Biophysical Reviews,
Journal Year:
2023,
Volume and Issue:
15(2), P. 163 - 181
Published: April 1, 2023
Neurodevelopmental
disorders
(NDDs)
and
cancer
share
proteins,
pathways,
mutations.
Their
clinical
symptoms
are
different.
However,
individuals
with
NDDs
have
higher
probabilities
of
eventually
developing
cancer.
Here,
we
review
the
literature
ask
how
shared
features
can
lead
to
different
medical
conditions
why
having
an
NDD
first
increase
chances
malignancy.
To
explore
these
vital
questions,
focus
on
dysregulated
PI3K/mTOR,
a
major
brain
cell
growth
pathway
in
differentiation,
MAPK,
critical
proliferation,
hallmark
Differentiation
is
governed
by
chromatin
organization,
making
aberrant
remodelers
highly
likely
agents
NDDs.
Dysregulated
organization
accessibility
influence
lineage
specific
types
at
embryonic
development
stages.
PAK1,
pivotal
roles
cancer,
also
regulates
MAPK.
We
review,
clarify,
connect
pathways
proliferation
differentiation
highlight
PAK1
role
MAPK
regulation.
Exactly
activation
controls
development,
remodeler
components,
e.g.,
BAF170
encoded
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: June 13, 2023
Abstract
Tumor
immunotherapy
exerts
its
anti-tumor
effects
by
stimulating
and
enhancing
immune
responses
of
the
body.
It
has
become
another
important
modality
therapy
with
significant
clinical
efficacy
advantages
compared
to
chemotherapy,
radiotherapy
targeted
therapy.
Although
various
kinds
tumor
immunotherapeutic
drugs
have
emerged,
challenges
faced
in
delivery
these
drugs,
such
as
poor
permeability
low
cell
uptake
rate,
had
prevented
their
widespread
application.
Recently,
nanomaterials
emerged
a
means
for
treatment
different
diseases
due
targeting
properties,
biocompatibility
functionalities.
Moreover,
possess
characteristics
that
overcome
defects
traditional
immunotherapy,
large
drug
loading
capacity,
precise
easy
modification,
thus
leading
wide
application
immunotherapy.
There
are
two
main
classes
novel
nanoparticles
mentioned
this
review:
organic
(polymeric
nanomaterials,
liposomes
lipid
nanoparticles)
inorganic
(non-metallic
metallic
nanomaterials).
Besides,
fabrication
method
nanoparticles,
Nanoemulsions,
was
also
introduced.
In
summary,
review
article
mainly
discussed
research
progress
based
on
past
few
years
offers
theoretical
basis
exploring
strategies
future.
Life,
Journal Year:
2023,
Volume and Issue:
13(2), P. 466 - 466
Published: Feb. 7, 2023
Cancer
is
a
fatal
disease
with
complex
pathophysiology.
Lack
of
specificity
and
cytotoxicity,
as
well
the
multidrug
resistance
traditional
cancer
chemotherapy,
are
most
common
limitations
that
often
cause
treatment
failure.
Thus,
in
recent
years,
significant
efforts
have
concentrated
on
development
modernistic
field
called
nano-oncology,
which
provides
possibility
using
nanoparticles
(NPs)
aim
to
detect,
target,
treat
diseases.
In
comparison
conventional
anticancer
strategies,
NPs
provide
targeted
approach,
preventing
undesirable
side
effects.
What
more,
nanoparticle-based
drug
delivery
systems
shown
good
pharmacokinetics
precise
targeting,
reduced
resistance.
It
has
been
documented
that,
cells,
promote
reactive
oxygen
species
(ROS)
production,
induce
cell
cycle
arrest
apoptosis,
activate
ER
(endoplasmic
reticulum)
stress,
modulate
various
signaling
pathways,
etc.
Furthermore,
their
ability
inhibit
tumor
growth
vivo
also
documented.
this
paper,
we
reviewed
role
silver
(AgNPs)
nanomedicine,
discussing
numerous
mechanisms
by
they
render
properties
under
both
vitro
conditions,
potential
diagnosis
cancer.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 12, 2024
Abstract
Cancer
treatment
faces
many
hurdles
and
resistance
is
one
among
them.
Anti-cancer
strategies
are
evolving
due
to
innate
acquired
capacity,
governed
by
genetic,
epigenetic,
proteomic,
metabolic,
or
microenvironmental
cues
that
ultimately
enable
selected
cancer
cells
survive
progress
under
unfavorable
conditions.
