Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5632 - 5632

Published: May 22, 2024

Photothermal therapy (PTT) is a promising cancer modality with significant advantages such as precise targeting, convenient drug delivery, better efficacy, and minimal adverse effects. effectively absorbs the photothermal transducers in near-infrared region (NIR), which induces effect to work. Although PTT has role tumor therapy, it also suffers from low conversion efficiency, biosafety, incomplete elimination. Therefore, use of nanomaterials themselves photosensitizers, targeted modification improve targeting or combined other therapies can therapeutic effects reduce side Notably, noble metal have attracted much attention because they strong surface plasmon resonance an effective absorbance light at specific wavelengths. be used excellent photosensitizers mediate its efficiency. This paper provides comprehensive review key played by therapy. It describes major challenges encountered during implementation

Language: Английский

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The role of cancer-associated fibroblasts and exosomal miRNAs-mediated intercellular communication in the tumor microenvironment and the biology of carcinogenesis: a systematic review

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 26, 2024

Abstract CAFs (cancer-associated fibroblasts) are highly flexible cells of the cancer microenvironment. They produce extracellular matrix (ECM) constituents that form structure tumor stroma but also a source metabolites, growth factors, chemokines, and exosomes impact every aspect tumor, including its response to treatment. It is believed exosomal miRNAs facilitate intercellular signaling, which essential for development cancer. The role in microenvironment (TME) carcinogenesis reviewed this paper. preferred reporting items systematic reviews meta-analyses (PRISMA) 2020 guidelines were used perform review. Several databases, Web Science, Medline, Embase, Cochrane Library, Scopus, searched using following keywords: CAFs, CAF, cancer-associated fibroblasts, stromal miRNA, miRNAs, exosome similar terms. We identified studies investigating TME their carcinogenesis. A total 12,572 papers identified. After removing duplicates ( n = 3803), 8774 articles screened by title abstract. Of these, 421 excluded from further analysis. has been reported if not functioning correctly, may influence secretory phenotype tip contribute increased invasiveness, spread, decreased treatment efficacy, poorer prognosis. Under influence, normal fibroblasts (NFs) transformed into CAFs. Furthermore, they participate metabolic reprogramming, allows fast proliferation cell population, adaptation growing energy demands, capacity avoid immune system identification.

Language: Английский

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Utilizing Nanoparticles to Overcome Anti-PD-1/PD-L1 Immunotherapy Resistance in Non-Small Cell Lung cancer: A Potential Strategy

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2371 - 2394

Published: Feb. 1, 2025

Lung cancer is the leading cause of cancer-related mortality globally, with non-small cell lung (NSCLC) constituting 85% cases. Immune checkpoint inhibitors (ICIs) represented by anti-programmed death protein 1 (PD-1)/ programmed ligand (PD-L1) have emerged as a promising frontier in treatment, effectively extending survival patients NSCLC. However, efficacy ICIs exhibits significant variability across diverse patient populations, substantial proportion showing poor responsiveness and acquired resistance those initially responsive to treatments. With advancement nanotechnology, nanoparticles offer unique advantages tumor immunotherapy, including high permeability prolonged retention(EPR) effects, enhanced drug delivery stability, modulation inflammatory microenvironment(TME). This review summarizes mechanisms NSCLC, focusing on antigens loss defective antigen processing presentation, failure T priming, impaired migration infiltration, immunosuppressive TME, genetic mutations. Furthermore, we discuss how nanoparticles, through their intrinsic properties such EPR effect, active targeting shielding self-regulatory synergistic can potentiate reverse resistance. In conclusion, serve robust platform for ICIs-based NSCLC therapy, aiding overcoming challenges.

Language: Английский

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Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(4), P. 1742 - 1758

Published: Dec. 16, 2023

Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to activation cellular oxidative stress and immune responses. While role in promoting inflammation hepatocytes is well-established, its effects on tumors have remained unclear. In this study, we designed a novel Pt(IV) complex, OAP2, which composed oxaliplatin (Oxa) acetaminophen (APAP), enhance anti-tumor amplify response. Our findings demonstrate that OAP2 induces nuclear damage, resulting production DNA. Additionally, downregulates expression Sam50, promote mtDNA secretion, double-stranded accumulation ultimately synergistically activating intracellular cGAS-STING pathway. The induced by overcomes limitations Oxa STING pathway simultaneously promotes gasdermin-D-mediated cell pyroptosis. also dendritic maturation enhances quantity efficacy cytotoxic T cells, thereby inhibiting cancer proliferation metastasis. Briefly, our study introduces first small-molecule inhibitor regulates for active immunotherapy research, may provide creative idea targeting organelle therapy.

