European Heart Journal Supplements,
Journal Year:
2024,
Volume and Issue:
26(Supplement_4), P. iv33 - iv40
Published: July 1, 2024
Abstract
The
primary
cellular
substrates
of
atrial
fibrillation
(AF)
and
the
mechanisms
underlying
AF
onset
remain
poorly
characterized
therefore,
its
risk
assessment
lacks
precision.
While
use
omics
may
enable
discovery
novel
factors
narrow
down
pathways
involved
in
pathogenesis,
work
is
far
from
complete.
Large-scale
genome-wide
association
studies
transcriptomic
analyses
that
allow
an
unbiased,
non-candidate-gene-based
delineation
molecular
changes
associated
with
humans
have
identified
at
least
150
genetic
loci
AF.
However,
only
few
these
been
thoroughly
mechanistically
dissected,
indicating
much
remains
to
be
discovered
for
targeted
diagnostics
therapeutics.
Metabolomics
metagenomics,
on
other
hand,
add
understanding
downstream
substrate
integrate
signalling
environmental
host
factors,
respectively.
These
two
rapidly
developing
fields
already
provided
several
correlates
prevalent
incident
require
additional
validation
external
cohorts
experimental
studies.
In
this
review,
we
take
a
look
recent
developments
genetics,
transcriptomics,
metabolomics
how
they
aid
improving
shed
light
into
leading
onset.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 771 - 791
Published: Feb. 1, 2025
Acute
myocardial
infarction
(AMI)
is
a
significant
contributor
to
global
morbidity
and
mortality.
Allicin
exhibits
promising
therapeutic
potential
in
AMI
as
primary
bioactive
component
derived
from
garlic;
however,
its
underlying
mechanisms
remain
incompletely
elucidated.
Our
study
induced
mice
by
ligating
the
left
coronary
artery,
administered
allicin
orally
for
28
days.
The
cardioprotective
effects
of
treatment
were
comprehensively
assessed
using
echocardiography,
histopathological
examinations,
intestinal
barrier
function,
serum
inflammatory
factors.
elucidated
through
analysis
metagenomics
metabolomics.
Network
pharmacology
(NP)
was
used
further
investigate
validate
possible
molecular
allicin.
findings
revealed
allicin's
capacity
ameliorate
cardiac
impairments,
improve
integrity,
reduce
IL-18
IL-1β
levels
after
AMI.
Further
demonstrated
that
administration
has
flora
disorder
following
modulating
abundance
beneficial
bacteria,
such
g_Lactobacillus,
g_Prevotella,
g_Alistipes,
g_Limosilactobacillus,
while
reducing
harmful
bacteria
g_Parasutterella.
Additionally,
it
ability
enhance
energy
metabolism
flexibility
metabolites
key
enzymes
associated
with
fatty
acid
metabolic
pathway.
Mechanistically,
NP
vivo
experiments
indicated
might
suppress
pyroptosis
response
via
blocked
activation
NF-κB-mediated
NLRP3/Caspase-1/GSDMD
Moreover,
Spearman
correlation
suggested
association
between
allicin-induced
alterations
microbiota
function
cytokines.
alleviated
injury
reduced
inhibiting
pathway
remodeling
disturbance,
improving
disorder,
enhancing
barrier.
These
research
offer
novel
perspective
on
value
an
adjunctive
dietary
supplement
conventional
treatments
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Nov. 7, 2023
Regulation
of
gut
microbiota
and
its
impact
on
human
health
is
the
theme
intensive
research.
The
incidence
prevalence
atrial
fibrillation
(AF)
are
continuously
escalating
as
global
population
ages
chronic
disease
survival
rates
increase;
however,
mechanisms
not
entirely
clarified.
It
gaining
awareness
that
alterations
in
assembly,
structure,
dynamics
intimately
engaged
AF
progression.
Owing
to
advancements
next-generation
sequencing
technologies
computational
strategies,
researchers
can
explore
novel
linkages
with
genomes,
transcriptomes,
proteomes,
metabolomes
through
parallel
meta-omics
approaches,
rendering
a
panoramic
view
culture-independent
microbial
investigation.
In
this
review,
we
summarized
evidence
for
bidirectional
correlation
between
microbiome.
Furthermore,
proposed
concept
"gut-immune-heart"
axis
addressed
direct
indirect
causal
roots
microbiome
AF.
intricate
relationship
was
unveiled
generate
innovative
microbiota-based
preventive
therapeutic
interventions,
which
shed
light
definite
direction
future
experiments.
Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Nov. 8, 2023
Abstract
Background
Gut
microbiota
imbalances
have
been
suggested
as
a
contributing
factor
to
atrial
fibrillation
(AF),
but
the
causal
relationship
is
not
fully
understood.
Objectives
To
explore
relationships
between
gut
and
AF
using
Mendelian
randomization
(MR)
analysis.
Methods
Summary
statistics
were
from
genome-wide
association
studies
(GWAS)
of
207
microbial
taxa
(5
phyla,
10
classes,
13
orders,
26
families,
48
genera,
105
species)
(the
Dutch
Microbiome
Project)
two
large
meta-GWASs
AF.
The
significant
results
validated
in
FinnGen
cohort
over
430,000
UK
Biobank
participants.
Mediation
MR
analyses
conducted
for
risk
factors,
including
type
2
diabetes,
coronary
artery
disease
(CAD),
body
mass
index
(BMI),
blood
lipids,
pressure,
obstructive
sleep
apnea,
potential
mediation
effect
these
factors
Results
Two
causally
associated
with
AF:
species
Eubacterium
ramulus
(odds
ratio
[OR]
1.08,
95%
confidence
interval
[CI]
1.04–1.12,
P
=
0.0001,
false
discovery
rate
(FDR)
adjusted
p-value
0.023)
genus
Holdemania
(OR
1.15,
CI
1.07–1.25,
0.0004,
FDR
0.042).
