Molecular underpinnings of pancreatic cancer: Innovations in treatment and future perspectives DOI Creative Commons
Mesut Tez, Eda Şahingöz,

Fahri Martlı

et al.

Gastrointestinal Tract, Journal Year: 2023, Volume and Issue: 1

Published: Dec. 26, 2023

This review would delve into the latest developments in molecular landscape of pancreatic cancer and how this knowledge can be applied to treatments. It could particularly highlight emerging therapies like immunotherapy, genetic profiling analyses, targeted treatment approaches. Furthermore, it assess recent research on early detection prevention strategies for cancer, providing insights future outlook. significant interest value researchers, healthcare professionals, anyone seeking understand current state innovations.

Language: Английский

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements DOI Creative Commons
Islam Hamad, Amani A. Harb, Yasser Bustanji

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 400 - 400

Published: March 14, 2024

Lipid-bilayer-based liposomes are gaining attention in scientific research for their versatile role drug delivery. With amphiphilic design, efficiently encapsulate and deliver drugs to targeted sites, offering controlled release. These artificial structures hold great promise advancing cancer therapy methodologies. Bibliometric analyzes systematic literary data statistically. This study used bibliometric indicators examine, map, evaluate the applications of therapy. A Scopus search was conducted identify all English-language peer-reviewed publications on within past twenty years. were calculated using VOSviewer Biblioshiny. We produced thematic, conceptual, visualization charts. total 14,873 published documents obtained. The procedure keyword mapping has effectively identified main areas concentration prevailing trends this specific field study. significant clusters discovered through theme hotspot analyses encompassed many topics such as use multiple strategies chemotherapy different forms cancer, pharmacokinetics nanomedicine, well investigation delivery, cytotoxicity, gene Liposomes employed delivery systems so selectively target cells improve bioavailability anticancer drugs. work showcased capacity tailor these accurate by including potent medications. Our findings not only bring latest progress utilizing treatment but also underscore vital need ongoing research, collaborative efforts, effective translation breakthroughs into tangible clinical applications, emphasizing dynamic evolving nature therapeutics.

Language: Английский

Citations

17
The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis DOI Creative Commons
E Wen, Yi Cao,

Shiwen He

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 3, 2024

Abstract Kaempferol (KA), an natural antioxidant of traditional Chinese medicine (TCM), is extensively used as the primary treatment for inflammatory digestive diseases with impaired redox homeostasis. Severe acute pancreatitis (SAP) was exacerbated by mitochondrial dysfunction and abundant ROS, which highlights role antioxidants in targeting function. However, low bioavailability high dosage KA leading to unavoidable side effects limits clinical transformation. The mechanisms poor largely unexplored, hindering development efficient strategies maximizing medicinal KA. Here, we engineered a novel thioketals (TK)-modified based on DSPE-PEG2000 liposomal codelivery system improving avoiding (denotes DSPE-TK-PEG2000-KA, DTM@KA NPs). We demonstrated that liposome exerts profound impacts damaging intracellular homeostasis reducing GSH depletion activating Nrf2, synergizes reinforce inhibition inadequate fission, excessive fusion mitophagy resulting inflammation apoptosis; then, restored strengthens ATP supply PAC renovation Interestingly, TK bond proved main functional structure improve above efficacy compared absence bond. Most importantly, NPs obviously suppresses death negligible vitro vivo. Mechanismly, facilitated STAT6-regulated precursor proteins transport via interacting TOM20 further promote Drp1-dependent fission Pink1/Parkin-regulated enhanced lysosomal degradation removing damaged mitochondria then reduce apoptosis. Generally, synergistically improved homeostasis, energy metabolism response regulating TOM20-STAT6-Drp1 signaling promoting SAP. Consequently, such TCM’s active ingredients-based nanomedicine strategy be expected innovative approach SAP therapy. Graphical

Language: Английский

Citations

8
Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma DOI Creative Commons
Naga Malleswara Rao Nakka,

Hari Krishnareddy Rachamala,

Ramcharan Singh Angom

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101199 - 101199

Published: Aug. 10, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease where standard-of-care chemotherapeutic drugs have limited efficacy due to the development of drug resistance and poor delivery caused by highly desmoplastic tumor microenvironment. Combining multiple in tumor-targeting carrier would be favorable approach overcome these limitations. Hence, tumor-targeted peptide (TTP) conjugated amphiphilic tri-block copolymer was developed make targeted polymer nanoparticles (TTP-PNPs) serving as vehicle for carrying gemcitabine (Gem), paclitaxel (PTX), their combination (Gem + PTX). The TTP-PNPs form empty (P), single drug-loaded [P(Gem) P(PTX)], dual [P(Gem PTX)] nanoformulations exhibited stable homogenous spherical shapes with 110-160 nm size. These demonstrated excellent stability under

Language: Английский

Citations

6
Microbial diversity and food safety in duck meat preservation: effects of nanoemulsion nutmeg seed extract with focus on proteobacteria and lactococcus DOI Creative Commons

Supamri Supamri,

Lilik Eka Radiati, Agus Susilo

et al.