Although
the
mechanism
of
drug
being
widely
studied
generate
new
target-based
drugs
with
better
potency
than
existing
ones.
However,
broader
flexibility
in
resistance,
advanced
therapeutic
options
efficacy
need
be
explored.
Combination
therapy
an
alternative
a
success
rate
though
risk
amplified
side
effects
commonplace.
Moreover,
recent
groundbreaking
precision
immune
ways
overcome
has
revolutionized
anticancer
greater
extent
only
limitation
individual-specific
needs
further
attention.
This
review
will
focus
on
challenges
opted
withstand
current
therapies
at
molecular
level
also
highlights
emerging
-like
immunological,
stem
cell-based
may
prove
have
potential
challenge
problem
resistance.
Cancer Letters,
Journal Year:
2024,
Volume and Issue:
587, P. 216659 - 216659
Published: Feb. 15, 2024
Despite
the
challenges
posed
by
drug
resistance
and
side
effects,
chemotherapy
remains
a
pivotal
strategy
in
cancer
treatment.
A
key
issue
this
context
is
macroautophagy
(commonly
known
as
autophagy),
dysregulated
cell
death
mechanism
often
observed
during
chemotherapy.
Autophagy
plays
cytoprotective
role
maintaining
cellular
homeostasis
recycling
organelles,
emerging
evidence
points
to
its
significant
promoting
progression.
Cisplatin,
DNA-intercalating
agent
for
inducing
cycle
arrest,
encounters
treatments.
Recent
studies
have
shown
that
autophagy
can
contribute
cisplatin
or
insensitivity
tumor
cells
through
various
mechanisms.
This
be
mediated
protective
autophagy,
which
suppresses
apoptosis.
Additionally,
autophagy-related
changes
metastasis,
particularly
induction
of
Epithelial-Mesenchymal
Transition
(EMT),
also
lead
resistance.
Nevertheless,
pharmacological
strategies
targeting
regulation
apoptosis
offer
promising
avenues
enhance
sensitivity
therapy.
Notably,
numerous
non-coding
RNAs
been
identified
regulators
Thus,
therapeutic
associated
pathways
holds
potential
restoring
sensitivity,
highlighting
an
important
direction
future
clinical
research.
Drug Resistance Updates,
Journal Year:
2022,
Volume and Issue:
63, P. 100844 - 100844
Published: May 2, 2022
Selenium
is
an
essential
trace
element
that
crucial
for
cellular
antioxidant
defense
against
reactive
oxygen
species
(ROS).
Recently,
many
selenium-containing
compounds
have
exhibited
a
wide
spectrum
of
biological
activities
make
them
promising
scaffolds
in
Medicinal
Chemistry,
and,
particular,
the
search
novel
with
anticancer
activity.
Similarly,
certain
tellurium-containing
also
substantial
activities.
Here
we
provide
overview
seleno-
and
tellurocompounds
including
chemopreventive
activity,
or
pro-oxidant
modulation
inflammatory
processes,
induction
apoptosis,
autophagy,
inhibition
multidrug
efflux
pumps
such
as
P-gp,
cancer
metastasis,
selective
targeting
tumors
enhancement
cytotoxic
activity
chemotherapeutic
drugs,
well
overcoming
tumor
drug
resistance.
A
review
chemistry
most
relevant
resistant
cancers
presented,
paying
attention
to
synthesis
these
preparation
bioactive
selenium
tellurium
nanoparticles.
Based
on
data,
use
approach
development
strategies
can
drive
forward
therapies
adjuvants
current
drug-resistant
cancers.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 7605 - 7635
Published: Dec. 1, 2023
Small
interfering
RNA
(siRNA)
delivery
by
nanocarriers
has
been
identified
as
a
promising
strategy
in
the
study
and
treatment
of
cancer.
Short
nucleotide
sequences
are
synthesized
exogenously
to
create
siRNA,
which
triggers
interference
(RNAi)
cells
silences
target
gene
expression
sequence-specific
way.
As
nucleic
acid-based
medicine
that
gained
popularity
recently,
siRNA
exhibits
novel
potential
for
However,
there
still
many
obstacles
overcome
before
clinical
devices
can
be
developed.
In
this
review,
we
discuss
prospective
targets
drug
design,
explain
properties
benefits,
give
an
overview
current
therapeutics
Additionally,
introduce
chemical
modifications
systems
clinically
sophisticated
classify
bioresponsive
materials
release
methodical
manner.
This
review
will
serve
reference
researchers
developing
more
precise
efficient
targeted
systems,
promoting
ongoing
advances
applications.
