Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence DOI Creative Commons
Madjid Djouina,

Suzie Loison,

Mathilde Body–Malapel

et al.

Microplastics, Journal Year: 2024, Volume and Issue: 3(2), P. 217 - 233

Published: April 8, 2024

The tremendous plastic production and poor post-use management are current future sources of environmental human contamination due to their degradation products: microplastics nanoplastics (MNPLs). Methodological developments have allowed MNPLs be detected in an increasing variety foods, as well stool colonic mucosa. It was suggested early that the direct contact between intestinal tissues could represent a potential risk for health. In order assess this, over last 3 years, numerous studies evaluated impact MNPL ingestion on homeostasis rodents. This comprehensive review reports preclinical published January 2021 2024, analyzes contributions shortcomings. shows evidence is accumulating toxicity spherical MNPLs, which lead pro-inflammatory, pro-oxidative, barrier-disruptive dysbiotic effects. However, available literature has addressed only minor part health issues MNPLs. Many parameters contributing need better taken into account studies. Particular attention should paid improve representativeness consider susceptibility factors toxicity, generated especially by underlying pathology or pathological imprinting.

Language: Английский

Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases DOI
Shuang Liu,

Yinling He,

Yin Jia

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 134054 - 134054

Published: March 15, 2024

Language: Английский

Citations

32
Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities DOI Creative Commons
Haipeng Huang, Jiaqi Hou,

Mingxiao Li

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(4)

Published: Jan. 22, 2025

Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting regular physiological processes organs. Nanoscale plastics can breach blood-brain barrier, leading to neurotoxic effects. How cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques investigate within vivo. We show that circulating are phagocytosed lead these cells obstruction capillaries cortex. These blockages as thrombus formation reduced blood flow neurological abnormalities mice. Our data reveal a mechanism which disrupt tissue function indirectly through regulation cell interference with local circulation, rather than direct penetration. revelation offers lens comprehend toxicological implications invade bloodstream.

Language: Английский

Citations

6
Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions DOI
Xiaoyu Cai,

Fujia Ren,

Yao Yao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114034 - 114034

Published: Jan. 12, 2025

Language: Английский

Citations

2
Combined effects of a high-fat diet and polyethylene microplastic exposure induce impaired lipid metabolism and locomotor behavior in larvae and adult zebrafish DOI
Seenivasan Boopathi,

B. Haridevamuthu,

Edrea Mendonca

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 902, P. 165988 - 165988

Published: Aug. 7, 2023

Language: Английский

Citations

31
Chronic exposure to polystyrene nanoplastics induces intestinal mechanical and immune barrier dysfunction in mice DOI Creative Commons

Lan Li,

Xin Lv,

Jing He

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 269, P. 115749 - 115749

Published: Nov. 30, 2023

Micro(nano)plastics are prevalent in the environment, and prolonged exposure to them represents a threat human health. The goal of this study is assess health risk long-term nanoplastics (NPs) at environmental concentrations on intestinal mechanical immune barrier mice. In study, mice were provided drinking water containing polystyrene NPs (PS-NPs; 0.1, 1, 10 mg·L

Language: Английский

Citations

26
Polylactic acid micro/nanoplastic-induced hepatotoxicity: Investigating food and air sources via multi-omics DOI Creative Commons
Hua Zha, Shengyi Han, Ruiqi Tang

et al.

Environmental Science and Ecotechnology, Journal Year: 2024, Volume and Issue: 21, P. 100428 - 100428

Published: May 3, 2024

Micro/nanoplastics (MNPs) are detected in human liver, and pose significant risks to health. Oral exposure MNPs derived from non-biodegradable plastics can induce toxicity mouse liver. Similarly, nasal cause airway dysbiosis mice. However, the hepatotoxicity induced by foodborne airborne biodegradable remains poorly understood. Here we show hepatotoxic effects of polylactic acid (PLA) through multi-omics analysis various biological samples mice, including gut, fecal, nasal, lung, blood samples. Our results that both PLA compromise liver function, disrupt serum antioxidant activity, pathology. Specifically, lead gut microbial dysbiosis, metabolic alterations serum, transcriptomic changes. Airborne affect lung microbiota, alter metabolites, transcriptomics. The Lachnospiraceae_NK4A136_group is a potential biomarker for MNP exposure, while unclassified

Language: Английский

Citations

14
Microplastic environmental behavior and health risk assessment: a review DOI
Jialin Lei,

Qianwen Ma,

Xiaomeng Ding

et al.

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(6), P. 2913 - 2941

Published: Aug. 20, 2024

Language: Английский

Citations

14
Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice DOI Creative Commons
H Weng, Li Deng, Tianyuan Wang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 7, 2024

Abstract Climate and environmental changes threaten human mental health, but the impacts of specific conditions on neuropsychiatric disorders remain largely unclear. Here, we show impact a humid heat environment brain gut microbiota using conditioned housing male mouse model. We demonstrate that can cause anxiety-like behaviour in mice. Microbial 16 S rRNA sequencing analysis reveals caused dysbiosis (e.g., decreased abundance Lactobacillus murinus ), metabolomics an increase serum levels secondary bile acids lithocholic acid). Moreover, increased neuroinflammation is indicated by elevated expression proinflammatory cytokines cortex, activated PI3K/AKT/NF-κB signalling microglial response cortex. Strikingly, transplantation from mice reared readily recapitulates these abnormalities germ-free mice, are markedly reversed administration. Human samples collected during season also decrease acid concentration. In conclusion, induced drives progression anxiety impairing metabolism enhancing neuroinflammation, probiotic administration potential therapeutic strategy for disorders.

Language: Английский

Citations

10
Genotoxic and neurotoxic potential of intracellular nanoplastics: A review DOI
Claudio Casella, Santiago Ballaz

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(11), P. 1657 - 1678

Published: March 17, 2024

Abstract Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) 1–100‐nm size, thereby littering the environment and posing a threat to wildlife human health. Research on NPL contamination has up now focused ecotoxicology effects pollution rather than health risks. This review aimed speculate about possible properties carcinogenic neurotoxic as pollutants. Given their low‐dimensional size high surface ratio, NPLs can easily penetrate biological membranes cause functional structural damage in cells. Once inside cell, interrupt autophagy flux cellular debris, alter proteostasis, provoke mitochondrial dysfunctions, induce endoplasmic reticulum stress. Harmful metabolic processes induced by include oxidative stress (OS), ROS generation, pro‐inflammatory reactions. Depending cell cycle status, may direct DNA damage, tumorigenesis, lately carcinogenesis tissues with self‐renewal capabilities like epithelia. In cells able live longest neurons, could trigger neurodegeneration promoting toxic proteinaceous aggregates, OS, chronic inflammation. genotoxicity neurotoxicity are discussed based gathered evidence, when available, within context intracellular uptake these newcomer nanoparticles. summary, this explains how risk evaluation for benefit from accurately monitoring toxicokinetics toxicodynamics at resolution level.

Language: Английский

Citations

8
The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity? DOI

Yanxu Zheng,

Shengchao Xu, Jingyu Liu

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 504, P. 153799 - 153799

Published: April 11, 2024

Language: Английский

Citations

8