CyTA - Journal of Food, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Language: Английский

Citations

0
Preparation of pH-Sensitive Astragalus Polysaccharide Nanoparticles Loaded with Paclitaxel and Evaluation of Antitumor Activity DOI
Kaibin Wang, Yanqiang Li, Xiaoliang Zhao

et al.

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 23, 2025

Language: Английский

Citations

0
Strategies and Challenges of Cytosolic Delivery of Proteins DOI

Yuanyuan Li,

Baojie Du,

Lichao Yu

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32

Published: Jan. 25, 2025

The cytosolic delivery of therapeutic proteins represents a promising strategy for addressing diseases caused by protein dysfunction. Despite significant advances, efficient remains challenging due to barriers such as cell membrane impermeability, endosomal sequestration, and instability. This review summarizes recent progress in systems, including physical, chemical, biological approaches, with particular focus on strategies that enhance escape targeting specificity. We further discuss the clinical translatability these approaches propose future directions improving efficiency safety, ultimately unlocking potential intracellular proteins.

Language: Английский

Citations

0
Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan-coated pH-sensitive liposomes DOI

Zhenjiang Zheng,

Mengfei Li,

Jianchen Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134517 - 134517

Published: Aug. 5, 2024

Language: Английский

Citations

3
Innovative Approaches to Enhancing the Biomedical Properties of Liposomes DOI Creative Commons
Ioana Lavinia Dejeu, Laura Graţiela Vicaş, Eleonora Marian

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1525 - 1525

Published: Nov. 27, 2024

Liposomes represent a promising class of drug delivery systems that enhance the therapeutic efficacy and safety various pharmaceutical agents. Also, they offer numerous advantages compared to traditional methods, including targeted specific sites, controlled release, fewer side effects. This review meticulously examines methodologies employed in preparation characterization liposomal formulations. With rising incidence adverse reactions, there is pressing need for innovative strategies prioritize selectivity, specificity, safety. Nanomedicine promises revolutionize diagnostics treatments, addressing current limitations improving disease management, cancer, which remains major global health challenge. paper aims conduct comprehensive study on interest biomedical research regarding nanotechnology its implications further applications.

Language: Английский

Citations

3
Novel erythrocyte-shaped electrosprayed nanoparticles for co-delivery of paclitaxel and osimertinib: Preparation, characterization, and evaluation DOI

Lirong Nie,

Ziwei Zheng,

Ruiqi Chen

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 200, P. 114315 - 114315

Published: May 22, 2024

Language: Английский

Citations

1
The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis DOI Creative Commons
E Wen, Yi Cao,

Shiwen He

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

Abstract Kaempferol (KA), an natural antioxidant of traditional Chinese medicine (TCM), is extensively used as the primary treatment for inflammatory digestive diseases with impaired redox homeostasis. Severe acute pancreatitis (SAP) was exacerbated by mitochondrial dysfunction and abundant ROS, which highlights role antioxidants in targeting function. However, low bioavailability high dosage KA leading to unavoidable side effects limits clinical transformation. The mechanisms poor largely unexplored, hindering development efficient strategies maximizing medicinal KA. Here, we engineered a novel thioketals (TK)-modified based on DSPE-PEG2000 liposomal codelivery system improving avoiding (denotes DSPE-TK-PEG2000-KA, DTM@KA NPs). We demonstrated that liposome exerts profound impacts damaging intracellular homeostasis reducing GSH depletion activating Nrf2, synergizes reinforce inhibition inadequate fission, excessive fusion mitophagy resulting inflammation apoptosis; then, restored strengthens ATP supply PAC renovation Interestingly, TK bond proved main functional structure improve above efficacy compared absence bond. Most importantly, NPs obviously suppresses death negligible vitro vivo. Mechanismly, facilitated STAT6-regulated precursor proteins transport via interacting TOM20 further promote Drp1-dependent fission Pink1/Parkin-regulated enhanced lysosomal degradation removing damaged mitochondria then reduce apoptosis. Generally, synergistically improved homeostasis, energy metabolism response regulating TOM20-STAT6-Drp1 signaling promoting SAP. Consequently, such TCM’s active ingredients-based nanomedicine strategy be expected innovative approach SAP therapy.

Language: Английский

Citations

0