Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment DOI
Iman A. Y. Ghannam, Islam H. Ali, Rasha Z. Batran

et al.

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Language: Английский

Molecular docking approach for the design and synthesis of new pyrazolopyrimidine analogs of roscovitine as potential CDK2 inhibitors endowed with pronounced anticancer activity DOI

Ola Alaa Hamed,

Nehad A. El-Sayed,

Walaa R. Mahmoud

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 147, P. 107413 - 107413

Published: April 30, 2024

Language: Английский

Citations

7
Novel benzenesulfonamides as dual VEGFR2/FGFR1 inhibitors targeting breast cancer: Design, synthesis, anticancer activity and in silico studies DOI
Rasha M. Hassan, Islam H. Ali, Ahmed M. El Kerdawy

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 152, P. 107728 - 107728

Published: Aug. 17, 2024

Language: Английский

Citations

7
Utility of sulfachloropyridazine in the synthesis of novel anticancer agents as antiangiogenic and apoptotic inducers DOI

Sally S. Zahran,

Fatma A. Ragab,

Aiten M. Soliman

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 148, P. 107411 - 107411

Published: April 30, 2024

Language: Английский

Citations

5
Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis DOI
Lei Ma, Junyuan Tang, Fangyuan Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116728 - 116728

Published: July 30, 2024

Language: Английский

Citations

4
Exploring anticancer properties of new triazole-linked benzenesulfonamide derivatives against colorectal carcinoma: Synthesis, cytotoxicity, and in silico insights DOI
Belma Zengin Kurt, Özge Özmen, Dilek Öztürk Civelek

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 119, P. 118060 - 118060

Published: Jan. 5, 2025

Language: Английский

Citations

0
Peroxisome proliferator-activated receptors (PPARs) agonists as promising neurotherapeutics DOI
Iman A. Y. Ghannam, Rasha M. Hassan, Mohammed S. Abdel‐Maksoud

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108226 - 108226

Published: Jan. 1, 2025

Language: Английский

Citations

0
Design and synthesis of novel pyrimidine-pyrazole hybrids with dual anticancer and anti-inflammatory effects targeting BRAFV600E and JNK DOI Creative Commons
Mohammed S. Abdel‐Maksoud, Hebatollah E. Eitah, Rasha M. Hassan

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract Two new series of pyrimidinyl ethyl pyrazoles derivatives 13a–f and 14a–f were designed synthesized to possess both anticancer effect by inhibiting BRAFV600E anti-inflammatory JNK isoforms. The structure the compounds was generated from hybridization two main moieties. moiety reported inhibitors, pyrazole isoforms inhibitors. final tested on BRAFV600E, JNK1, JNK2, JNK3 measure their kinases inhibitory effect. Compound 14c showed highest activity with IC 50 = 0.51 μM, 0.53 1.02 0.009 μM JNK3,and respectively. All over four cancer cell lines related target enzymes. 14d most potent all 0.87 0.91, 0.42 0.63 MOLT-4, K-562, SK-MEL-28, A375 lines, ability inhibit MEK1/2 ERK1/2 phosphorylation performed using western blot. cycle analysis compound line revealed that arrested growth at G0-G1 phase. remarkably decreased migration compared control group in traditional test. Compounds significant nitric oxide release PGE2 production raw 264.7 macrophages. 13d 1 4d exhibited high iNOS COX-2 COX-1. Finally, TNF-alpha IL-6 determined. Graphical abstract synthesized. able BRAFV600E. play a key role inflammatory disorders. Final for activities.

Language: Английский

Citations

0
Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway DOI
Walaa Hamada Abd‐Allah, Mohammed S. Abdel‐Maksoud, Marawan A. Elbaset

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 159, P. 108357 - 108357

Published: March 10, 2025

Language: Английский

Citations

0
Identification of novel thiazolidine-4-one based hits as potential PPARγ modulators through in silico workflow and validation through in vitro studies DOI
Tathagata Pradhan, Ojasvi Gupta, Gita Chawla

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142391 - 142391

Published: April 1, 2025

Language: Английский

Citations

0
Design, synthesis and anti-inflammatory assessment of certain substituted 1,2,4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors DOI

Mai I. Abo-Elmagd,

Rasha M. Hassan, Mona E. Aboutabl

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107577 - 107577

Published: June 18, 2024

Language: Английский

Citations

3