ChemPlusChem,
Journal Year:
2023,
Volume and Issue:
88(3)
Published: Feb. 28, 2023
Abstract
The
emergence
of
multi‐drug
resistant
bacteria
strains
has
been
an
uphill
battle
in
modern
healthcare
worldwide,
due
to
the
increasing
difficulty
killing
them.
evolving
pathogenicity
led
researchers
searching
for
more
effective
antimicrobial
therapeutics
successfully
eliminate
them
without
undesirable
consequences
human
body.
In
recent
years,
photodynamic
therapy
(APDT),
obsolete
technique
cancer
treatments,
reported
eradicate
and
biofilm‐related
infections.
principle
solely
relies
on
photosensitizers
(PSs)
generating
reactive
oxygen
species,
presence
light,
destroy
pathogens.
Thus,
it
can
target
a
broad
spectrum
microorganisms,
owing
indirect
interaction
between
PSs
bacteria,
resulting
less
likelihood
development
drug
strains.
This
review
will
focus
progress
APDT
last
five
years
some
future
perspectives
APDT.
mechanism
against
biofilms,
various
used
APDT,
common
multidrug‐resistant
be
briefly
introduced.
vivo
applications
several
types
bacterial
infections
that
includes
periodontitis,
wound
infections,
keratitis,
endophthalmitis
tuberculosis
summarized
detail.
Cells,
Journal Year:
2023,
Volume and Issue:
12(1), P. 199 - 199
Published: Jan. 3, 2023
is
an
important
Gram-negative
opportunistic
pathogen
which
causes
many
severe
acute
and
chronic
infections
with
high
morbidity,
mortality
rates
as
40%.
What
makes
Crystals,
Journal Year:
2022,
Volume and Issue:
12(5), P. 603 - 603
Published: April 25, 2022
The
high
prevalence
of
nosocomial
bacterial
resistance
contributes
to
significant
mortality
and
morbidity
around
the
world;
thus,
finding
novel
antibacterial
agents
is
vital
concern.
Accordingly,
present
study
attempted
synthesize
silver
nanoparticles
(AgNPs)
using
a
green
approach.
Aqueous
leaf
extract
Origanum
majorana
was
used
AgNPs
efficiency
against
multidrug
resistant
strains
detected.
Characterization
biogenic
performed
ultraviolet-visible
spectrophotometry
(UV-Vis),
transmission
electron
microscopy
(TEM),
energy
dispersive
X-ray
spectroscopy
(EDX),
Fourier
transform
infrared
(FT-IR)
analysis,
diffraction
analysis
(XRD).
disc
diffusion
method
detect
activity
three
multidrug-resistant
strains.
Preliminary
UV-Vis
revealed
biosynthesis
due
peak
formation
at
374
nm,
corresponding
surface
plasmon
resonance
(SPR)
AgNPs.
TEM
micrographs
detected
synthesis
small
with
an
average
particle
size
26.63
nm.
EDX
presence
following
elements:
oxygen
(3.69%),
carbon
(2.93%),
aluminum
(1.29),
silicon
(2.83%),
chloride
(17.89%),
(71.37%).
Furthermore,
XRD
peaks
2
theta
(θ)
degrees
38.18°,
44.36°,
64.35°,
77.54°,
assigned
planes
crystals
(111),
(200),
(220),
(311),
respectively.
Collectively,
these
findings
affirm
potential
physicochemical
characteristics.
antimicrobial
indicated
that
Klebsiella
pneumoniae
strain
most
susceptible
concentrations
50
100
µg/disk,
inhibitory
zones
21.57
24.56
mm,
minimum
concentration
(MIC)
found
be
10
µg/mL,
while
bactericidal
(MBC)
20
µg/mL.
In
conclusion,
aqueous
O.
mediated
sized
AgNPs,
effectiveness
pathogens.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(11)
Published: Jan. 30, 2023
Abstract
Osteomyelitis
is
a
destructive
disease
of
bone
tissue
caused
by
infection
with
pathogenic
microorganisms.
Because
the
complex
and
long‐term
abnormal
conditions,
osteomyelitis
one
refractory
diseases
in
orthopedics.
Currently,
anti‐infective
therapy
primary
modality
for
addition
to
thorough
surgical
debridement.