Language: Английский

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Neoantigen vaccine nanoformulations based on Chemically synthesized minimal mRNA (CmRNA): small molecules, big impact

npj Vaccines, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 18, 2024

Abstract Recently, chemically synthesized minimal mRNA (CmRNA) has emerged as a promising alternative to in vitro transcribed (IVT-mRNA) for cancer therapy and immunotherapy. CmRNA lacking the untranslated regions polyadenylation exhibits enhanced stability efficiency. Encapsulation of within lipid-polymer hybrid nanoparticles (LPPs) offers an effective approach personalized neoantigen vaccines with improved control over tumor growth. LPP-based delivery systems provide superior pharmacokinetics, stability, lower toxicity compared viral vectors, naked mRNA, or lipid that are commonly used delivery. Precise customization LPPs terms size, surface charge, composition allows optimized cellular uptake, target specificity, immune stimulation. CmRNA-encoded neo-antigens demonstrate high translational efficiency, enabling recognition by CD8 + T cells upon processing presentation. This perspective highlights potential benefits, challenges, future directions Circular RNAs IVT-mRNA. Further research is needed optimize vaccine design, delivery, safety assessment clinical trials. Nevertheless, LPP-CmRNA hold great advancing immunotherapy, paving way medicine.

Language: Английский

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Photodynamic Therapy in the Treatment of Cancer—The Selection of Synthetic Photosensitizers

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 932 - 932

Published: July 11, 2024

Photodynamic therapy (PDT) is a promising cancer treatment method that uses photosensitizing (PS) compounds to selectively destroy tumor cells using laser light. This review discusses the main advantages of PDT, such as its low invasiveness, minimal systemic toxicity and risk complications. Special attention paid photosensitizers obtained by chemical synthesis. Three generations are presented, starting with first, based on porphyrins, through second generation, including modified chlorins, 5-aminolevulinic acid (ALA) derivative hexyl aminolevulinate (HAL), third which use nanotechnology increase selectivity therapy. In addition, current research trends highlighted, search for new can overcome limitations existing therapies, heavy-atom-free nonporphyrinoid photosensitizers, antibody–drug conjugates (ADCs) or near-infrared (NIR) absorption peak. Finally, prospects development PDTs taking into account advances in biomedical engineering. The references include both older newer works. many cases, when writing about given group first- second-generation publications used because properties described therein have not changed over years. Moreover, articles provide information serves an introduction drugs.

Language: Английский

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IL-12-Overexpressed Nanoparticles Suppress the Proliferation of Melanoma Through Inducing ICD and Activating DC, CD8+ T, and CD4+ T Cells

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2755 - 2772

Published: March 1, 2024

Purpose: The drug resistance and low response rates of immunotherapy limit its application. This study aimed to construct a new nanoparticle (CaCO 3 -polydopamine-polyethylenimine, CPP) effectively deliver interleukin-12 (IL-12) suppress cancer progress through immunotherapy. Methods: size distribution CPP zeta potential were measured using Malvern Zetasizer Nano-ZS90. morphology electrophoresis tentative delay analyzed JEM-1400 transmission electron microscope an ultraviolet spectrophotometer, respectively. Cell proliferation was by MTT assay. Proteins Western blot. IL-12 HMGB1 levels estimated ELISA kits. Live/dead staining assay performed Calcein-AM/PI kit. ATP production detected xenografts in vivo C57BL/6 mice. CD80 + /CD86 , CD3 /CD4 /CD8 flow cytometry. Results: could express EGFP or increase ROS levels. Laser treatment promoted CPP-IL-12 induced the number dead apoptotic cell. laser further enhance CALR extracellular decrease intracellular levels, indicating that it may induce immunogenic cell death (ICD). tumors weights laser-treated mice significantly reduced than controls. expression, expression DC from lymph glands, T cells spleen increased CPP-IL-12-treated compared with granzyme B, IFN-γ, TNF-α serum increased. Interestingly, local back inhibit growth distant untreated tumor. Conclusion: novel overexpress melanoma achieve inducing ICD, activating CD4 cell, enhancing function tumor-reactive CD8 cells. Keywords: immunotherapy, CaCO nanoparticle, interleukin-12, death, tumor therapy

Language: Английский

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Engineering nanoparticles for cancer immunotherapy: Current achievements, key considerations and future perspectives

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 486, P. 150356 - 150356

Published: March 14, 2024

Language: Английский

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Cocktail Cell‐Reprogrammed Hydrogel Microspheres Achieving Scarless Hair Follicle Regeneration

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 15, 2024

Abstract The scar repair inevitably causes damage of skin function and loss appendages such as hair follicles (HF). It is great challenge in wound that how to intervene formation while simultaneously remodeling HF niche inducing situ regeneration. Here, chemical reprogramming techniques are used identify a clinically cocktail (Tideglusib Tamibarotene) can drive fibroblasts toward dermal papilla cell (DPC) fate. Considering the advantage biomaterials tissue their regulation behavior may contributes cellular reprogramming, artificial seeding (AHFS) hydrogel microspheres, inspired by natural processes “seeding harvest”, constructed via using combination liposome nanoparticle drug delivery system, photoresponsive shell, positively charged polyamide modification, microfluidic photocrosslinking techniques. identified core nucleus AHFS. In vitro vivo studies show AHFS regulate fibroblast fate, induce fibroblast‐to‐DPC activating PI3K/AKT pathway, finally promoting healing regeneration inhibiting two‐pronged translational approach. conclusion, provides new effective strategy for functional wounds.

Language: Английский

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