European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 261, P. 115884 - 115884
Published: Oct. 16, 2023
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113525 - 113525
Published: Aug. 29, 2022
The standard breast cancer therapy still faces major challenges due to non-specific tumor distribution and occurrence of dose-limiting adverse side-effects. Nanomedicine constitutes an appealing approach improve the therapeutic index different anti-cancer drugs. Given their biocompatibility, low-cost manufacture easy surface modification, lipid nanoparticles, such as solid nanoparticles (SLN), have a great potential for drug delivery in therapy. In this work, SLN entrapping antineoplastic Mitoxantrone (Mito) were developed functionalized with Disteroylphosphatidylethanolamine-poly(ethylene glycol)-folic acid (DSPE-PEG-FA) ligand blood circulation selectivity limit systemic Nanoparticles presented adequate size intravenous injection stable at least 6 months. Additionally, hemocompatibility was demonstrated. Moreover, able effect free drug, assessed by values IC50 apoptotic effects MCF-7 cells. enhanced cellular internalization demonstrated confocal microscopy flow cytometry studies. Finally, uptake found occur via macropinocytosis clathrin-mediated endocytosis, suggesting involvement (folate receptor) (FR)-mediated endocytosis. Overall these findings highlight that are efficient nanocarriers selective Mito
Language: Английский
Citations
47
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)
Published: Nov. 16, 2023
Lung cancer is the second most prevalent and leading cause of cancer-related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, radiotherapy are currently available as treatment methods. However, drug resistance a significant factor in failure lung treatments. Novel therapeutics have been exploited to address complicated mechanisms advancement nanomedicine extremely promising terms overcoming resistance. Nanomedicine equipped with multifunctional tunable physiochemical properties alignment tumor genetic profiles can achieve precise, safe, effective while minimizing or eradicating cancer. Here, this work reviews discovered for radiotherapy, outlines novel strategies development against This focuses on engineering design, customized delivery, current challenges, clinical translation application resistant
Language: Английский
Citations
36
Cancer Drug Resistance, Journal Year: 2023, Volume and Issue: 6(2), P. 390 - 415
Published: Jan. 1, 2023
Cancer is currently one of the most intractable diseases causing human death. Although prognosis tumor patients has been improved to a certain extent through various modern treatment methods, multidrug resistance (MDR) cells still major problem leading clinical failure. Chemotherapy refers and/or tissues drug, usually inherent or developed during treatment. Therefore, an urgent need research ideal drug delivery system overcome shortcoming traditional chemotherapy. The rapid development nanotechnology brought us new enlightenments solve this problem. novel nanocarrier provides considerably effective limitations chemotherapy other drugs resulting from systemic side effects such as resistance, high toxicity, lack targeting, and off-target. Herein, we introduce several MDR mechanisms discuss nanoparticle technology applied surmount cancer resistance. Nanomaterials contain liposomes, polymer conjugates, micelles, dendrimers, carbon-based, metal nanoparticles, nucleotides which can be used deliver chemotherapeutic drugs, photosensitizers, small interfering RNA (siRNA). This review aims elucidate advantages nanomedicine in overcoming latest developments.
Language: Английский
Citations
31
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(27)
Published: July 11, 2023
Abstract Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT‐induced may be potentially prevented by suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger FSP1 inhibition. For enhancement of strategy, photoresponsive nanocomplex, self‐assembled BODIPY‐modified poly(amidoamine) (BMP), utilized stably encapsulate the inhibitor (iFSP1) chlorin e6 (Ce6). The nanosystem intracellular delivery, penetration, accumulation inducers tumors light irradiation. presents high‐performance triggering immunogenic (ICD) vitro vivo. Importantly, nanoparticles increase tumor infiltration CD8 + T cells further enhance efficacy anti‐PD‐L1 immunotherapy. study suggests potential photo‐enhanced synergistic induction nanocomplexes
Language: Английский
Citations
29
European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 261, P. 115884 - 115884
Published: Oct. 16, 2023
Language: Английский
Citations
29