However,
bacterial
resistance
has
gradually
reduced
benefits
traditional
antibiotics,
development
advanced
antibacterial
agents
received
growing
attention.
This
review
introduces
main
targets
treating
osteomyelitis,
including
cell
wall,
membrane,
intracellular
macromolecules,
energy
metabolism,
focuses
on
their
mechanisms,
predicts
prospects
clinical
applications.
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(10), P. 7668 - 7758
Published: May 7, 2024
Covalent
inhibitors
and
other
types
of
covalent
modalities
have
seen
a
revival
in
the
past
two
decades,
with
variety
new
targeted
drugs
having
been
approved
recent
years.
A
key
feature
such
molecules
is
an
intrinsically
reactive
group,
typically
weak
electrophile,
which
enables
irreversible
or
reversible
formation
bond
specific
amino
acid
target
protein.
This
often
called
"warhead",
critical
determinant
ligand's
activity,
selectivity,
general
biological
properties.
In
2019,
we
summarized
emerging
re-emerging
warhead
chemistries
to
cysteine
acids
(Gehringer,
M.;
Laufer,
S.
A.
J.
Med.
Chem.
62,
5673−5724;
DOI:
10.1021/acs.jmedchem.8b01153).
Since
then,
field
has
rapidly
evolved.
Here
discuss
progress
on
warheads
made
since
our
last
Perspective
their
application
medicinal
chemistry
chemical
biology.
Molecular & Cellular Proteomics,
Journal Year:
2024,
Volume and Issue:
23(3), P. 100737 - 100737
Published: Feb. 13, 2024
Personalized
medicine
can
reduce
adverse
effects,
enhance
drug
efficacy,
and
optimize
treatment
outcomes,
which
represents
the
essence
of
personalized
in
pharmacy
field.
Protein
drugs
are
crucial
field
therapy
currently
mainstay,
possess
higher
target
specificity
biological
activity
compared
to
small-molecule
chemical
drugs,
making
them
efficient
regulating
disease-related
processes,
have
significant
potential
development
drugs.
Currently,
protein
designed
developed
for
specific
targets
based
on
patient-specific
data.
However,
due
rapid
two-dimensional
gel
electrophoresis
(2DGE)
mass
spectrometry
(MS),
it
is
now
widely
recognized
that
a
canonical
actually
includes
multiple
proteoforms,
differences
between
these
proteoforms
will
result
varying
responses
The
variation
effects
different
be
impact
even
alter
intended
benefit
drug,
potentially
harmful
instead
lifesaving.
As
result,
we
propose
should
shift
from
being
targeted
through
lens
(proteomics)
proteoform
(proteoformics).
This
enable
better
equipped
meet
patients'
needs
disease
characteristics.
With
further
proteoformics,
individualized
therapy,
especially
aimed
at
as
target,
improve
understanding
mechanisms,
discovery
new
signaling
pathways,
provide
theoretical
basis
aid
doctors
conducting
health
risk
assessments
more
cost-effective
prevention
strategies
conducted
by
artificial
intelligence/machine
learning,
promote
technological
innovation,
convenient
tailored
patient
profile,
affected
individuals
society
large.
Small,
Journal Year:
2024,
Volume and Issue:
20(10)
Published: Jan. 4, 2024
Abstract
Biofilm‐associated
infections
are
one
of
the
most
challenging
healthcare
threats
for
humans,
accounting
80%
bacterial
infections,
leading
to
persistent
and
chronic
infections.
The
conventional
antibiotics
still
face
their
dilemma
poor
therapeutic
effects
due
high
tolerance
resistance
led
by
biofilm
barriers.
Nanotechnology‐based
antimicrobials,
nanoparticles
(NPs),
paid
attention
extensively
considered
as
promising
alternative.
This
review
focuses
on
whole
journey
NPs
against
biofilm‐associated
clarify
it
clearly,
is
divided
into
four
processes
in
sequence
1)
Targeting
biofilms,
2)
Penetrating
barrier,
3)
Attaching
cells,
4)
Translocating
through
cell
envelope.
Through
outlining
compositions
properties
biofilms
bacteria
recent
advances
present
strategies
each
process
comprehensively
discussed
combat
well
combined
these
with
drug
resistance,
aiming
guide
rational
design
facilitate
wide
application
