor cannabis legalization, it important to understand how cannabinoids may impact these disorders. We aimed assess effects on onset course depression, bipolar disorder, ADs, post‐traumatic stress disorder (PTSD), also explore therapeutic potential for Methods A systematic review literature was completed. The PubMed® database from January 1990 May 2018 searched. included longitudinal cohort studies, all studies using or a cannabinoid as an active intervention, regardless study design. Results Forty‐seven were included: 32 reported illness onset, nine course, six therapeutics. Cohort varied significantly design quality. suggests that linked poorer clinical PTSD, but this finding not clear depression (ADs). There have been few high‐quality pharmaceuticals settings. Conclusions Scientific Significance These conclusions limited by lack well‐controlled studies. suggest future research be directed toward high‐quality, prospective populations addition controlled constituents populations. (Am J Addict 2019;00:00–00)

Language: Английский

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Cannabis and Depression

Advances in experimental medicine and biology, Journal Year: 2020, Volume and Issue: unknown, P. 67 - 80

Published: Dec. 17, 2020

Language: Английский

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Trends in college students’ alcohol, nicotine, prescription opioid and other drug use after recreational marijuana legalization: 2008–2018

Addictive Behaviors, Journal Year: 2019, Volume and Issue: 102, P. 106212 - 106212

Published: Nov. 11, 2019

Language: Английский

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Directional Effects of Anxiety and Depressive Disorders with Substance Use: a Review of Recent Prospective Research

Current Addiction Reports, Journal Year: 2020, Volume and Issue: 7(3), P. 344 - 355

Published: July 14, 2020

Language: Английский

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