Journal of Agricultural and Food Chemistry,
Journal Year:
2021,
Volume and Issue:
69(17), P. 5226 - 5237
Published: April 23, 2021
Citrus
flavanones
have
the
potential
to
alleviate
atherosclerosis.
The
metabolism
and
anti-atherosclerosis
signaling
pathways
of
four
citrus
(naringin,
naringenin,
hesperidin,
hesperetin)
were
compared
in
ApoE-/-
mice.
Naringin
had
most
potent
anti-atherogenic
effect,
followed
by
hesperetin
with
reductions
55.92,
34.98,
42.87,
24.70%
atherosclerotic
plaque
rate
control,
respectively.
Oral
naringin
mainly
existed
intestine
due
high
water
solubility
7-O-nohesperidoside
alleviated
atherosclerosis
enhancing
bile
acid
synthesis
gut
microbiota-FXR/FGF15-CYP7A1
pathway.
other
three
liver
after
absorption
from
intestine.
Hesperidin
upregulates
ABCA1
1.8-fold
enhance
cholesterol
reverse
transport,
while
aglycones
naringenin
inhibited
via
downregulating
HMGCR
2.4-
2.3-fold,
Hesperetin
was
more
resistant
than
existence
a
4'-methoxyl
group
relatively
weak
effects
on
alleviation
tightly
related
differences
their
vivo
pathways.
This
provides
new
insights
into
anti-atherosclerotic
mechanisms
food
functional
guidance
for
design
novel,
efficient
strategies
preventing
based
flavanones.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(15), P. 5623 - 5623
Published: July 25, 2023
This
review
describes
the
various
innovative
approaches
implemented
for
naringin
extraction
as
well
recent
developments
in
field.
Naringin
was
assessed
terms
of
its
structure,
chemical
composition,
and
potential
food
sources.
How
works
pharmacologically
discussed,
including
an
anti-diabetic,
anti-inflammatory,
hepatoprotective
substance.
Citrus
flavonoids
are
crucial
herbal
additives
that
have
a
huge
spectrum
organic
activities.
is
nutritional
flavanone
glycoside
has
been
shown
to
be
effective
treatment
few
chronic
disorders
associated
with
ageing.
fruits
contain
common
flavone
specific
pharmacological
biological
properties.
Naringin,
range
intriguing
characteristics,
abundant
citrus
fruits.
variety
biological,
medicinal,
effects.
hydrolyzed
into
rhamnose
prunin
by
naringinase,
which
also
possesses
l-rhamnosidase
activity.
D-glucosidase
subsequently
catalyzes
hydrolysis
glucose
naringenin.
known
having
antioxidant,
tumor-fighting
Numerous
test
animals
cell
lines
used
correlate
exposure
asthma,
hyperlipidemia,
diabetes,
cancer,
hyperthyroidism,
osteoporosis.
study
focused
on
many
documented
actions
in-vitro
in-vivo
experimental
preclinical
investigations,
prospective
therapeutic
advantages,
utilizing
information
presently
accessible
literature.
In
addition
pharmacokinetic
naringin’s
distribution,
different
methods,
use
cosmetic,
food,
pharmaceutical,
animal
feed
sectors
were
discussed.
Life,
Journal Year:
2022,
Volume and Issue:
13(1), P. 99 - 99
Published: Dec. 29, 2022
The
glycosides
of
two
flavonoids,
naringin
and
naringenin,
are
found
in
various
citrus
fruits,
bergamots,
tomatoes,
other
fruits.
These
phytochemicals
associated
with
multiple
biological
functions,
including
neuroprotective,
antioxidant,
anticancer,
antiviral,
antibacterial,
anti-inflammatory,
antiadipogenic,
cardioprotective
effects.
higher
glutathione/oxidized
glutathione
ratio
3-NP-induced
rats
is
attributed
to
the
ability
reduce
hydroxyl
radical,
hydroperoxide,
nitrite.
However,
although
progress
has
been
made
treating
these
diseases,
there
still
global
concerns
about
how
obtain
a
solution.
Thus,
natural
compounds
can
provide
promising
strategy
for
many
neurological
conditions.
Possible
therapeutics
neurodegenerative
disorders
include
naringenin
polyphenols.
New
experimental
evidence
shows
that
polyphenols
exert
wide
range
pharmacological
activity;
particular
attention
was
paid
diseases
such
as
Alzheimer’s
Parkinson’s
well
conditions
anxiety,
depression,
schizophrenia,
chronic
hyperglycemic
peripheral
neuropathy.
Several
preliminary
investigations
have
shown
neuroprotection.
main
objective
this
review
reflect
on
developments
understanding
molecular
mechanisms
underlying
development
potential
neuroprotective
medications.
Furthermore,
configuration
relationships
between
discussed,
their
plant
sources
extraction
methods.
Cell Discovery,
Journal Year:
2022,
Volume and Issue:
8(1)
Published: March 1, 2022
Abdominal
aortic
aneurysm
(AAA)
is
a
lethal
cardiovascular
disease,
and
there
no
proven
drug
treatment
for
this
condition.
In
study,
by
using
the
Connectivity
Map
(CMap)
approach,
we
explored
naringenin,
naturally
occurring
citrus
flavonoid,
as
putative
agent
inhibiting
AAA.
We
then
validated
prediction
with
two
independent
mouse
models
of
AAA,
calcium
phosphate
(CaPO4)-induced
C57BL/6J
mice
angiotensin
II-infused
ApoE-/-
mice.
Naringenin
effectively
blocked
formation
AAAs
progression
established
AAAs.
