The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 176798 - 176798
Published: Oct. 9, 2024
Language: Английский
Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108876 - 108876
Published: July 6, 2024
Air pollution is recognized as a modifiable risk factor for dementia, and recent evidence suggests that improving air quality could attenuate cognitive decline reduce dementia risk. However, studies have yet to explore the effects of improved on brain structures. This study aims investigate impact reduction functions structural differences among cognitively normal older adults.
Language: Английский
Citations
4
Movement Disorders, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 27, 2024
Abstract The age‐standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes need identify modifiable risk factors PD, which could form a logical entry point for prevention PD. World Health Organization (WHO) recommended reducing exposure specific environmental that have been reported be associated with in particular pesticides, trichloroethylene (TCE), air pollution. In this review we critically evaluate epidemiological biological evidence on associations these PD whether putative are causal. We conclude when considered isolation, it difficult determine causal, large part because decades‐long lag between relevant exposures incidence manifest However, tandem from complementary research lines (such as animal models), increasingly likely reflect harmful causal effects. Fundamentally, whilst highlight some gaps require further attention, believe current base sufficiently strong enough support our call stronger policy action. © 2024 Author(s). Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.
Language: Английский
Citations
4
Particle and Fibre Toxicology, Journal Year: 2025, Volume and Issue: 22(1)
Published: May 1, 2025
Both excess brain Fe and air pollution (AP) exposures are associated with increased risk for multiple neurodegenerative disorders. is a redox-active metal that abundant in AP even further elevated U.S. subway systems. Exposures to contaminants, such as Fe, lifelong could therefore contribute observed diseases, particularly via nasal olfactory uptake of ultrafine particle AP. These studies tested the hypotheses exogenously generated oxide nanoparticles reach following inhalational produce neurotoxic effects consistent diseases disorders adult C57/Bl6J mice exposed by inhalation at concentration similar those found underground systems (~ 150 µg/m3) 20 days. Olfactory bulb sections exposure chamber TEM grids were analyzed speciation. Measures included volumetric diffusivity changes; levels striatal cerebellar neurotransmitters trans-sulfuration markers; quantification frontal cortical hippocampal Aβ42, total tau, phosphorylated tau; behavioral alterations locomotor activity memory. Particle speciation confirmed similarity oxides (mostly magnetite) on bulb. Alzheimer's disease (AD) like characteristics seen Fe-exposed females including diffusivity, impaired memory, accumulation tau significantly correlated errors radial arm maze. males showed volume substantia nigra pars compacta, region critical motor impairments Parkinson's (PD), conjunction reduced trigeminal nerve optic tract chiasm. Inhaled appeared lead uptake. Further, these reproduced characteristic features sex-dependent manner, evidencing AD regions PD. As such, prolonged inhaled should be considered source aging, factor diseases. The bases dichotomous sex yet unclear. Also unknown how duration affect outcome, and/or whether during early development enhances vulnerability subsequent exposures. Collectively, findings suggest regulation levels, enclosed areas stations, may have broad public health protective effects.
Language: Английский
Citations
0
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116638 - 116638
Published: June 28, 2024
Studies have highlighted a possible link between air pollution and cerebral small vessel disease (CSVD) imaging markers. However, the exact association effects of polygenic risk score (PRS) defined genetic susceptibility remains unclear. This cross-sectional study used data from UK Biobank. Participants aged 40–69 years were recruited year 2006 2010. The annual average concentrations NOX, NO2, PM2.5, PM2.5–10, PM2.5 absorbance, PM10, estimated, joint exposure to multiple pollutants was reflected in index (APEX). Air pollutant classified into low (T1), intermediate (T2), high (T3) tertiles. Three CSVD markers used: white matter hyper-intensity (WMH), mean diffusivity (MD), fractional anisotropy (FA). first principal components MD FA measures 48 tracts analysed. sample consisted 44,470 participants median (T1–T3) as follows: 25.5 (22.4–28.7) μg/m3; NOx, 41.3 (36.2–46.7) 15.9 (15.4–16.4) 9.9 (9.5–10.3) 1.1 (1.0–1.2) per metre; 6.1 (5.9–6.3) μg/m3. Compared with group, group's APEX, levels associated increased WMH volumes, estimates (95 %CI) 0.024 (0.003, 0.044), 0.030 (0.010, 0.050), 0.032 (0.011, 0.053), respectively, after adjusting for potential confounders. PM2.5–10 group values compared that group. Sex-specific analyses revealed associations only females. Regarding combined PRS-defined markers, more profound females susceptibility, absorbance higher susceptibility. Our demonstrated may be being susceptible, modify pollutants.
Language: Английский
Citations
2
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 176798 - 176798
Published: Oct. 9, 2024
Language: Английский
Citations
1