Multivariate analysis of the molecular mechanism related to breast cancer and depression DOI Creative Commons
Hua Xie, Chen Ding, Qianwen Li

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 27, 2023

Abstract Background Breast cancer is a malignant disease that seriously affects women's health,there certain connection between depression and it, however, the mechanism of their interrelationship still unclear.This article aims to explore common genetic characteristics potential molecular mechanisms breast through multiple data sets. Methods Download related datasets from TCGA database NCBI GEO public database, use R package "Limma" analyze difference data, identify differentially expressed genes normal samples samples, Metascape for annotation visualization, carry out gene ontology (GO) analysis Kyoto Gene Genome Encyclopedia (KEGG) pathway genes, Random Forest SRC software was used random survival forest algorithm screen characteristic key co by were screened; In addition, CIBERSORT patients, Pearson correlation conducted on expression content immune cells, transcription regulatory factors predicted "RcisTarget"; The "pRRophic" predict drug sensitivity each sample; sets Molecular signatures GSVA comprehensively score set, evaluate biological functional changes different samples; Further differences in signaling pathways high low groups GSEA; A multivariate regression model constructed using Nomogram obtain miRNAs miRcode miRNA network visualized Cytoscape software. Results Through analysis, CCNB1, MLPH, PSME1 RACGAP1 screened as four depression, specific signal these analyzed, which regulated other mechanisms, suggesting they significantly level involved progression These are affect have strong with cells; showed it treatment cancer; clinical information will be construct predictive effect prognosis cancer. Conclusion Our work has found comorbidity depression. It first time occurrence, progress, two diseases factors, thus can biomarkers or therapeutic targets diseases.

Language: Английский

Heavy metal stress and mitogen activated kinase transcription factors in plants: Exploring heavy metal‐ROS influences on plant signalling pathways DOI
Lee‐Ann Niekerk, Arun Gokul, Gerhard Basson

et al.

Plant Cell & Environment, Journal Year: 2024, Volume and Issue: 47(8), P. 2793 - 2810

Published: April 23, 2024

Due to their stationary nature, plants are exposed a diverse range of biotic and abiotic stresses, which heavy metal (HM) stress poses one the most detrimental targeting plant processes. HMs instigate overproduction reactive oxygen species (ROS), mitigate adverse effects ROS, induce multiple defence mechanisms. Besides negative implications these molecules play multitude signalling roles in plants, acting as central player complex network cells. One ROS-associated mechanisms is mitogen-activated protein kinase (MAPK) cascade, pathway transduces extracellular stimuli into intracellular responses. Plant MAPKs have been implicated involved response, phytohormone regulation, cell cycle cues. However, influence various on MAPK activation has not well documented. In this review, we address summarise several aspects related HM-induced ROS signalling. Additionally, touch how signals activate cascade downstream transcription factors that responses HMs. Moreover, propose workflow could characterise genes associated with during HM

Language: Английский

Citations

18
Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy DOI
Huating Wang, Fan Yang,

J.D. Ye

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156245 - 156245

Published: Nov. 9, 2024

Language: Английский

Citations

10
Interactions between ABC gene polymorphisms and processing speed in predicting depression severity DOI Creative Commons

Meijiang Jin,

Lei Ji,

Maojia Ran

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 5, 2025

Language: Английский

Citations

0
Niuhuang Jiedu prescription alleviates realgar-induced dopaminergic and GABAergic neurotoxicity in Caenorhabditis elegans DOI
Ying Wang, Lin‐Juan Du,

Lingyue Zou

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119721 - 119721

Published: April 1, 2025

Language: Английский

Citations

0
Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation DOI
Xiaoyu Chen, Yuqing Wang, Ziqi Liu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 297, P. 118224 - 118224

Published: April 23, 2025

Language: Английский

Citations

0
Can Quercetin protect against the pre-disposing factors for Alzheimer’s disease via inhibiting NLRP3 inflammasome pathway? DOI
Azza S. Awad, Bassant M El-Mokadem,

Miar M. Sherif

et al.

Journal of Pharmacy and Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract Objectives The brain and its cognitive functions are most liable to stress, where it is known promote the pathological manifestation of Alzheimer’s disease (AD). This study aimed investigate effect a 2-week-period restraint stress (RS), as well protective Quercetin in dose-dependent manner against early start AD via studying NLRP3 inflammasome pathway. Methods rats were divided into four groups: control (Con), induction (Ind), 6 h/day for 2 weeks RS was induced, low high doses Q (Q1+Ind Q2+Ind, respectively), which administered before same period. Behavioral tests performed assess functions. Key findings higher dose has shown more inhibition pathway, oxidative phosphorylated-tau amyloid-β (Aβ) protein, significantly fired up by RS. These results backed with improved cellular structure histopathological examination enhanced functions, two have their effect. Conclusions proves that shielded initial pathogenesis AD, induced

Language: Английский

Citations

0
Manganese dioxide nanoparticles provoke inflammatory damage in BV2 microglial cells via increasing reactive oxygen species to activate the p38 MAPK pathway DOI

Xingchang Sun,

Xin Qin, Gaofeng Liang

et al.

