RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(26), P. 18453 - 18458
Published: Jan. 1, 2024
Asymmetric
catalytic
processes
promoted
by
N-heterocyclic
carbenes
(NHCs)
hold
great
potential
for
the
sustainable
preparation
of
chiral
molecules.
However,
catalyzing
reactions
manipulating
reactive
intermediates
is
challenging.
We
report
herein
that
known
NHC-catalyzed
[3
+
2]
annulation
reaction
between
ketimine
and
enal
can
also
be
turned
into
a
[2
3]
highly
enantioselective
direct
synthesis
trifluoroethyl
3,2'-spirooxindole
γ-lactams
(4)
through
timely
catalysis
intermediates.
DFT
calculations
revealed
this
transformation
included
key
step
nucleophilic
attack
Breslow
intermediate
M2
derived
from
NHC
(2)
to
unattacked
(1).
Our
study
demonstrates
it
possible
tune
desired
selectivities
dynamic
catalysts
Saudi Pharmaceutical Journal,
Journal Year:
2024,
Volume and Issue:
32(7), P. 102124 - 102124
Published: June 2, 2024
Natural
products
(NPs)
play
an
irreplaceable
role
in
the
intervention
of
various
diseases
and
have
been
considered
a
critical
source
drug
development.
Many
new
pharmacodynamic
compounds
with
potential
clinical
applications
recently
derived
from
NPs.
These
range
small
molecules
to
polysaccharides,
polypeptides,
proteins,
self-assembled
nanoparticles,
extracellular
vesicles.
This
review
summarizes
active
substances
found
The
investigation
NPs
can
potentiate
development
promote
in-depth
comprehension
mechanism
action
that
be
beneficial
prevention
treatment
human
diseases.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 22, 2024
Pancreatic
cancer
(PC)
is
a
highly
aggressive
malignancy
with
rising
mortality
rates
globally.
Its
diagnosis
often
challenging
due
to
its
asymptomatic
nature
in
the
early
stages.
Consequently,
most
patients
receive
poor
prognosis,
low
survival
within
5
years,
as
disease
typically
detected
at
an
advanced
stage,
complicating
effective
treatment.
Flavonoids,
especially
those
derived
from
traditional
Chinese
herbal
medicines,
have
attracted
considerable
attention
for
their
potent
anti-PC
properties.
This
review
highlights
therapeutic
potential
of
these
bioactive
compounds,
which
modulate
key
biological
pathways,
making
them
promising
candidates
PC
intervention.
Their
mechanisms
action
include
regulation
autophagy,
apoptosis,
cell
growth,
epithelial-mesenchymal
transition,
and
oxidative
stress,
well
enhancing
chemotherapeutic
sensitivity,
exerting
antiangiogenic
effects,
potentially
boosting
immunomodulatory
responses.
The
demonstrated
benefits
natural
compounds
management
spurred
extensive
academic
interest.
Beyond
role
anti-cancer
agents,
flavonoids
may
provide
both
preventive
advantages
PC,
resonating
core
principles
medicine
prevention
holistic
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 3121 - 3141
Published: July 1, 2024
As
a
traditional
Chinese
medicine
monomer
derived
from
Tripterygium
wilfordii
Hook.f.
with
potential
anticancer
activity,
celastrol
can
induce
ferroptosis
in
hepatic
stellate
cells
and
inhibit
their
activation
to
alleviate
liver
fibrosis.
Activation
of
effectively
Hepatocellular
carcinoma
(HCC).
Whether
inhibits
HCC
by
inducing
remains
be
studied.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(10)
Published: June 20, 2024
Abstract
Tetrandrine
(TET)
is
a
natural
bis‐benzylisoquinoline
alkaloid
isolated
from
Stephania
species
with
wide
range
of
biological
and
pharmacologic
activities;
it
mainly
serves
as
an
anti‐inflammatory
agent
or
antitumor
adjuvant
in
clinical
applications.
However,
limitations
such
prominent
hydrophobicity,
severe
off‐target
toxicity,
low
absorption
result
suboptimal
therapeutic
outcomes
preventing
its
widespread
adoption.
Nanoparticles
have
proven
to
be
efficient
devices
for
targeted
drug
delivery
since
drug‐carrying
nanoparticles
can
passively
transported
the
tumor
site
by
enhanced
permeability
retention
(EPR)
effects,
thus
securing
niche
cancer
therapies.
Great
progress
has
been
made
nanocarrier
construction
TET
due
their
outstanding
advantages
increased
water‐solubility,
improved
biodistribution
blood
circulation,
reduced
irritation,
combinational
therapy.
Herein,
we
systematically
reviewed
latest
advancements
TET‐loaded
respective
features
expectation
providing
perspective
guidelines
future
research
potential
applications
TET.