Transcription
factor
EB
(TFEB)
master
regulator
lysosome
biogenesis.
Intriguingly,
protective
role
naringenin
on
AAA
was
abolished
macrophage-specific
TFEB
depletion
in
Unbiased
interactomics,
combined
isothermal
titration
calorimetry
(ITC)
cellular
thermal
shift
assays
(CETSAs),
further
revealed
that
directly
bound
to
14-3-3
epsilon
TFEB-14-3-3
interaction,
therefore
promoted
nuclear
translocation
activation.
On
one
hand,
activated
lysosome-dependent
inhibition
NLRP3
inflammasome
repressed
aneurysmal
inflammation.
other
induced
TFEB-dependent
transcriptional
activation
GATA3,
IRF4,
STAT6
reparative
M2
macrophage
polarization.
summary,
derived
or
shows
promising
efficacy
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(3), P. 586 - 586
Published: Feb. 27, 2023
Citrus
(genus
L.)
fruits
are
essential
sources
of
bioactive
compounds
with
antioxidant
properties,
such
as
flavonoids.
These
polyphenolic
divided
into
subclasses,
in
which
flavanones
the
most
prominent.
Among
them,
naringenin
and
hesperidin
emerging
anticancer
potential,
especially
for
breast
cancer
(BC).
Several
mechanisms
have
been
proposed,
including
modulation
epigenetics,
estrogen
signaling,
induction
cell
death
via
regulation
apoptotic
signaling
pathways,
inhibition
tumor
invasion
metastasis.
However,
this
information
is
sparse
literature
needs
to
be
brought
together
provide
an
overview
how
can
serve
therapeutic
tools
drug
development
a
successful
co-adjuvant
strategy
against
BC.
This
review
detailed
context
highlighted
could
interfere
BC
carcinogenesis
helpful
potential
alternative
treatment.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 863 - 863
Published: March 7, 2023
Polyphenols
comprise
a
number
of
natural
substances,
such
as
flavonoids,
that
show
interesting
biological
effects.
Among
these
substances
is
naringin,
naturally
occurring
flavanone
glycoside
found
in
citrus
fruits
and
Chinese
medicinal
herbs.
Several
studies
have
shown
naringin
has
numerous
properties,
including
cardioprotective,
cholesterol-lowering,
anti-Alzheimer's,
nephroprotective,
antiageing,
antihyperglycemic,
antiosteoporotic
gastroprotective,
anti-inflammatory,
antioxidant,
antiapoptotic,
anticancer
antiulcer
Despite
its
multiple
benefits,
the
clinical
application
severely
restricted
due
to
susceptibility
oxidation,
poor
water
solubility,
dissolution
rate.
In
addition,
shows
instability
at
acidic
pH,
enzymatically
metabolized
by
β-glycosidase
stomach
degraded
bloodstream
when
administered
intravenously.
These
limitations,
however,
been
overcome
thanks
development
nanoformulations.
This
review
summarizes
recent
research
carried
out
on
strategies
designed
improve
naringin's
bioactivity
for
potential
therapeutic
applications.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
159, P. 114226 - 114226
Published: Jan. 17, 2023
Pulmonary
fibrosis
(PF)
is
a
chronic
and
irreversible
pulmonary
disease,
can
lead
to
decreased
lung
function,
respiratory
failure
even
death.
The
pathogenesis
research
treatment
strategy
of
PF
significantly
lag
behind
the
medical
progress
clinical
needs.
this
disease
remains
thorny
problem,
effective
therapeutic
drugs
are
still
limited.
Monomeric
compounds
from
traditional
Chinese
medicine
own
various
biological
activities
high
safety.
They
play
broad
part
in
treating
diseases
also
candidate
drug
for
preventing
PF.
In
paper,
we
reviewed
mechanism
action
potential
value
anti-PF
monomeric
medicine.
These
attenuate
inflammatory
response,
oxidative
stress,
epithelial
mesenchymal
transformation
other
processes
through
many
signaling
pathways,
inhibit
activation
differentiation
fibroblasts,
thus
contributing
This
review
provide
new
ideas
development
efficiency
with
low
toxicity.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 1006 - 1006
Published: March 21, 2023
As
major
public
health
concerns
associated
with
a
rapidly
growing
aging
population,
neurodegenerative
diseases
(NDDs)
and
neurological
are
important
causes
of
disability
mortality.
Neurological
affect
millions
people
worldwide.
Recent
studies
have
indicated
that
apoptosis,
inflammation,
oxidative
stress
the
main
players
NDDs
critical
roles
in
processes.
During
aforementioned
inflammatory/apoptotic/oxidative
procedures,
phosphoinositide
3-kinase
(PI3K)/protein
kinase
B
(Akt)/mammalian
target
rapamycin
(mTOR)
pathway
plays
crucial
role.
Considering
functional
structural
aspects
blood–brain
barrier,
drug
delivery
to
central
nervous
system
is
relatively
challenging.
Exosomes
nanoscale
membrane-bound
carriers
can
be
secreted
by
cells
carry
several
cargoes,
including
proteins,
nucleic
acids,
lipids,
metabolites.
significantly
take
part
intercellular
communications
due
their
specific
features
low
immunogenicity,
flexibility,
great
tissue/cell
penetration
capabilities.
Due
ability
cross
these
nano-sized
structures
been
introduced
as
proper
vehicles
for
multiple
studies.
In
present
systematic
review,
we
highlight
potential
therapeutic
effects
exosomes
context
targeting
PI3K/Akt/mTOR
signaling
pathway.
