Chemosphere, Journal Year: 2024, Volume and Issue: unknown, P. 143605 - 143605
Published: Oct. 1, 2024
Language: Английский
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11
Published: March 22, 2023
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent disorder. With improvement in human living standards, prevalence of NAFLD has been increasing recent years. Endocrine-disrupting chemicals (EDCs) are a class exogenous that simulate effects hormones body. There growing evidence regarding potential EDCs on health, especially NAFLD. This paper aims to summarize major contribute burden and raise public awareness hazards posed by with objective reducing incidence
Language: Английский
Citations
16
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0301097 - e0301097
Published: April 19, 2024
As a new definition for the evidence of hepatic steatosis and metabolic dysfunctions, relationship between phthalates (PAEs) dysfunction-associated fatty liver disease (MAFLD) remains virtually unexplored. This study included 3,137 adults from National Health Nutrition Examination Survey spanning 2007-2018. The diagnosis MAFLD depended on US Fatty Liver Index (US FLI) dysregulation. Eleven metabolites PAEs were in study. Poisson regression, restricted cubic spline (RCS), weighted quantile sum (WQS) regression used to assess associations phthalate MAFLD. After adjusting potential confounders, analysis showed that mono-2-ethyl-5-carboxypentyl (MECPP), mono-n-butyl phthalate, mono-(3-carboxypropyl) mono-ethyl (MEP), mono-(2-ethyl-5-hydroxyhexyl) (MEHHP) mono-(2-ethyl-5-oxohexyl) generally significant positively associated with (P<0.05). Furthermore, WQS index constructed eleven was significantly related (OR:1.43; 95%CI: 1.20, 1.70), MEHHP (33.30%), MEP (20.84%), MECPP (15.43%), mono-isobutyl (11.78%) contributing most. suggests exposure phthalates, individually or combination, may be an increased risk
Language: Английский
Citations
6
Pharmacological Research, Journal Year: 2024, Volume and Issue: 205, P. 107251 - 107251
Published: June 12, 2024
Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes chronic worldwide. Epidemiological studies have reported that exposure population to environmental endocrine-disrupting chemicals (EDCs) associated with NAFLD. However, EDCs are different types, and there inconsistencies in relevant evidence descriptions, which not been systematically summarized so far. Therefore, this study aimed determine association between Three databases, including PubMed, Web science, Embase were searched, 27 articles included study. Methodological quality, heterogeneity, publication bias assessed using Newcastle-Ottawa scale, I
Language: Английский
Citations
6
Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(52), P. 78555 - 78587
Published: June 13, 2022
Language: Английский
Citations
22
Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9
Published: Nov. 22, 2022
Although phthalates are common environmental pollutants, few studies have focused on the relationship of exposure with non-alcoholic fatty liver disease (NAFLD) or fibrosis, and especially, alternative been questioned in recent years about whether they better choices. Thus, this study aimed to explore associations major NAFLD fibrosis.Data 1450 adults from National Health Nutrition Examination Survey (NHANES) 2017-2018 were collected. The urinary metabolite concentrations di-2-ethylhexyl phthalate (DEHP), diisononyl (DINP) diisodecyl (DIDP) detected. Controlled attenuation parameter (CAP) median stiffness measurement (LSM) acquired for quantitative diagnosis fibrosis by vibration-controlled transient elastography. Multivariate logistic regression analysis linear performed examine between fibrosis.After adjustment potential factors, prevalence was significantly elevated among those fourth quartile mono-(2-ethyl-5-carboxypentyl) (OR, 95%CI = 2.719, 1.296, 5.700, P 0.016), mono (2-ethyl-5-hydroxyhexyl) 2.073, 1.111, 3.867, 0.037). No significant association found NAFLD. similar result gained that MECPP still associated Ln CAP (Q4 vs. Q1: β, 0.067, 0.017, 0.118, 0.027). After same covariates, no logistics analysis.All all, higher is correlated DEHP but not DINP DIDP American adults. There defined as LSM ≥ 8 Kpa. Nevertheless, further research needed provide evidence causality.