Toxicology and Industrial Health, Journal Year: 2024, Volume and Issue: 40(5), P. 244 - 253

Published: March 22, 2024

With the widespread use of manganese dioxide nanoparticles (nano MnO 2 ), health hazards have also emerged. The inflammatory damage brain tissues could result from nano , in which underlying mechanism is still unclear. During this study, we aimed to investigate role ROS-mediated p38 MAPK pathway -induced response BV2 microglial cells. injury model was established by treating cells with 2.5, 5.0, and 10.0 μg/mL suspensions for 12 h. Then, reactive oxygen species (ROS) scavenger (20 nM N-acetylcysteine, NAC) inhibitor (10 μM SB203580) were used clarify ROS lesions results indicated that enhanced expression pro-inflammatory cytokines IL-1β TNF-α, elevated intracellular levels activated Controlling NAC inhibited activation attenuated induced . Furthermore, inhibition SB203580 led a decrease production factors (IL-1β TNF-α) In summary, can induce increasing further activating

Language: Английский

Citations

3
Potential Common Mechanisms of Cytotoxicity Induced by Organophosphorus Pesticides via NLRP3 Inflammasome Activation DOI Creative Commons
Xiao‐Ning Wang, Xin Sui, Yangyang Sun

et al.

GeoHealth, Journal Year: 2024, Volume and Issue: 8(4)

Published: April 1, 2024

Abstract The Multi‐Threat Medical Countermeasure (MTMC) technique is crucial for developing common biochemical signaling pathways, molecular mediators, and cellular processes. This study revealed that the Nod‐like receptor 3 (NLRP3) inflammasome pathway may be a significant contributor to cytotoxicity induced by various organophosphorus pesticides (OPPs). demonstrated exposure six different types of OPPs (paraoxon, dichlorvos, fenthion, dipterex, dibrom, dimethoate) led in BV2 cells, which was accompanied increased expression NLRP3 complexes (NLRP3, ASC, Caspase‐1) downstream inflammatory cytokines (IL‐1β, IL‐18), order dichlorvos > dipterex dibrom paraoxon fenthion dimethoate, based on IC 50 values 274, 410, 551, 585, 2,158, 1,527,566 μM, respectively. findings suggest targeting could potential approach broad‐spectrum antitoxic drugs combat multi‐OPPs‐induced toxicity. Moreover, inhibition efficiently protected cells against these OPPs, NLRP3, Caspase‐1, IL‐1β, IL‐18 decreased accordingly. affinity dimethoate (fenthion dipterex) K D 89.8, 325, 1,460, 2,690 Furthermore, mechanism NLRP3‐OPPs clarified presence toxicity effector groups (benzene ring, nitrogen/oxygen‐containing functional group); =O, ‐O‐, or =S (active) groups; combination residues (Gly271, Asp272). finding provided valuable insights into exploring mechanisms multiple threats effective therapeutic strategies prevent poisoning.

Language: Английский

Citations

3
(+)-catechin protects PC12 cells against CORT-induced oxidative stress and pyroptosis through the pathways of PI3K/AKT and Nrf2/HO-1/NF-κB DOI Creative Commons

Lai Chencen,

Shuo Zhang, Zhiyu Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 28, 2024

Pyroptosis induced by oxidative stress is a significant contributor to mental health disorders, including depression (+)-Catechin (CA), polyphenolic compound prevalent in various food sources, has been substantiated prior research exhibit potent antioxidant properties and potential antidepressant effects. Nonetheless, the precise antidepressive mechanisms effects of CA remain incompletely elucidated. In this study, we employed corticosterone (CORT) PC12 cells develop cellular model depression, aiming investigate protective against CORT-induced damage. Our objective was elucidate underlying action. We utilized transcriptomic analysis identify differentially expressed genes bioinformatics approaches predict CA’s cells. These predictions were subsequently validated through western blot analysis. The findings indicated that possesses capacity mitigate suppress pyroptosis via activation PI3K/AKT signaling pathway. This modulates Nrf2/HO1/NF-κB pathways, thereby providing protection damage CORT. Furthermore, investigated interaction between Keap1 protein employing molecular docking thermal shift assays. propose can activate Nrf2 two decrease reactive oxygen species (ROS) levels inhibit pyroptosis: one mechanism involves pathway, other direct binding Keap1, leading an increase p-Nrf2.

Language: Английский

Citations

3
Betaine improves METH-induced depressive-like behavior and cognitive impairment by alleviating neuroinflammation via NLRP3 inflammasome inhibotion DOI

Rongji Hui,

Jiabao Xu,

Maijie Zhou

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 135, P. 111093 - 111093

Published: July 17, 2024

Language: Английский

Citations

2