Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 87 - 109
Published: Jan. 1, 2025
Language: Английский
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: March 28, 2023
Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, nonalcoholic fatty liver disease, provides basis for common understanding these chronic diseases. In this study, we provide systematic review causes, mechanisms, treatments IR. The pathogenesis IR depends on genetics, obesity, age, drug effects. Mechanistically, any factor leading to abnormalities insulin signaling pathway leads host, including receptor abnormalities, disturbances internal environment (regarding inflammation, hypoxia, lipotoxicity, immunity), metabolic function organelles, other abnormalities. available therapeutic strategies are mainly exercise dietary habit improvement, chemotherapy based biguanides glucagon-like peptide-1, traditional Chinese medicine (e.g., herbs acupuncture) can also be helpful. Based current there still some vacancies follow up consider, is need define more precise biomarkers different lifestyle interventions, explore natural or synthetic drugs targeting treatment. This could enable treatment patients with multiple combined diseases, aim treating disease holistically reduce healthcare expenditures improve quality life extent.
Language: Английский
Citations
216
Sleep Medicine Reviews, Journal Year: 2022, Volume and Issue: 65, P. 101691 - 101691
Published: Aug. 31, 2022
Language: Английский
Citations
136
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1172 - 1172
Published: Jan. 21, 2022
Accumulating evidence suggests that the gut microbiome influences brain functions and psychological state of its host via gut–brain axis, dysbiosis has been linked to several mental illnesses, including major depressive disorder (MDD). Animal experiments have shown a depletion microbiota leads behavioral changes, is associated with pathological abnormal stress response impaired adult neurogenesis. Short-chain fatty acids such as butyrate are known contribute up-regulation brain-derived neurotrophic factor (BDNF), causes decreased levels BDNF, which could affect neuronal development synaptic plasticity. Increased permeability an influx microbial components lipopolysaccharides, resultant systemic inflammation may lead neuroinflammation in central nervous system. In light fact factors initiation exacerbation symptoms, this review summarizes current understanding molecular mechanisms involved MDD onset, discusses therapeutic potential probiotics, butyrate-producing bacteria, can mediate microbiota–gut–brain axis.
Language: Английский
Citations
80
Handbook of experimental pharmacology, Journal Year: 2021, Volume and Issue: unknown, P. 181 - 201
Published: Jan. 1, 2021
Language: Английский
Citations
58
Obesity, Journal Year: 2023, Volume and Issue: 31(4), P. 900 - 911
Published: March 2, 2023
Metabolic syndrome (MS) is a heterogeneous condition associated with increased cardiovascular risk. There growing evidence from experimental, translational, and clinical investigations that has suggested obstructive sleep apnea (OSA) prevalent incident components of MS itself. The biological plausibility supportive, primarily related to one the main features OSA, namely intermittent hypoxia: sympathetic activation hemodynamic repercussions, hepatic glucose output, insulin resistance through adipose tissue inflammation, pancreatic β-cell dysfunction, hyperlipidemia worsening fasting lipid profiles, reduced clearance triglyceride-rich lipoproteins. Although there are multiple pathways, relies mainly on cross-sectional data preventing any causality assumptions. overlapping presence visceral obesity or other confounders such as medications challenges ability understand independent contribution OSA MS. In this review, we revisit how OSA/intermittent hypoxia could mediate adverse effects parameters adiposity. Particular attention devoted discussing recent interventional studies. This review describes research gaps, in field, perspectives, need for additional high-quality studies addressing impact not only established but promising therapies OSA/obesity.
Language: Английский
Citations
39
Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1061 - 1061
Published: Feb. 7, 2023
Several epidemiological and clinical studies have suggested a relationship between obstructive sleep apnea (OSA) higher incidence or severity of cancer. This appears to be dependent on myriad factors. These include non-modifiable factors, such as age gender; modifiable preventable specific comorbidities (especially obesity), the use particular treatments, and, above all, histological type location Heterogeneity in OSA cancer is also related influences intermittent hypoxemia (a hallmark feature OSA), among others, metabolism microenvironment different types tumoral cells. The hypoxia inducible transcription factor (HIF-1α), molecule activated expressed situations hypoxemia, seems key enabling variety pathophysiological mechanisms that are becoming increasingly better recognized. appear operationally involved via alterations cellular functions (mainly involving immune system) molecular functions, by inducing modifications microbiome. This, turn, may individually collectively increase risk cancer, which then, further modulated genetic susceptibility individual. Here, we provide an updated brief review pathways been identified could explain We identify future challenges need overcome this intriguing field research.