Language: Английский
Citations
21
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 254, P. 114720 - 114720
Published: March 6, 2023
Whether exposure to organophosphate esters (OPEs) is associated with metabolic dysfunction-associated fatty liver disease (MAFLD) and nonalcoholic (NAFLD) remains unclear. A healthy diet crucial health dietary intake also an important route for OPEs exposure. However, the joint associations of OPEs, quality, effect modification by quality remain unknown. This study comprised 2618 adults complete data on 6 urinary metabolites, 24 h recalls, definitions NAFLD MAFLD from 2011-2018 National Health Nutrition Examination Survey cycles. Multivariable binary logistic regression was applied assess metabolites NAFLD, MAFLD, components MAFLD. We adopted quantile g-Computation method examine mixture. Our results revealed that mixture three individual [i.e., bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis(2-chloroethyl) phosphate, diphenyl phosphate] were significantly positively (P-trend<0.001), BDCIPP being identified as dominant metabolite, whereas 4 scores monotonically inversely both (P-trend<0.001). Of note, large negatively BDCIPP, but not other metabolites. Joint association analyses individuals higher lower concentration tend have odds having in comparison people low high group, modified quality. findings suggest certain exhibited opposing NAFLD. Individuals adherent a healthier may level thus could
Language: Английский
Citations
11
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: Sept. 25, 2024
Non-alcoholic fatty liver disease (NAFLD) is the most common disease. Phthalates have been suggested to influence development of NAFLD due their endocrine-disrupting properties, but studies based on nationally representative populations are insufficient, and existing seem reached conflicting conclusions. Due changes in legislation, use traditional phthalates has gradually decreased, substitutes getting more attention. This study aims delve deeper into how choice diagnostic approach influences observed correlations concern about alternatives phthalates, thereby offering precise references for prevention treatment NAFLD. A cohort 641 participants, sourced from National Health Nutrition Examination Survey (NHANES) 2017-2018 database, was evaluated using three methods: Hepatic Steatosis Index (HSI), US Fatty Liver Indicator (US.FLI), Vibration Controlled Transient Elastography (VCTE). The urinary metabolite concentrations Di-2-ethylhexyl phthalate (DEHP), Di-isodecyl (DIDP), Di-isononyl (DINP), Di-n-butyl (DnBP), Di-isobutyl (DIBP), Di-ethyl (DEP) Di-n-octyl (DnOP) were detected. association between metabolites through univariate multivariate logistic regression analyses, considering different concentration gradients phthalates. Univariate analysis found significant specific metabolites, such as Mono-(2-ethyl-5-oxohexyl) (MEOHP), Mono-(2-ethyl-5-hydroxyhexyl) (MEHHP), Mono-2-ethyl-5-carboxypentyl (MECPP), Mono-(carboxyisoctyl) (MCiOP), across criteria. In a adjusting only demographic data, MEOHP (OR = 3.26, 95% CI 1.19-8.94, p 0.029), MEHHP 3.98, 1.43-11.1, 0.016), MECPP 3.52, 1.01-12.2, 0.049), MCiOP 4.55, 1.93-10.7, 0.005) positively related defined by HSI VCTE. correlation strength varied with indicating potential dose-response relationship. Adjusting all covariates regression, 4.22, 1.10-16.2, 0.044), an oxidative DINP, remained significantly associated under VCTE criterion, suggesting its role risk factor research highlights DINP These findings underscore need further investigation pathogenesis importance criteria research.
Language: Английский
Citations
4
Metabolites, Journal Year: 2022, Volume and Issue: 12(2), P. 167 - 167
Published: Feb. 10, 2022
Exposomics analyses have highlighted the importance of biomonitoring human exposure to pollutants, even non-persistent, for prevention non-communicable diseases such as obesity, diabetes, non-alcoholic fatty liver disease, atherosclerosis, and cardiovascular diseases. Phthalates bisphenol A (BPA) are endocrine disrupting chemicals (EDCs) widely used in industry a large range daily life products that increase risk cardiometabolic especially if starts during childhood. Thus, these compounds is important not only adulthood but also This was goal LIFE-PERSUADED project measured phthalates (DEHP metabolites, MEHP, MEHHP, MEOHP) BPA Italian mother-children couples different ages. In this paper we describe method set up LIFE PERSUADED validated proficiency test (ICI/EQUAS) showing accurate determination urinary can be achieved starting from small sample size (0.5 mL) using two MS techniques applied cascade on same deconjugated matrix.
Language: Английский
Citations
18
Experimental Gerontology, Journal Year: 2023, Volume and Issue: 182, P. 112296 - 112296
Published: Oct. 1, 2023
Energy-adjusted dietary inflammatory index (E-DII) can represent daily components and chronic response is an important pathogenesis of aging, nonalcoholic fatty liver disease (NAFLD) frailty. Therefore, the purpose this study to explore association E-DII frailty in older adults with NAFLD.This cross-sectional utilized data from National Health Nutrition Examination Survey (2005-2016) investigate between The NAFLD status was determined using US Fatty Liver Index (FLI) value ≥30. relationship examined through multivariate weighted logistic regression analysis smooth curve fitting. Subgroup analyses were conducted, considering various demographic clinical variables.Our final included 1586 individuals, average age 69.42 years, 53.15 % them males. overall prevalence population 39.42 %. Smooth fitting demonstrated a nearly linear H. pylori. Utilizing analysis, we found that odds ratio (OR) for 1.08 (95%CI, 1.03-1.15). further confirmed independently increased risk frailty.Higher levels be associated NAFLD. However, studies are required fully elucidate precise mechanisms underlying
Language: Английский
Citations
10
Journal of Global Health, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 16, 2025
Prehypertension and hypertension often coexist with non-alcoholic fatty liver disease (NAFLD) during the progression of cardiovascular (CVD). International academic societies have recently reached a consensus to replace NAFLD new term 'steatotic disease' (SLD). In this study, we aimed evaluate impact different SLD subtypes on all-cause CVD mortality in individuals prehypertension or hypertension. We included 6074 adults from National Health Nutrition Examination Survey (2003-18). The US index was used as diagnostic criterion for SLD, participants were classified into no metabolic dysfunction-associated steatotic (MASLD), alcohol-related (MetALD), (ALD). For cases MASLD, MetALD, ALD, further assessed advanced fibrosis using fibrosis-4 (FIB-4) index. Additionally, calculated hazard ratios (HRs) 95% confidence intervals (CIs) Cox proportional hazards regression models assess associations mortality. There 3505 (57.7%) 1284 (21.1%) 777 (12.8%) 508 (8.4%) ALD. During median follow-up period 8.2 years, risk progressively increased MASLD (HR = 1.28; CI 1.01-1.63 HR 1.55; 1.04-2.33, respectively), MetALD 1.41; 1.05-1.88 1.78; 1.10-2.87, ALD 1.83; 1.32-2.53 1.80; 1.01-3.19, respectively). Among also associated an Individuals had higher than those without SLD. Therefore, early intervention strategies targeting prevention management may help improve their long-term health.
Language: Английский
Citations
0