Genus
was
incident
Biobank.
proportion
via
CAD
8.05%
(95%
1.73%
−
14.95%,
0.008),
while
on
BMI
12.01%
5.17%
19.39%,
0.0005).
Conclusions
This
study
provided
genetic
evidence
support
mechanism
role
factors.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4942 - 4942
Published: April 30, 2024
The
Mediterranean
diet
(MD),
rich
in
minimally
processed
plant
foods
and
monounsaturated
fats
but
low
saturated
fats,
meat,
dairy
products,
represents
one
of
the
most
studied
diets
for
cardiovascular
health.
It
has
been
shown,
from
both
observational
randomized
controlled
trials,
that
MD
reduces
body
weight,
improves
disease
surrogates
such
as
waist-to-hip
ratios,
lipids,
inflammation
markers,
even
prevents
development
fatal
nonfatal
disease,
diabetes,
obesity,
other
diseases.
However,
it
is
unclear
whether
offers
benefits
its
individual
components
or
a
whole.
Furthermore,
limitations
methodology
studies
meta-analyses
have
raised
some
concerns
over
potential
benefits.
also
associated
with
characteristic
changes
intestinal
microbiota,
mediated
through
constituents.
These
include
increased
growth
species
producing
short-chain
fatty
acids,
Clostridium
leptum
Eubacterium
rectale,
Bifidobacteria,
Bacteroides,
Faecalibacterium
prausnitzii
species,
reduced
Firmicutes
Blautia
species.
Such
are
known
to
be
favorably
inflammation,
oxidative
status,
overall
metabolic
This
review
will
focus
on
effects
health
action
gut
microbiota.
Nature Aging,
Journal Year:
2024,
Volume and Issue:
4(4), P. 584 - 594
Published: March 25, 2024
Abstract
Multiomics
has
shown
promise
in
noninvasive
risk
profiling
and
early
detection
of
various
common
diseases.
In
the
present
study,
a
prospective
population-based
cohort
with
~18
years
e-health
record
follow-up,
we
investigated
incremental
combined
value
genomic
gut
metagenomic
assessment
compared
conventional
factors
for
predicting
incident
coronary
artery
disease
(CAD),
type
2
diabetes
(T2D),
Alzheimer
prostate
cancer.
We
found
that
polygenic
scores
(PRSs)
improved
prediction
over
all
Gut
microbiome
predictive
capacity
baseline
age
CAD,
T2D
Integrated
models
PRSs,
achieved
highest
performance
diseases
studied
based
on
alone.
The
study
demonstrates
integrated
PRSs
improve
chronic
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(3)
Published: Feb. 1, 2025
ABSTRACT
A
relationship
may
exist
between
the
gut
microbiota,
inflammatory
factors
and
atrial
fibrillation
(AF);
however,
precise
biological
mechanisms
linking
these
components
remain
uncertain.In
this
study,
211
single‐nucleotide
polymorphisms
associated
with
microbiota
were
collected
from
MiBioGen
consortium.
Summary
data
for
AF
sourced
large‐scale
genome‐wide
association
studies.
Two‐step
Mendelian
randomization
(MR)
was
applied
to
estimate
possible
mediating
effect
of
cytokines
on
causality
AF.
MR
confirmed
effects
class
Lentisphaeria,
family
Bifidobacteriaceae,
XIII,
genus
Anaerostipes
,
Howardella
Intestinibacter
Lachnospiraceae
(NK4A136
group),
Odoribacter
Ruminococcus
gnavus
order
Bifidobacteriales,
Victivallales
phylum
Lentisphaerae
prevention.
Moreover,
revealed
role
Fms‐related
tyrosine
kinase
3
ligand,
interleukin‐6,
interleukin‐7,
leukaemia
inhibitory
factor
receptor,
sulfotransferase
1A1
tumour
necrosis
ligand
superfamily
member
12
in
protecting
against
Fibroblast
growth
5,
interleukin‐2
receptor
subunit
β,
had
a
causal
effect,
increasing
risk.
The
mediation
exploration
indicated
that
indirect
(FCS020
group)
(id:
11314)
mediated
by
interleukin‐18
OR
1.015
(95%
confidence
interval
1.000–1.037;
proportion
=
9.494%).
This
study
supplies
genetic
insights
into
potential
These
associations
are
useful
managing
through
manipulation
microbiota.
Age-related
atrial
fibrillation
(AF)
is
a
common
condition
that
has
yet
to
be
fully
understood,
with
mechanisms
explain
its
development
under
investigation.
Notably,
cellular
senescence,
cardiac
fibrosis,
coronary
ischemia,
valvular
disease,
autonomic
dysfunction,
channelopathies,
and
immune
system
remodeling
are
processes
have
been
seen
occur
aging
ample
evidence
shown
their
association
the
of
AF.
Despite
robust
therapeutic
approaches,
incidence
AF
continues
rise,
suggesting
dynamic,
multi-faceted
interactions
leading
incompletely
understood.
One
newer
currently
being
investigated
gut
microbiome.
Although
more
research
needed
understand
impact
on
age-related
targets
for
therapies,
microbiome
promising
new
avenue
may
provide
future
benefits
in
prophylaxis
or
enhanced
management.
As
field
works
towards
developing
this
knowledge,
there
important
questions
answer
as
optimal
role
potential
targeting
therapies
risks
versus
they
provide.
This
commentary
first
summarizes
understood
contributing
AF,
which
then
followed
by
an
analysis
current
work
investigating
concludes
highlighting
notable
consider
relationship
