Interactions of antimony with biomolecules and its effects on human health

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 233, P. 113317 - 113317

Published: Feb. 16, 2022

Antimony (Sb) pollution has increased health risks to humans as a result of extensive application in diverse fields. Exposure different levels Sb and its compounds will directly or indirectly affect the normal function human body, whereas limited data simulation studies delay understanding this element. In review, we summarize current research on effects from perspectives. First, exposure pathways, concentration excretion are briefly introduced, several have revealed that high cause higher concentrations body tissues. Second, interactions between biomolecules other nonbiomolecules affected biochemical processes such gene expression hormone secretion, which vital for causing mechanisms. Finally, discuss at biological level small molecules individual. conclusion, increase risk disease by affecting cell signaling pathways. addition, appropriate form dose contribute inhibit development specific diseases. Key challenges gaps toxicity benefit mechanisms still hinder assessment also identified review. Systematic relationships process needed.

Language: Английский

---

Endoplasmic Reticulum Stress Contributes to Copper-Induced Pyroptosis via Regulating the IRE1α-XBP1 Pathway in Pig Jejunal Epithelial Cells

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(4), P. 1293 - 1303

Published: Jan. 25, 2022

Copper (Cu) is a common additive in food products, which poses potential concern to animal and human health when it excess. Here, we investigated the relationship between endoplasmic reticulum (ER) stress pyroptosis Cu-induced toxicity of jejunum vivo vitro. In experiments, excess intake dietary Cu caused ER cavity expansion, elevated fluorescence signals GRP78 Caspase-1, increased mRNA protein expression levels related pig jejunal epithelium. Simultaneously, similar effects were observed IPEC-J2 cells under treatment. Importantly, 4-phenylbutyric acid (ER inhibitor) MKC-3946 (IRE1α significantly inhibited stress-triggered IRE1α-XBP1 pathway, also alleviated cells. general, these results suggested that participated regulating epithelial via provided novel view into toxicology Cu.

Language: Английский

---

GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 234, P. 113413 - 113413

Published: March 16, 2022

Exposure to antimony (Sb), recently identified as a nerve pollutant, can result in neuron damage; but, associated-neurotoxicological mechanisms were still not clear. Herein, we assessed the role of ferroptosis Sb-mediated neurotoxicity and clarified underlying mechanism. Following Sb exposure, was significantly promoted vivo vitro. Moreover, following use ferrostatin-1 (fer-1) inhibit ferroptosis, Sb-induced PC12 cells effectively attenuated. accelerated lysosomal transport subsequent degradation glutathione peroxidase 4 (GPX4), resulting ferroptosis. Furthermore, chaperone-mediated autophagy (CMA) activated treatment with Sb, while inhibition CMA by associated protein 2 A (LAMP2A) knockdown attenuated GPX4 degradation. also increased expression chaperones heat shock cognate 70 (HSC70) 90 (HSP90) lysosome receptor LAMP2A, binding HSP90, HSC70, LAMP2A observed, indicating formation chaperone-GPX4 complex. Finally, overexpression protected from activation Sb-stimulated cytotoxicity. Collectively, our results provide original mechanism which triggers neurotoxicity, concluded that stimulates neuronal through CMA-mediated

Language: Английский

---

ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency

Environmental Pollution, Journal Year: 2023, Volume and Issue: 324, P. 121392 - 121392

Published: March 9, 2023

Language: Английский

---

Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 201, P. 105904 - 105904

Published: April 10, 2024

Language: Английский

---

The Role of Autophagy and Pyroptosis in Liver Disorders

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 6208 - 6208

Published: June 1, 2022

Pyroptosis is a programmed cell death caused by inflammasomes, which can detect cytosolic contamination or disturbance. In pyroptosis, caspase-1 caspase-11/4/5 activated, cleaving gasdermin D to separate its N-terminal pore-forming domain (PFD). The oligomerization of PFD forms macropores in the membrane, resulting swelling and membrane rupture. According different mechanisms, pyroptosis be divided into three types: canonical pathway-mediated non-canonical caspase-3-induced pyroptosis. has been reported play an important role many tissues organs, including liver. Autophagy highly conserved process eukaryotic cycle. It plays survival maintenance degrading organelles, proteins macromolecules cytoplasm. Therefore, dysfunction this involved variety pathological processes. recent years, autophagy their interactions have proven various physiological processes, gradually attracted more attention become research hotspot. review summarized liver disorders, analyzed related mechanism provide basis for future research.

