FERREG: ferroptosis-based regulation of disease occurrence, progression and therapeutic response DOI Creative Commons
Yuan Zhou, Zhen Chen,

Mengjie Yang

et al.

Briefings in Bioinformatics, Journal Year: 2024, Volume and Issue: 25(3)

Published: March 27, 2024

Ferroptosis is a non-apoptotic, iron-dependent regulatory form of cell death characterized by the accumulation intracellular reactive oxygen species. In recent years, large and growing body literature has investigated ferroptosis. Since ferroptosis associated with various physiological activities regulated variety cellular metabolism mitochondrial activity, been closely related to occurrence development many diseases, including cancer, aging, neurodegenerative ischemia-reperfusion injury other pathological death. The regulation mainly focuses on three pathways: system Xc-/GPX4 axis, lipid peroxidation iron metabolism. genes involved in these processes were divided into driver, suppressor marker. Importantly, small molecules or drugs that mediate expression are often good treatments clinic. Herein, newly developed database, named 'FERREG', documented (i) providing data ferroptosis-related diseases occurrence, progression drug response; (ii) explicitly describing molecular mechanisms underlying each regulation; (iii) fully referencing collected cross-linking them available databases. Collectively, FERREG contains 51 targets, 718 regulators, 445 158 disease responses. can be accessed at https://idrblab.org/ferreg/.

Language: Английский

Inducing ferroptosis by traditional medicines: a novel approach to reverse chemoresistance in lung cancer DOI Creative Commons
Yumin Wang, Jing Hu, Joshua S. Fleishman

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Lung cancer is the leading cause of global cancer-related deaths. Platinum-based chemotherapy first-line treatment for most common type lung cancer, i.e., non-small-cell (NSCLC), but its therapeutic efficiency limited by chemotherapeutic resistance. Therefore, it vital to develop effective modalities that bypass molecular mechanisms associated with Ferroptosis a form non-apoptotic regulated cell death characterized iron-dependent lipid peroxidation (LPO). crucial proper efficacy cancer-associated chemotherapies. If targeted as novel mechanism, ferroptosis modulators present new opportunities increasing chemotherapy. Emerging studies have revealed pharmacological induction using natural compounds boosts in or drug-resistant cancer. In this review, we first discuss resistance (or chemoresistance) and introduce core behind ferroptosis. Then, comprehensively summarize small-molecule sourced from traditional medicines may boost anti-tumor activity current agents overcome NSCLC. Cumulatively, suggest ferroptosis-related anticancer could serve starting point NSCLC inducing ferroptosis, highlighting potential regimens used chemoresistance

Language: Английский

Citations

4
Daphnetin induces ferroptosis in ovarian cancer by inhibiting NAD(P)H:Quinone oxidoreductase 1 (NQO1) DOI Creative Commons
Ning Ma, Mengwen Zhang,

Jianqiang Hu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155876 - 155876

Published: July 14, 2024

Ferroptosis, an emerging nonapoptotic, modulated cell death process characterized by iron accumulation and subsequent lipid peroxidation, has been intimately implicated in the development progression of ovarian cancer (OC). Daphnetin (Daph), a natural product isolated from Daphne Korean Nakai, exhibits anticancer efficacy against various solid tumors. However, specific role potential mechanism underlying Daph-mediated modulation ferroptosis OC cells remain elusive.

Language: Английский

Citations

4
Ferroptosis at the nexus of metabolism and metabolic diseases DOI Creative Commons

S Y Li,

Guixiang Zhang,

Jiankun Hu

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(15), P. 5826 - 5852

Published: Jan. 1, 2024

Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a crucial regulator human physiology and pathology. Increasing evidence showcases reciprocal relationship between ferroptosis dysregulated metabolism, propagating pathogenic vicious cycle that exacerbates pathology diseases, particularly metabolic disorders. Consequently, there rapidly growing interest in developing ferroptosis-based therapeutics. Therefore, comprehensive understanding the intricate interplay metabolism could provide invaluable resource for mechanistic insight therapeutic development. In this review, we summarize important substances associated pathways initiation progression, outline cascade responses disease development, overview roles mechanisms introduce methods detection, discuss perspectives ferroptosis, which collectively aim to illustrate view basic, translational, clinical science.

