A Bibliometric Analysis on the Research Trend of Exercise and the Gut Microbiome

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 903 - 903

Published: March 30, 2023

This article aims to provide an overview of research hotspots and trends in exercise the gut microbiome, a field which has recently gained increasing attention. The relevant publications on microbiome were identified from Web Science Core Collection database. publication types limited articles reviews. VOSviewer 1.6.18 (Centre for Technology Studies, Leiden University, Leiden, Netherlands) R package “bibliometrix” (R Foundation: Vienna, Austria) used conduct bibliometric analysis. A total 327 eligible eventually identified, including 245 original 82 time trend analysis showed that number rapidly increased after 2014. leading countries/regions this USA, China, Europe. Most active institutions Europe USA. Keyword relationship between disease, occurs throughout development research. interactions microbiota, exercise, status host’s internal environment, probiotics, are important facets as well. topic evolution presents multidisciplinary multi-perspective comprehensive Exercise might become effective intervention disease treatment by regulating microbiome. innovation exercise-centered lifestyle therapy may significant future.

Language: Английский

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Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice

Microbiological Research, Journal Year: 2023, Volume and Issue: 276, P. 127480 - 127480

Published: Aug. 23, 2023

Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Increasing evidence suggests therapeutic effects of melatonin on inflammation and gut microbiota remodelling. However, whether how alleviates CIH-induced dysfunction remains unclear. C57BL/6 J mice Caco-2 cell line were treated. We evaluated function spectrophotometrically using fluorescein isothiocyanate (FITC)-labelled dextran. Immunohistochemical immunofluorescent staining used detect morphological changes in the mechanical barrier. Western blotting (WB) quantitative real-time polymerase chain reaction (qRT-PCR) revealed expression tight junctions, signal transducer activator transcription 3 (STAT3) levels. 16 S rRNA analysis colonic contents microflora. Flow cytometry was cytokines Th17 cells with without supplementation. found that CIH could induce mucosal injury, including reduction number goblet decrease junction proteins. abundance beneficial genera Clostridium, Akkermansia, Bacteroides, while increasing pathogenic Desulfovibrio Bifidobacterium. Finally, facilitated differentiation via phosphorylation vitro elevated circulating pro-inflammatory cytokine vivo. Melatonin supplementation ameliorated dysbiosis, enteric polarization, reactions mentioned-above. attenuated by regulating flora epithelium integrity, polarization STAT3 signalling.

Language: Английский

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Extracellular Vesicles: A Crucial Player in the Intestinal Microenvironment and Beyond

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3478 - 3478

Published: March 20, 2024

The intestinal ecological environment plays a crucial role in nutrient absorption and overall well-being. In recent years, research has focused on the effects of extracellular vesicles (EVs) both physiological pathological conditions intestine. intestine does not only consume EVs from exogenous foods, but also those other endogenous tissues cells, even gut microbiota. alteration microbiota subsequently gives rise to changes organs systems, including central nervous system (CNS), namely microbiome-gut-brain axis, which exhibits significant involvement EVs. This review first an overview generation isolation techniques EVs, then mainly focuses elucidating functions derived various origins microenvironment, as well impacts altered microenvironment systems. Lastly, we discuss microbial cellular axis. enhances understanding specific roles system, thereby promoting more effective treatment strategies for certain associated diseases.

Language: Английский

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Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation

Journal of Food Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Sleep disturbances are increasingly prevalent, significantly impacting physical and mental health. Recent research reveals a bidirectional relationship between gut microbiota sleep, mediated through the microbiota–gut–brain axis. This review examines role of in sleep physiology explores how biotics, including probiotics, prebiotics, synbiotics, postbiotics, fermented foods, can enhance quality. Drawing from animal human studies, we discuss neurobiological mechanisms by which biotics may influence modulation neurotransmitters, immune responses, hormonal regulation. Key microbial metabolites, such as short‐chain fatty acids, highlighted for their supporting sleep‐related neurochemical processes. Additionally, this presents dietary strategies food processing technologies, like fermentation, innovative approaches enhancement. Although promising, available has limitations, small sample sizes, variability biotic strains dosages, reliance on subjective assessments. underscores need standardized protocols, objective assessments polysomnography, personalized interventions. Emerging findings highlight therapeutic potential improvement, though further large‐scale trials essential to refine strain selection, dosage, formulation. interdisciplinary exploration seeks advance food‐based interventions holistic managing disorders improving quality life.

Language: Английский

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Role of microbiota-gut-brain axis in Huntington’s disease and possible interventions

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 87 - 109

Published: Jan. 1, 2025

Language: Английский

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