Language: Английский

---

The role of ROS/p38 MAPK/NLRP3 inflammasome cascade in arsenic-induced depression-/anxiety-like behaviors of mice

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 261, P. 115111 - 115111

Published: June 7, 2023

Arsenic pollution in groundwater remains a serious public health concern around the world. Recent years, arsenic-related neurological and psychiatric disorders have been reported increasingly. However, exact mechanisms of it elusive. In this study, arsenic exposure through drinking water resulted depression-/anxiety-like behaviors mice accompanied by oxidative stress NOD-like receptor thermal protein domain associated 3 (NLRP3) inflammasome activation prefrontal cortex (PFC) hippocampus, two main affected areas found neurobehavioral disorders. Intervention NAC, ROS scavenger, diminished social behavior impairments as well generation NLRP3 activation. Further study revealed that was p38 MAPK signaling pathway mediated ROS-induced Overall, our findings suggested ROS/p38 MAPK/NLRP3 cascade involved arsenic-induced depression-/anxiety-disorders. Furthermore, NAC might be potential therapeutic agent for depression-/anxiety-disorders inhibiting both

Language: Английский

---

The mitochondria-targeted antioxidant MitoQ ameliorates inorganic arsenic-induced DCs/Th1/Th2/Th17/Treg differentiation partially by activating PINK1-mediated mitophagy in murine liver

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 277, P. 116350 - 116350

Published: April 22, 2024

Inorganic arsenic is a well-established environmental toxicant linked to acute liver injury, fibrosis, and cancer. While oxidative stress, pyroptosis, ferroptosis are known contributors, the role of PTEN-induced kinase 1 (PINK1)-mediated mitophagy in arsenic-induced hepatic immunotoxicity remains underexplored. Our study revealed that exposure prompts differentiation dendritic cells (DCs) T helper (Th) 1, Th2, Th17, regulatory (Treg) cells, alongside increased transcription factors cytokines. triggered redox imbalance, leading elevated alanine transaminase (ALT), hydrogen peroxide (H

Language: Английский

---

Evaluation of potential cardiotoxicity of ammonia: l-selenomethionine inhibits ammonia-induced cardiac autophagy by activating the PI3K/AKT/mTOR signaling pathway

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 233, P. 113304 - 113304

Published: Feb. 11, 2022

Ammonia is a major harmful gas in the environment of livestock and poultry. Studies have shown that excessive ammonia inhalation has adverse effects pig heart. However, mechanism ammonia-induced cardiac toxicity pigs not been reported. L-selenomethionine kind organic selenium (Se) which easily absorbed by body. Therefore, this study, twenty-four 125-day-old were randomly divided into 4 groups: C (control) group, A (ammonia) Se group (Se content: 0.5 mg kg-1), + group. The cardiotoxicity alleviating effect examined. results showed as follows: large number myocardial fiber edema cytoplasmic bleakness observed heart; mitochondrial autophagy observed; ATP content, ATPase activities hematological parameters decreased significantly; Endoplasmic reticulum stress (ERS) markers (GRP78, IRE1α, ATF4, ATF6, CHOP) significantly induced mRNA protein levels; PI3K/AKT/mTOR signaling pathway was activated; key genes proteins (Beclin-1, LC3, ATG3, ATG5) up-regulated. comparison between degree muscle somewhat relieved; level decreased; content increased levels ERS down-regulated; expression decreased. changes these indexes still different from those Our indicated supplementation inhibited activating pathway, confirmed could alleviate injury caused to certain extent. This study aims enrich toxicological provide valuable reference for future intervention toxicity.

Language: Английский

---

Integrating transcriptome and physiological analysis to reveal the essential responses of Daphnia magna to antimony trioxide nanoparticle

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 437, P. 129303 - 129303

Published: June 7, 2022

Language: Английский

---