Language: Английский

Citations

4
Terahertz Wave Desensitizes Ferroptosis by Inhibiting the Binding of Ferric Ions to the Transferrin DOI
Xiangji Li, Yangmei Li, Junxuan Xu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Ferroptosis is a classic type of programmed cell death characterized by iron dependence, which closely associated with many diseases such as cancer, intestinal ischemic diseases, and nervous system diseases. Transferrin (Tf) responsible for ferric-ion delivery owing to its natural Fe3+ binding ability plays crucial role in ferroptosis. However, Tf not considered druggable target ferroptosis-associated since systemic perturbation would dramatically disrupt blood homeostasis. Here, we reported nonpharmaceutical, noninvasive, Tf-targeted electromagnetic intervention technique capable desensitizing ferroptosis directivity. First, revealed that the THz radiation had significantly decrease affinity between via molecular dynamics simulations, modulation was strongly wavelength-dependent. This result provides theoretical feasibility modulation-based intervention. Subsequent extracellular cellular chromogenic activity assays indicated field at 8.7 μm (i.e., 34.5 THz) inhibited most bound Tf, wavelength good agreement simulated one. Then, functional demonstrated levels intracellular Fe2+, lipid peroxidation, malondialdehyde (MDA) were all reduced cells treated this wave. Furthermore, deposition, MDA disease model induced ischemia-reperfusion injury could be nearly eliminated same radiation, validating wave-induced desensitization vivo. Together, work preclinical exemplar irradiation-stimulated predicts an innovative, wave-based therapeutic method future.

Language: Английский

Citations

0
Ferroptosis-related signaling pathways in cancer drug resistance DOI Open Access
Yang Yang‐Hartwich,

Simin Yu,

Wanyao Liu

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 6, 2025

Ferroptosis is an iron-dependent form of programmed cell death induced by lipid peroxidation. This process regulated signaling pathways associated with redox balance, iron metabolism, and metabolism. Cancer cells' increased demand makes them especially susceptible to ferroptosis, significantly influencing cancer development, therapeutic response, metastasis. Recent findings indicate that cells can evade ferroptosis downregulating key related this process, contributing drug resistance. underscores the possibility modulating as approach counteract resistance enhance efficacy. review outlines involved in their interactions cancer-related pathways. We also highlight current understanding resistance, offering insights into how targeting provide novel approaches for drug-resistant cancers. Finally, we explore potential ferroptosis-inducing compounds examine challenges opportunities development evolving field.

Language: Английский

Citations

0
Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes DOI Open Access

Xiaochuan Dong,

Yanyan Xie, Wenxi Chen

et al.