Language: Английский
Citations
26
International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(15), P. 5004 - 5019
Published: Jan. 1, 2023
Background: Dietary fat intake is associated with an increased risk of colitis cancer (CAC). A high-fat diet (HFD) leads to systemic low-grade inflammation. The colon believed be the first organ suffering from inflammation caused by infiltration pro-inflammatory macrophages, and promotes CAC progression. We explored role HFD in driving altering gut microbial butyrate metabolism. Methods: Changes microbiota were investigated via treatment or fecal transplantation (FMT). underlying mechanisms further analyzing microbiota, metabolism, NLRP3 inflammasome tissues a mouse model. Results: accelerated progression mice, it could reversed broad-spectrum antibiotics (ABX). 16S-rRNA sequencing revealed that inhibited abundance butyrate-producing bacteria gut. level short-chain fatty acids (SCFAs), especially butyrate, mice treated was significantly reduced. In addition, exogenous M1 polarization proinflammatory aggravation intestinal inflammation, tumor growth induced HFD; NLRP3/Caspase-1 pathway activated also inhibited. vitro, macrophages lipopolysaccharide combined detect expression, results consistent those vivo experiments. Conclusion: drives colitis-associated tumorigenesis inducing dysbiosis inhibiting metabolism skew macrophage polarization. Exogenous feasible new strategy for CAC, has good prospect clinical application.
Language: Английский
Citations
26
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(4)
Published: Nov. 6, 2023
Abstract Background The comorbidity between diabetes mellitus and depression was revealed, increased the prevalence of depressive disorder, which ranked 13th in leading causes disability‐adjusted life‐years. Insulin resistance, is common mellitus, has risk symptoms both humans animals. However, mechanisms behind are multi‐factorial complicated. There still no causal chain to explain exactly. Moreover, Selective serotonin reuptake inhibitors, insulin metformin, recommended for treating mellitus‐induced depression, were found be a factor some complications diabetes. Aims Given these problems, many researchers made remarkable efforts analyze complicating from different aspects, including stress Hypothalamic–Pituitary–Adrenal axis, neurological system, oxidative stress, inflammation. Drug therapy, such as Hydrogen Sulfide, Cannabidiol, Ascorbic Acid Hesperidin, conducive alleviating depression. Here, we reviewed exact pathophysiology underlying disorder drug therapy. Methods review refers available literature PubMed Web Science, searching critical terms related Results In this review, that brain structure function, neurogenesis, brain‐derived neurotrophic glucose lipid metabolism involved comorbidity. Obesity might lead through reduced adiponectin leptin resistin. addition, therapy displayed could expand region potential Conclusions summarizes It also overviews with anti‐diabetic anti‐depressant effects.
Language: Английский
Citations
25
Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111251 - 111251
Published: Feb. 1, 2025
Language: Английский
Citations
1
Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)
Published: July 27, 2022
Gastrointestinal dysfunction is a common symptom of acute mountain sickness (AMS). The gut microbiota and γδ T cells play critical roles in intestinal disease. However, the mechanistic link between hypoxia-induced injury remains unclear. Here, we show that damage was significantly alleviated after depletion with antibiotics. Hypoxia modulated composition by promoting antimicrobial peptides angiogenin-4 secretions. abundance Clostridium mice hypoxia decreased, while Desulfovibrio increased. Furthermore, Desulfovibrio-derived phosphatidylethanolamine phosphatidylcholine promoted cell activation. In CD1d-deficient mice, levels intraepithelial IL-17A were decreased compared those wild-type under hypoxia. Mechanistically, phospholipid metabolites from are presented epithelial CD1d to induce proliferation IL-17A-producing cells, which aggravates injury. Gut microbiota-derived promote via CD1d-dependent suggesting can be targets for AMS therapy.
Language: Английский
Citations
32