Examining the healthy human microbiome concept

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

---

Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 771 - 791

Published: Feb. 1, 2025

Acute myocardial infarction (AMI) is a significant contributor to global morbidity and mortality. Allicin exhibits promising therapeutic potential in AMI as primary bioactive component derived from garlic; however, its underlying mechanisms remain incompletely elucidated. Our study induced mice by ligating the left coronary artery, administered allicin orally for 28 days. The cardioprotective effects of treatment were comprehensively assessed using echocardiography, histopathological examinations, intestinal barrier function, serum inflammatory factors. elucidated through analysis metagenomics metabolomics. Network pharmacology (NP) was used further investigate validate possible molecular allicin. findings revealed allicin's capacity ameliorate cardiac impairments, improve integrity, reduce IL-18 IL-1β levels after AMI. Further demonstrated that administration has flora disorder following modulating abundance beneficial bacteria, such g_Lactobacillus, g_Prevotella, g_Alistipes, g_Limosilactobacillus, while reducing harmful bacteria g_Parasutterella. Additionally, it ability enhance energy metabolism flexibility metabolites key enzymes associated with fatty acid metabolic pathway. Mechanistically, NP vivo experiments indicated might suppress pyroptosis response via blocked activation NF-κB-mediated NLRP3/Caspase-1/GSDMD Moreover, Spearman correlation suggested association between allicin-induced alterations microbiota function cytokines. alleviated injury reduced inhibiting pathway remodeling disturbance, improving disorder, enhancing barrier. These research offer novel perspective on value an adjunctive dietary supplement conventional treatments

Language: Английский

---

The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Nov. 7, 2023

Regulation of gut microbiota and its impact on human health is the theme intensive research. The incidence prevalence atrial fibrillation (AF) are continuously escalating as global population ages chronic disease survival rates increase; however, mechanisms not entirely clarified. It gaining awareness that alterations in assembly, structure, dynamics intimately engaged AF progression. Owing to advancements next-generation sequencing technologies computational strategies, researchers can explore novel linkages with genomes, transcriptomes, proteomes, metabolomes through parallel meta-omics approaches, rendering a panoramic view culture-independent microbial investigation. In this review, we summarized evidence for bidirectional correlation between microbiome. Furthermore, proposed concept "gut-immune-heart" axis addressed direct indirect causal roots microbiome AF. intricate relationship was unveiled generate innovative microbiota-based preventive therapeutic interventions, which shed light definite direction future experiments.

Language: Английский

---

Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Nov. 8, 2023

Abstract Background Gut microbiota imbalances have been suggested as a contributing factor to atrial fibrillation (AF), but the causal relationship is not fully understood. Objectives To explore relationships between gut and AF using Mendelian randomization (MR) analysis. Methods Summary statistics were from genome-wide association studies (GWAS) of 207 microbial taxa (5 phyla, 10 classes, 13 orders, 26 families, 48 genera, 105 species) (the Dutch Microbiome Project) two large meta-GWASs AF. The significant results validated in FinnGen cohort over 430,000 UK Biobank participants. Mediation MR analyses conducted for risk factors, including type 2 diabetes, coronary artery disease (CAD), body mass index (BMI), blood lipids, pressure, obstructive sleep apnea, potential mediation effect these factors Results Two causally associated with AF: species Eubacterium ramulus (odds ratio [OR] 1.08, 95% confidence interval [CI] 1.04–1.12, P = 0.0001, false discovery rate (FDR) adjusted p-value 0.023) genus Holdemania (OR 1.15, CI 1.07–1.25, 0.0004, FDR 0.042). Genus was incident Biobank. proportion via CAD 8.05% (95% 1.73% − 14.95%, 0.008), while on BMI 12.01% 5.17% 19.39%, 0.0005). Conclusions This study provided genetic evidence support mechanism role factors.

