Selenium yeast improve growth, serum biochemical indices, metabolic ability, antioxidant capacity and immunity in black carp Mylopharyngodn piceus DOI
Penghui Zhang, Chen Zhang,

Xinfeng Yao

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 146, P. 109414 - 109414

Published: Feb. 1, 2024

Language: Английский

Selenium deficiency induced inflammation and apoptosis via NF-κB and MAPKs pathways in muscle of common carp (Cyprinus carpio L.) DOI
Ran Xu,

Jing-wen Cao,

Tianchao Xu

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 138, P. 108847 - 108847

Published: May 23, 2023

Language: Английский

Citations

25
Zinc deficiency causes oxidative stress, endoplasmic reticulum stress, apoptosis and inflammation in hepatocytes in grass carp DOI
Jie Cui, Tianchao Xu, Hongli Lv

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 139, P. 108905 - 108905

Published: June 21, 2023

Language: Английский

Citations

25
TBBPA causes inflammation and cell death via the ROS/NF-κB pathway in the gastric mucosa DOI Creative Commons
Shuang Xu, Xiaoran Sun, Jiawei Wu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 262, P. 115320 - 115320

Published: July 31, 2023

Tetrabromobisphenol A (TBBPA) is a common brominated flame retardant that has wide range of toxic effects on organisms. However, the mechanism TBBPA digestive system rarely been studied. The purpose this study was to investigate toxicity gastric mucosa. In study, (mixed with corn oil) administered by gavage at doses 0 mg/kg (CG), 10 and 20 mg/kg. results showed levels ROS, MDA LPO were increased, activities antioxidant enzymes decreased. Large amounts ROS activated NF-κB pathway, leading development an inflammatory response. expression BCL family Caspase (Cas) genes inducing apoptosis. RIP3/MLKL pathway activated, cell necrosis. summary, can cause damage mucosa through oxidative stress, increased activation pathway. Treatment NAC alleviated caused TBBPA.

Language: Английский

Citations

25
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota DOI Creative Commons
Kan Li, Jiawei Wu, Shuang Xu

et al.

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(5)

Published: Aug. 18, 2023

The host-bacterial interactions play the key role in inflammatory bowel disease (IBD). Dysbiosis of intestinal flora can lead to pathological changes intestine. Rosmarinic acid (RA) is a natural phenolic compound with antioxidant, anti-cancer, anti-inflammatory, anti-apoptotic, anti-fibrotic, and anti-bacterial activities that has palliative effect on acute IBD. We have established an vivo model for mice. Histological staining was performed directly observe RA alterations tract. alteration mouse observed by 16S rRNA high-throughput sequencing, mechanism action detected qPCR western blot. results showed had significant protective upregulated abundance Lactobacillus johnsonii Candidatus Arthromitus sp SFB-mouse-NL downregulated Bifidobacterium pseudolongum, Escherichia coli, Romboutsia ilealis. expressions ROCK, RhoA, CaM, MLC, MLCK, ZEB1, ZO-1, ZO-2, occludin, E-cadherin, IL-1β, IL-6, TNF-α, GRP78, PERK, IRE1, ATF6, CHOP, Caspase12, Caspase9, Caspase3, Bax, Cytc, RIPK1, RIPK3, MLKL, expression IL-10 Bcl-2. These displayed inhibited inflammation, which caused tight junction damage, repairing dysbiosis, relieved endoplasmic reticulum stress, cell death, corrected smooth muscle contractile dysregulation. this study revealed could small intestine mice regulating flora. IMPORTANCE Inflammatory (IBD) chronic, relapsing, remitting disorder gastrointestinal system. In study, we investigated effects rosmarinic effective reducing contraction abnormalities, disorders.

Language: Английский

Citations

23
Probabilistic risk assessment of microplastics in Tai Lake, China DOI

Seerat Ul Ain Bhutto,

Muhammad Akram,

Xue‐yi You

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 914, P. 169965 - 169965

Published: Jan. 10, 2024

Language: Английский

Citations

10
Immunotoxicity of microplastics in fish DOI
Huiqi Li,

Huanpeng Liu,

Liuliu Bi

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 150, P. 109619 - 109619

Published: May 10, 2024

Language: Английский

Citations

10
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis via the ROS/NF-κB pathway in a mouse model DOI
Xiaoran Sun, Shuang Xu, Tianjing Liu

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(13), P. 7136 - 7147

Published: Jan. 1, 2024

Zinc (Zn) is an important trace element; it involved in the regulation and maintenance of many physiological functions organisms has anti-inflammatory antioxidant properties.

Language: Английский

Citations

7
Combined neurotoxicity of aged microplastics and thiamethoxam in the early developmental stages of zebrafish (Danio rerio) DOI
Yanan Sun, Ping Ding, Jiayi Zhang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123853 - 123853

Published: March 27, 2024

Language: Английский

Citations

6
Polyethylene microplastics cause apoptosis via the MiR-132/CAPN axis and inflammation in carp ovarian DOI

Mengran Zhu,

Hongru Wang,

Fu-xin Han

et al.

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 265, P. 106780 - 106780

Published: Nov. 28, 2023

Language: Английский

Citations

14
Chronic exposure to low concentrations of microplastics causing gut tissue damage but non-significant changes in the microbiota of marine medaka larvae (Oryzias melastigma) DOI
Shaobai Wen, Xiuran Yin,

Yankun Zhang

et al.

Marine Environmental Research, Journal Year: 2024, Volume and Issue: 195, P. 106381 - 106381

Published: Jan. 26, 2024

Language: Английский

Citations

5