Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 132, P. 108470 - 108470

Published: Dec. 5, 2022

Language: Английский

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Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-κB signal in mice

Environmental Pollution, Journal Year: 2023, Volume and Issue: 320, P. 121068 - 121068

Published: Jan. 11, 2023

Language: Английский

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Polystyrene microplastics induced inflammation with activating the TLR2 signal by excessive accumulation of ROS in hepatopancreas of carp (Cyprinus carpio)

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 251, P. 114539 - 114539

Published: Jan. 12, 2023

Polystyrene microplastics (PS-MPs) affect the immune defense function on carp (Cyprinus carpio). The PS-MPs model of was established by feeding with particle size 8 µm and concentration 1000 ng/L water. Hepatopancreas test revealed activities AKP, ALT, AST LDH abnormal increase. induced tissue damage lead to hepatopancreas function. also a oxidative stress antioxidant enzymes SOD, CAT, GSH-PX, T-AOC decreasing reactive oxygen species (ROS) excessive accumulation. activated Toll like receptor-2 (TLR2) signaling pathway. mRNA protein expressions TLR2, Myeloid differentiation primary response 88 (MyD88), tumor necrosis factor receptor-associated 6 (TRAF6), NF-κB p65, Tumor (TNF-α), Interleukin-1β (IL-1β), Inducible Nitric Oxide Synthase (iNOS), cycooxygenase 2(COX2) increased in both hepatocytes qPCR Western blotting analysis mode. ELISA showed TNF-α, IL-1β, iNOS, COX2 inflammatory molecule were hepatocytes. results that caused serious injure brought effects carp. present study displayed harm freshwater fish, provided some suggestions references for toxicological studies environment.

Language: Английский

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Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4 / MyD88 / NF-κB pathway

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 140, P. 108995 - 108995

Published: Aug. 11, 2023

Language: Английский

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Micro-algal astaxanthin improves lambda-cyhalothrin-induced necroptosis and inflammatory responses via the ROS-mediated NF-κB signaling in lymphocytes of carp (Cyprinus carpio L.)

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 139, P. 108929 - 108929

Published: July 4, 2023

Language: Английский

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Polystyrene microplastics induce myocardial inflammation and cell death via the TLR4/NF-κB pathway in carp

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 135, P. 108690 - 108690

Published: March 21, 2023

Language: Английский

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TBBPA induced ROS overproduction promotes apoptosis and inflammation by inhibiting autophagy in mice lung

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 252, P. 114607 - 114607

Published: Feb. 2, 2023

Tetrabromobisphenol A (TBBPA), a non-degradable environmental pollutant, was discharge into the air during manufacture, use and recycling of plastic products. Respiratory exposure is main way to inhalation TBBPA. However, research on damage TBBPA respiratory system still extremely few. The aim this experiment explore mechanism toxicity lungs. Forty C57BL/6 J mice randomly divided 4 groups, experimental groups with at 10 n M/kg, 20 M/kg 40 for 14 consecutive days. Histopathological ultrastructural analysis showed that inflammatory cells infiltrated tissue structure damaged in lung exposing ROS MDA levels increase T-AOC, GSH-Px, CAT, SOD activities inhibition found exposure. expression autophagy-related factors Beclin-1, P62, LC3-II, ATG5, ATG7 decreased. activation NF-κB/TNF-α pathway indicates occurrence inflammation. Bax, caspase3, caspase7, caspase 9 increase, Bcl-2 decreased, apoptosis activated. autophagy inducer rapamycin can reverse adverse effects inflammation apoptosis. Taken together, inhibits autophagy-induced pneumonia by overproduction ROS.

Language: Английский

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Selenium deficiency induced inflammation and apoptosis via NF-κB and MAPKs pathways in muscle of common carp (Cyprinus carpio L.)

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 138, P. 108847 - 108847

Published: May 23, 2023

Language: Английский

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TBBPA causes inflammation and cell death via the ROS/NF-κB pathway in the gastric mucosa

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 262, P. 115320 - 115320

Published: July 31, 2023

Tetrabromobisphenol A (TBBPA) is a common brominated flame retardant that has wide range of toxic effects on organisms. However, the mechanism TBBPA digestive system rarely been studied. The purpose this study was to investigate toxicity gastric mucosa. In study, (mixed with corn oil) administered by gavage at doses 0 mg/kg (CG), 10 and 20 mg/kg. results showed levels ROS, MDA LPO were increased, activities antioxidant enzymes decreased. Large amounts ROS activated NF-κB pathway, leading development an inflammatory response. expression BCL family Caspase (Cas) genes inducing apoptosis. RIP3/MLKL pathway activated, cell necrosis. summary, can cause damage mucosa through oxidative stress, increased activation pathway. Treatment NAC alleviated caused TBBPA.

Language: Английский

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Polyethylene microplastics cause apoptosis via the MiR-132/CAPN axis and inflammation in carp ovarian

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 265, P. 106780 - 106780

Published: Nov. 28, 2023

Language: Английский

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