Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 262, P. 106659 - 106659

Published: Aug. 14, 2023

Language: Английский

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Tea polyphenols alleviate TBBPA-induced inflammation, ferroptosis and apoptosis via TLR4/NF-κB pathway in carp gills

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 146, P. 109382 - 109382

Published: Jan. 18, 2024

Language: Английский

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TBBPA causes inflammation and cell death via the ROS/NF-κB pathway in the gastric mucosa

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 262, P. 115320 - 115320

Published: July 31, 2023

Tetrabromobisphenol A (TBBPA) is a common brominated flame retardant that has wide range of toxic effects on organisms. However, the mechanism TBBPA digestive system rarely been studied. The purpose this study was to investigate toxicity gastric mucosa. In study, (mixed with corn oil) administered by gavage at doses 0 mg/kg (CG), 10 and 20 mg/kg. results showed levels ROS, MDA LPO were increased, activities antioxidant enzymes decreased. Large amounts ROS activated NF-κB pathway, leading development an inflammatory response. expression BCL family Caspase (Cas) genes inducing apoptosis. RIP3/MLKL pathway activated, cell necrosis. summary, can cause damage mucosa through oxidative stress, increased activation pathway. Treatment NAC alleviated caused TBBPA.

Language: Английский

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Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(5)

Published: Aug. 18, 2023

The host-bacterial interactions play the key role in inflammatory bowel disease (IBD). Dysbiosis of intestinal flora can lead to pathological changes intestine. Rosmarinic acid (RA) is a natural phenolic compound with antioxidant, anti-cancer, anti-inflammatory, anti-apoptotic, anti-fibrotic, and anti-bacterial activities that has palliative effect on acute IBD. We have established an vivo model for mice. Histological staining was performed directly observe RA alterations tract. alteration mouse observed by 16S rRNA high-throughput sequencing, mechanism action detected qPCR western blot. results showed had significant protective upregulated abundance Lactobacillus johnsonii Candidatus Arthromitus sp SFB-mouse-NL downregulated Bifidobacterium pseudolongum, Escherichia coli, Romboutsia ilealis. expressions ROCK, RhoA, CaM, MLC, MLCK, ZEB1, ZO-1, ZO-2, occludin, E-cadherin, IL-1β, IL-6, TNF-α, GRP78, PERK, IRE1, ATF6, CHOP, Caspase12, Caspase9, Caspase3, Bax, Cytc, RIPK1, RIPK3, MLKL, expression IL-10 Bcl-2. These displayed inhibited inflammation, which caused tight junction damage, repairing dysbiosis, relieved endoplasmic reticulum stress, cell death, corrected smooth muscle contractile dysregulation. this study revealed could small intestine mice regulating flora. IMPORTANCE Inflammatory (IBD) chronic, relapsing, remitting disorder gastrointestinal system. In study, we investigated effects rosmarinic effective reducing contraction abnormalities, disorders.

Language: Английский

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Assessing microbiological and heavy metal pollution in surface waters associated with potential human health risk assessment at fish ingestion exposure

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135187 - 135187

Published: July 11, 2024

Language: Английский

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Polyethylene microplastics induced inflammation via the miR-21/IRAK4/NF-κB axis resulting to endoplasmic reticulum stress and apoptosis in muscle of carp

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 145, P. 109375 - 109375

Published: Jan. 11, 2024

Language: Английский

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Nano‑selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 915, P. 170129 - 170129

Published: Jan. 17, 2024

Language: Английский

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Microplastics induced endoplasmic reticulum stress to format an inflammation and cell death in hepatocytes of carp (Cyprinus carpio)

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 269, P. 106870 - 106870

Published: Feb. 19, 2024

Language: Английский

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High-fat diet disrupts the gut microbiome, leading to inflammation, damage to tight junctions, and apoptosis and necrosis in Nyctereutes procyonoides intestines

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(4)

Published: Feb. 20, 2024

ABSTRACT Given the burgeoning Nyctereutes procyonoides breeding industry and its growing scale, it is imperative to investigate impact of high-fat diets on health these animals. This study involved 30 male comparable weights (3 kg ±0.5), randomly assigned either a control group or diet ( n = 15 each). The latter was fed mixture lard basal in 2:5 ratio, establishing model procyonoides. induced diarrhea histopathological changes Analysis small intestine contents using 16S rRNA sequencing revealed diet-induced disruption gut microbiota. Specifically, Escherichia-Shigella emerged as biomarker P 0.049), while Vagococcus prevalent indicating significant increase harmful bacteria group. Furthermore, this disrupted flora correlated with inflammation oxidative stress, evidenced by marked increases TNF-α < 0.01), IL-1β 0.05), IL-6 0.05) levels, measured via q-PCR, Western blot, stress assays. In addition, q-PCR analysis upregulation apoptosis necrosis markers, including Bax, Caspase3, Caspase9, Caspase12, RIPK3, RIPK1 0.01 0.001), concurrent downregulation anti-apoptotic gene Bcl-2 0.01) group, consistent protein expression trends. These findings suggest that alters microbiome toward more bacterial composition, escalating inflammatory responses intestinal tissue permeability, culminating cell necrosis. IMPORTANCE examines Our research established diet, revealing impacts, such diarrhea, histological anomalies, alterations emphasize importance preventing issues promoting sustainable growth. They highlight microbiota overall animal health.

Language: Английский

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Polyethylene microplastics cause apoptosis via the MiR-132/CAPN axis and inflammation in carp ovarian

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 265, P. 106780 - 106780

Published: Nov. 28, 2023

Language: Английский

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