Language: Английский

---

The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4942 - 4942

Published: April 30, 2024

The Mediterranean diet (MD), rich in minimally processed plant foods and monounsaturated fats but low saturated fats, meat, dairy products, represents one of the most studied diets for cardiovascular health. It has been shown, from both observational randomized controlled trials, that MD reduces body weight, improves disease surrogates such as waist-to-hip ratios, lipids, inflammation markers, even prevents development fatal nonfatal disease, diabetes, obesity, other diseases. However, it is unclear whether offers benefits its individual components or a whole. Furthermore, limitations methodology studies meta-analyses have raised some concerns over potential benefits. also associated with characteristic changes intestinal microbiota, mediated through constituents. These include increased growth species producing short-chain fatty acids, Clostridium leptum Eubacterium rectale, Bifidobacteria, Bacteroides, Faecalibacterium prausnitzii species, reduced Firmicutes Blautia species. Such are known to be favorably inflammation, oxidative status, overall metabolic This review will focus on effects health action gut microbiota.

Language: Английский

---

Atractylenolide-I Alleviates Hyperglycemia-Induced Heart Developmental Malformations through Direct and Indirect Modulation of the STAT3 Pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155698 - 155698

Published: May 1, 2024

Language: Английский

---

Integration of polygenic and gut metagenomic risk prediction for common diseases

Nature Aging, Journal Year: 2024, Volume and Issue: 4(4), P. 584 - 594

Published: March 25, 2024

Abstract Multiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, a prospective population-based cohort with ~18 years e-health record follow-up, we investigated incremental combined value genomic gut metagenomic assessment compared conventional factors for predicting incident coronary artery disease (CAD), type 2 diabetes (T2D), Alzheimer prostate cancer. We found that polygenic scores (PRSs) improved prediction over all Gut microbiome predictive capacity baseline age CAD, T2D Integrated models PRSs, achieved highest performance diseases studied based on alone. The study demonstrates integrated PRSs improve chronic

Language: Английский

---

Antibiotic-perturbed microbiota and the role of probiotics

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 22(3), P. 155 - 172

Published: Dec. 11, 2024

Language: Английский

---

Gut microbiota and atrial cardiomyopathy

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria closely associated with atrial fibrillation its complications. Its etiology involves number factors, including genetic, infectious, immunologic, metabolic factors. Recent research has highlighted critical role gut microbiota in pathogenesis cardiomyopathy, this consistent gut–heart axis having major implications for cardiac health. The aim work to bridge knowledge gap regarding interactions between particular focus on elucidating mechanisms which dysbiosis may induce remodeling dysfunction. This article provides an overview changes composition effects metabolites. We also discuss how diet exercise affect influencing microbiota, as well possible future therapeutic approaches targeting axis. A healthy can prevent disease, but ecological lead variety symptoms, induction disease. pathophysiological aspects impact structure function, strategies exploring modulation treatment cardiomyopathy. Finally, we fecal transplantation oral probiotics or prebiotics. Our study highlights importance homeostasis cardiovascular health suggests that targeted interventions pave way innovative preventive

Language: Английский

---

Exploring the Axis of Gut Microbiota‐Inflammatory Cytokine‐Atrial Fibrillation in the Pathogenesis of Atrial Fibrillation

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(3)

Published: Feb. 1, 2025

ABSTRACT A relationship may exist between the gut microbiota, inflammatory factors and atrial fibrillation (AF); however, precise biological mechanisms linking these components remain uncertain.In this study, 211 single‐nucleotide polymorphisms associated with microbiota were collected from MiBioGen consortium. Summary data for AF sourced large‐scale genome‐wide association studies. Two‐step Mendelian randomization (MR) was applied to estimate possible mediating effect of cytokines on causality AF. MR confirmed effects class Lentisphaeria, family Bifidobacteriaceae, XIII, genus Anaerostipes , Howardella Intestinibacter Lachnospiraceae (NK4A136 group), Odoribacter Ruminococcus gnavus order Bifidobacteriales, Victivallales phylum Lentisphaerae prevention. Moreover, revealed role Fms‐related tyrosine kinase 3 ligand, interleukin‐6, interleukin‐7, leukaemia inhibitory factor receptor, sulfotransferase 1A1 tumour necrosis ligand superfamily member 12 in protecting against Fibroblast growth 5, interleukin‐2 receptor subunit β, had a causal effect, increasing risk. The mediation exploration indicated that indirect (FCS020 group) (id: 11314) mediated by interleukin‐18 OR 1.015 (95% confidence interval 1.000–1.037; proportion = 9.494%). This study supplies genetic insights into potential These associations are useful managing through manipulation microbiota.

Language: Английский

---