Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: June 26, 2023

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially fish. Fish is a staple affordable food source, rich animal protein, along with various vitamins, essential amino acids, minerals. Exposure of fish to microplastics, pesticides, nanoparticles generates ROS induces oxidative stress, inflammation, immunotoxicity, genotoxicity, DNA damage alters gut microbiota, thus reducing growth quality Changes behavioral patterns, swimming, feeding habits were also observed under exposures above contaminants. These affect Nrf-2, JNK, ERK, NF-κB, MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes Effects found modulate antioxidant enzymes, including superoxide dismutase, catalase, glutathione system. So, protect health from contribution nano-technology or nano-formulations was researched. A decrease nutritional population significantly impacts human diet, influencing traditions economics worldwide. On other hand, traces microplastics habitat water can enter humans by consuming contaminated may result serious hazards. This review summarizes stress caused due nano-particle contamination exposure their impact health. As rescue mechanism, use management disease discussed.

Language: Английский

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Polystyrene microplastics induce endoplasmic reticulum stress, apoptosis and inflammation by disrupting the gut microbiota in carp intestines

Environmental Pollution, Journal Year: 2023, Volume and Issue: 323, P. 121233 - 121233

Published: Feb. 14, 2023

Language: Английский

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Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 262, P. 106659 - 106659

Published: Aug. 14, 2023

Language: Английский

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Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4 / MyD88 / NF-κB pathway

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 140, P. 108995 - 108995

Published: Aug. 11, 2023

Language: Английский

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Microplastics and Oxidative Stress—Current Problems and Prospects

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 579 - 579

Published: May 8, 2024

Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community general public, as they threaten environment. contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, apoptosis. They affect cells, tissues, organs, overall health, potentially contributing conditions like cancer cardiovascular disease. pose a significant danger due their widespread occurrence food. In recent years, information has emerged indicating MPs can cause oxidative stress (OS), known factor accelerating aging organisms. This comprehensive evaluation exposed notable variability reported connection OS. work aims provide critical review whether harmfulness constitute environmental contaminants may result OS through analysis research existing literature, well an assessment characteristics causing Additionally, article covers analytical methodology used this field. The conclusions point necessity for further into effects on

Language: Английский

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Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis

Marine Environmental Research, Journal Year: 2024, Volume and Issue: 196, P. 106423 - 106423

Published: Feb. 27, 2024

Language: Английский

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Toll-like receptor signaling in teleosts

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

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Immune response to polystyrene microplastics: Regulation of inflammatory response via the ROS-driven NF-κB pathway in zebrafish (Danio rerio)

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 282, P. 107308 - 107308

Published: March 3, 2025

Language: Английский

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Polystyrene microplastics induce myocardial inflammation and cell death via the TLR4/NF-κB pathway in carp

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 135, P. 108690 - 108690

Published: March 21, 2023

Language: Английский

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TBBPA induced ROS overproduction promotes apoptosis and inflammation by inhibiting autophagy in mice lung

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 252, P. 114607 - 114607

Published: Feb. 2, 2023

Tetrabromobisphenol A (TBBPA), a non-degradable environmental pollutant, was discharge into the air during manufacture, use and recycling of plastic products. Respiratory exposure is main way to inhalation TBBPA. However, research on damage TBBPA respiratory system still extremely few. The aim this experiment explore mechanism toxicity lungs. Forty C57BL/6 J mice randomly divided 4 groups, experimental groups with at 10 n M/kg, 20 M/kg 40 for 14 consecutive days. Histopathological ultrastructural analysis showed that inflammatory cells infiltrated tissue structure damaged in lung exposing ROS MDA levels increase T-AOC, GSH-Px, CAT, SOD activities inhibition found exposure. expression autophagy-related factors Beclin-1, P62, LC3-II, ATG5, ATG7 decreased. activation NF-κB/TNF-α pathway indicates occurrence inflammation. Bax, caspase3, caspase7, caspase 9 increase, Bcl-2 decreased, apoptosis activated. autophagy inducer rapamycin can reverse adverse effects inflammation apoptosis. Taken together, inhibits autophagy-induced pneumonia by overproduction ROS.

Language: Английский

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