Translational Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: 10, P. 7 - 7

Published: Jan. 1, 2025

Gastrointestinal adenocarcinomas (GIACs) are common malignant tumors with poor prognosis in the world. Ferroptosis, characterized by accumulation of intracellular iron and lipid reactive oxygen species, emerges as a pivotal process tumorigenesis cancer advancement. However, implications ferroptosis-related genes GIAC remain to be elucidated. This study aimed at exploring potential role on treatment GIAC. In our study, comprehensive clinical, transcriptomic, and/or genomic data were acquired from The Cancer Genome Atlas (TCGA), Cell Line Encyclopedia (CCLE), Genomics Drug Sensitivity (GDSC), Gene Expression Omnibus (GEO). We formulated ferroptosis-score within TCGA cohort through gene set variation analysis (GSVA) subsequently validated 4 GEO datasets (GSE84437, GSE17536, GSE103479, GSE19417). sensitivity immunotherapy efficacy analyzed GDSC dataset PRJEB25780 cohort, respectively. was significantly associated favorable overall survival both training [TCGA: P=0.003; hazard ratio (HR), 0.67, 95% confidence interval (95% CI): 0.52-0.87] across four validation cohorts (GSE17536: P=0.03; HR, 0.57, CI: 0.34-0.96; GSE19417: P=0.047; 0.53, 0.28-1.01; GSE84437: P=0.004; 0.68, 0.51-0.90; GSE103479: 0.55, 0.32-0.96). Furthermore, correlated activation DNA damage repair pathway resistance cisplatin. Notably, GIACs low ferroptosis-scores exhibited heightened expression immune checkpoint molecules such programmed death-(ligand) 1 cytotoxic T lymphocyte antigen-4, elevated densities tumor-infiltrating CD8+ cells, response pembrolizumab monotherapy. Our findings delineated clinical relevance demonstrated utility predicting effectiveness.

Language: Английский

Citations

0
Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring DOI
Mengzhu Li, Yuan Hu, Xiaoyan Wu

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0
Huang-qin decoction increases the sensitivity of EGFR-TKIs to NSCLC cells by regulating stat3/GPX4 to induce redox ratio and ROS to inhibit CSCs DOI Creative Commons
Yaya Yu,

Chenjing Lei,

Yanan Li

et al.

Journal of Traditional and Complementary Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin DOI Creative Commons
Ziwei Yang,

Tixin Han,

Ruibin Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 11, 2025

Ferroptosis, an iron-dependent form of regulated cell death, is characterized by the lethal accumulation lipid peroxides on cellular membranes. It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition cystine-glutamate antiporter, system Xc-, induces ferroptosis. Imidazole ketone erastin (IKE), inhibitor Xc- functional subunit solute carrier family 7 member 11 (SLC7A11), effective metabolically stable inducer ferroptosis with potential vivo applications. However, cells exhibited differential sensitivity to IKE-induced intrinsic factors determining remain be explored improve its efficacy. Bulk RNA-sequencing data from hepatocellular carcinoma (HCC) normal liver tissues were collected Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Differentially expressed genes identified intersected ferroptosis-related (FRGs) listed FerrDb database, yielding identification 13 distinct FRGs. A signature index model (Risk Score) was developed predict HCC prognosis. And SLC7A11 NAD(P)H quinone dehydrogenase 1 (NQO1) as candidate FRGs indicating poor prognosis HCC. Dicoumarol (DIC), NQO1, subsequently employed assess sensitizing effects IKE treatment. In lines subcutaneous xenograft model, combined suppression NQO1 significantly enhanced inhibitory effect inducing conclusion, our findings demonstrate that DIC sensitized Moreover, drugs enhance susceptibility could provide novel therapeutic strategies for treatment

Language: Английский

Citations

0
Oxidative Stress on the Ground and in the Microgravity Environment: Pathophysiological Effects and Treatment DOI Creative Commons
Xinyuan Zhang,

Huaiying Zhu,

Jinhua Zhang

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 231 - 231

Published: Feb. 18, 2025

With the continued exploration of universe, there is an increasingly urgent need to address health challenges arising from spaceflight. In space, astronauts are exposed radiation, confinement and isolation, circadian rhythm dysregulation, microgravity conditions that different those on Earth. These risk factors jeopardize astronauts' health, thus affecting quality space missions. Among these factors, gravitational changes influence balance between oxidation antioxidants, stimulating production reactive oxygen species (ROS), finally leading oxidative stress (OS). OS leads damage biomolecules such as lipids, proteins, DNA, which causes development various diseases. The occurrence increased in affects multiple systems, including musculoskeletal, cardiovascular, nervous, immune systems. this review, we discuss mechanisms OS, physiological effects systems caused by environment, potential treatments for OS. Finally, treatment strategies summarized, providing some promising approaches protecting future exploration.

Language: Английский

Citations

0