European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116909 - 116909
Published: Sept. 24, 2024
Language: Английский
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Language: Английский
Citations
4
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(27)
Published: July 11, 2023
Abstract Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT‐induced may be potentially prevented by suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger FSP1 inhibition. For enhancement of strategy, photoresponsive nanocomplex, self‐assembled BODIPY‐modified poly(amidoamine) (BMP), utilized stably encapsulate the inhibitor (iFSP1) chlorin e6 (Ce6). The nanosystem intracellular delivery, penetration, accumulation inducers tumors light irradiation. presents high‐performance triggering immunogenic (ICD) vitro vivo. Importantly, nanoparticles increase tumor infiltration CD8 + T cells further enhance efficacy anti‐PD‐L1 immunotherapy. study suggests potential photo‐enhanced synergistic induction nanocomplexes
Language: Английский
Citations
29
APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(7-8), P. 1019 - 1037
Published: April 14, 2024
Language: Английский
Citations
15
ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17267 - 17281
Published: June 13, 2024
Intrinsic or acquired resistance to chemical drugs severely limits their therapeutic efficacy in cancer treatment. Various intracellular antioxidant molecules, particularly glutathione (GSH), play a crucial role maintaining redox homeostasis by mitigating the overproduced reactive oxygen species (ROS) due rapid cell proliferation. Notably, these antioxidants also eliminate chemical-drug-induced ROS, eventually diminishing cytotoxicity and rendering them less effective. In this study, we combined erastin, GSH biosynthesis inhibitor, with 2'-deoxy-5-fluorouridine 5'-monophosphate sodium salt (FdUMP), an ROS-based drug, effectively disrupt reverse chemotherapy resistance. Therefore, efficient ferroptosis apoptosis were simultaneously induced for enhanced antitumor effects. Additionally, employed small interfering RNA targeting PD-L1 (siPD-L1) as third agent block immune-checkpoint recognition CD8
Language: Английский
Citations
14
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 16, 2024
Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the immune system against cancer. However, immunosuppressive tumor microenvironment (TIME) poses challenge to triggering strong responses with single treatment, thus limiting therapeutic effect immunotherapy. In this study, dual-targeted nano delivery (GOx@FeNPs) combined αPD-L1 checkpoint blocker inhibit colorectal (CRC) progression by mediating PTT, ferroptosis and anti-tumor response. Briefly, specific was achieved cyclic arginine glycyl aspartate (cRGD) peptide anisamide (AA) GOx@FeNPs had good photothermal realize PTT induce ICD, deplete glutathione (GSH) catalyze production reactive oxygen species (ROS) from endogenous H
Language: Английский
Citations
13
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2091 - 2112
Published: March 1, 2024
Abstract: Currently, cancer remains one of the most significant threats to human health. Treatment cancers challenging, despite implementation diverse therapies in clinical practice. In recent years, research on mechanism ferroptosis has presented novel perspectives for treatment. Ferroptosis is a regulated cell death process caused by lipid peroxidation membrane unsaturated fatty acids catalyzed iron ions. The rapid development bio-nanotechnology generated considerable interest exploiting iron-induced as new therapeutic target against cancer. This article provides comprehensive overview advancements at intersection and bionanotechnology. this respect, its relation are summarized. Furthermore, feasibility nano-drug delivery system based treatment introduced analyzed. Secondly, strategies inducing using nanodrug technology discussed, including promoting Fenton reactions, inhibiting glutathione peroxidase 4, reducing low levels, Xc − . Additionally, explores potential combined involving Finally, application prospects challenges nanoagents discussed. Keywords: cancers, ferroptosis, system,
Language: Английский
Citations
9
Exploration, Journal Year: 2023, Volume and Issue: 4(3)
Published: Nov. 23, 2023
Abstract Protein‐based drugs have shown unique advantages to treat various diseases in recent years. However, most protein therapeutics clinical use are limited extracellular targets with low delivery efficiency. To realize targeted delivery, a series of stimuli‐triggered nanoparticle formulations been developed improve efficiency and reduce off‐target release. These smart nanoparticles designed release cargo proteins response either internal or external stimuli at pathological tissues. In this way, varieties protein‐based including antibodies, enzymes, pro‐apoptotic can be effectively delivered desired sites for the treatment cancer, inflammation, metabolic diseases, so on minimal side effects. review, advances design nanomedicine different biomedical applications will discussed. A deeper understanding these emerging strategies helps develop more efficient systems future.
Language: Английский
Citations
19
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: June 12, 2024
Abstract Photoresponsive drug delivery systems (PDDSs) have emerged as a promising toolbox for delivery, offering precise control over the site, duration, and dosage of light‐triggered medication. It allows controlled release, photo‐triggered targeting, diagnosis, treatment, improving precision efficacy therapies various diseases. Despite progress in designing different PDDSs, clinical translation has been limited due to obstacles. Herein, this review article focuses on three critical challenges PDDSs: 1) accumulation at diseased lesions, 2) light irradiation, 3) penetration tissues. Also, summarizes discusses current advancements strategies address these challenges. Overall, it emphasizes need clarify from bench bedside develop enhance therapeutic outcomes, increase compatibility patient compliance, unlock possibilities therapies.
Language: Английский
Citations
8
Oncology Reports, Journal Year: 2024, Volume and Issue: 52(2)
Published: June 27, 2024
Language: Английский
Citations
5
Journal of Photochemistry and Photobiology C Photochemistry Reviews, Journal Year: 2024, Volume and Issue: 59, P. 100665 - 100665
Published: June 1, 2024
Language: Английский
Citations
5