Arsenic-induced prostate cancer: an enigma

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 6, 2024

Language: Английский

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Exposure to potentially toxic elements (PTEs) and the risk of male infertility- A Systematic review and meta-analysis

Journal of Gynecology Obstetrics and Human Reproduction, Journal Year: 2024, Volume and Issue: 53(6), P. 102782 - 102782

Published: March 28, 2024

Language: Английский

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The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(9)

Published: July 22, 2023

Language: Английский

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Protective effects of macromolecular polyphenols, metals (zinc, selenium, and copper) - Polyphenol complexes, and different organs with an emphasis on arsenic poisoning: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126715 - 126715

Published: Sept. 5, 2023

Language: Английский

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Silymarin: A Natural Compound for Obesity Management

Obesities, Journal Year: 2024, Volume and Issue: 4(3), P. 292 - 313

Published: Aug. 9, 2024

Silybum marianum (L.) Gaertn, commonly known as milk thistle, is an herbal medicine rich in silymarin, a bioflavonoid complex. Historically, silymarin was used for treating liver diseases, but recent studies highlight silymarin’s potential obesity management. This narrative review aims to provide in-depth examination of the existing knowledge and its secondary compounds concerning associated comorbidities, summarizing data from vitro, preclinical, clinical studies. Obesity significant public health issue, exacerbated during COVID-19 pandemic, major risk factor mortality. It contributes metabolic dysfunction, including oxidative stress, metainflammation, cardiovascular type 2 diabetes development. Silymarin has demonstrated benefits on insulin signaling lipid metabolism, well antioxidant anti-inflammatory properties at molecular level. Innovative also suggest prebiotic, positively influencing gut microbiota composition, key affected by obesity. These promising findings support anti-obesity action practice. Looking forward, using innovative complementary therapy could offer substantial natural promotion Nevertheless, further research into optimal doses cellular mechanisms still needed.

Language: Английский

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Reduction Removal of Cr(VI) Using Oxalic Acid With MOF‐525(Fe) as Catalyst: Performance and Mechanism

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

ABSTRACT Hexavalent chromium (Cr(VI)) has attracted great considerations due to their high toxicity, teratogenicity, and carcinogenicity. In this study, four Zr‐MOFs were synthesized used comparative study catalytic performances of oxalic acid (OA) for Cr(VI) removal. Results showed that the removal efficiency was reached 65.91%, 78.64%, 53.58%, 96.32% by MOF‐525, MOF‐525(Co), MOF‐525(Zn), MOF‐525(Fe) in presence OA when initial concentration 100 mg·L −1 , respectively. The single‐factor experiments further improving MOF‐525(Fe)/OA demonstrated optimal conditions dosage 790 500 pH 2.0, system could be treat Cr(VI)‐containing wastewater at concentrations below 50 . Ionic strength studies indicated Na + K Mg 2+ Cl − SO 4 2− had little effect on reduction Cr(VI), while Ca (0.10 0.25 mol·L ), NO 3 (0.25 PO 3− ) significant inhibition effects. reusability stability excellent, it potential applications. Based results Fourier transform infrared spectroscopy (FTIR), X‐ray photoelectron (XPS), Electron Paramagnetic Resonance spectrometer (EPR), possible mechanism proposed as follows: complexation with Fe 3+ first complexed produce CO 2 •− then combined Zr–O Fe–O clusters obtain activation energy, ability enhanced same time; finally, obtained electrons from sequentially reduced Cr(V) Cr(III).

Language: Английский

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Environmental and Genetic Traffic in the Journey from Sperm to Offspring

Biomolecules, Journal Year: 2023, Volume and Issue: 13(12), P. 1759 - 1759

Published: Dec. 7, 2023

Recent advancements in the understanding of how sperm develop into offspring have shown complex interactions between environmental influences and genetic factors. The past decade, marked by a research surge, has not only highlighted profound impact paternal contributions on fertility reproductive outcomes but also revolutionized our comprehension unveiling parental factors sculpt traits successive generations through mechanisms that extend beyond traditional inheritance patterns. Studies are more susceptible to factors, especially during critical phases growth. While these broadly detrimental health, their effects acute periods. Moving immutable nature genome, epigenetic profile cells emerges as dynamic architecture. This flexibility renders it disruptions. primary objective this review is shed light diverse processes which agents affect male capacity. Additionally, explores consequences interactions, demonstrating can reverberate offspring. It encompasses direct changes well broad spectrum adaptations. By consolidating current empirically supported research, offers an exhaustive perspective interwoven trajectories environment, genetics, epigenetics elaborate transition from

Language: Английский

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Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

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Multigenerational effects of arsenate on development and reproduction in marine copepod Tigriopus japonicus

Chemosphere, Journal Year: 2023, Volume and Issue: 342, P. 140158 - 140158

Published: Sept. 12, 2023

Language: Английский

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Mitigating effect of gallic acid on zinc oxide nanoparticles and arsenic trioxide-induced spermatogenesis suppression, testicular injury, hormonal imbalance, and immunohistochemical changes in rats

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9859 - 9875

Published: June 27, 2024

Abstract The current study compared the effects of incorporated exposure to arsenic trioxide (As) and zinc oxide nanoparticles (ZnONPs) on male reproductive hormones, oxidative stress, inflammatory biomarkers in adult rats each metal alone. A defensive trial with gallic acid (GA) has also been studied. total 60 Sprague Dawley were categorized into six groups: control, GA (20 mg/kg), ZnONPs (100 As (8 As, concurrently at same previous doses. regimens applied for days sequence. Current findings showed significant weight loss all groups, testicular weights significantly decreased combined groups. Testosterone, follicular stimulating hormone, luteinizing hormone serum levels considerably reduced, while estradiol increased. Inducible nitric synthase (iNOS) immunoexpression was upregulated proliferating cell nuclear antigen (PCNA) downregulated. Moreover, there a elevation malondialdehyde, reduction superoxide dismutase, glutathione peroxidase disruptive testes, prostate glands, seminal vesicle alterations experimental groups marked changes group. Additionally, present results revealed protective adverse rats. enhanced sperm picture, oxidant status, hormonal profile. Also, it modulates iNOS PCNA recovers histoarchitecture vesicles. Ultimately, may be promising safeguarding agent against As-induced disturbances parameters .

Language: Английский

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