Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke DOI Creative Commons

Xiaoxue Du,

Nashwa Amin, Linhao Xu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 17, 2023

Ischemic-induced neuronal injury arises due to low oxygen/nutrient levels and an inflammatory response that exacerbates loss. NOD-like receptor family pyrin domain-containing 3 (NLRP3) is important regulator of inflammation after ischemic stroke, with its inhibition being involved in nerve regeneration. Curcumin, a main active ingredient Chinese herbs, plays positive role repair neuroprotection by regulating the NLRP3 signaling pathway. Nevertheless, mechanisms relating how curcumin regulates inflammasome neural restoration following stroke are unknown. In this report, we summarize biological functions along neuroprotective effects underlying via impairment pathway brain injury. We also discuss medicinal interventions target potential pathways, as well possible directions for therapy penetrate blood-brain barrier (BBB) hinder stroke. This report conclusively demonstrates has properties inhibit prevent cell loss, thereby delaying progression damage.

Language: Английский

The role of microglia in the pathogenesis of diabetic-associated cognitive dysfunction DOI Creative Commons

Wenwen Xu,

Xin Yu Wang,

Xunyao Hou

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

OPINION article Front. Endocrinol., 11 January 2024Sec. Endocrinology of Aging Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1246979

Language: Английский

Citations

5
Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy DOI Creative Commons
Liuzeng Chen, Ke Wang, Xiaohan Liu

et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Feb. 29, 2024

Pterostilbene (PST) is a naturally derived stilbene compound in grapes, blueberries, and other fruits. It also natural dietary with wide range of biological activities such as antioxidant, anti-inflammatory, antitumor, so on. Structural modifications based on the chemical scaffold pterostilbene skeleton are great importance for drug discovery. In this study, skeletons were used to design novel anti-inflammatory compounds high activity low toxicity. A total 30 new found synthesised, their safety screened. Among them, E2 was most active (against NO: IC50 = 0.7 μM) than celecoxib. Further studies showed that exerted by blocking LPS-induced NF-κB/MAPK signalling pathway activation. vivo experiments revealed had good alleviating effect acute colitis mice. conclusion, may be promising lead compound.

Language: Английский

Citations

5
Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury DOI Creative Commons
Wenjun Zhang,

Chao Guo,

Yi Li

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: April 7, 2024

Acute kidney injury (AKI) is associated with a high mortality rate. Pathologically, renal ischemia/reperfusion (RIRI) one of the primary causes AKI, and hypoxia-inducible factor (HIF)-1α may play defensive role in RIRI. This study assessed 1α (HIF-1α)-mediated mitophagy protection against RIRI vitro vivo. The human tubular cell line HK-2 was used to assess hypoxia/reoxygenation (H/R)-induced through different assays, including western blotting, immunofluorescence staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), reactive oxygen species (ROS) measurement. Additionally, rat model established for evaluation by histopathology, Doppler ultrasound, transmission electron microscopy confirm data. selective HIF-1α inhibitor LW6 reduced H/R-induced but increased apoptosis ROS production. Moreover, H/R treatment enhanced expression FUN14 domain-containing 1 (FUNDC1) protein. FUNDC1 overexpression reversed effects on altered light chain 3 (LC3) BII voltage-dependent anion channels as well blocked inhibition cells. Pretreatment roxadustat, novel oral inhibitor, led decreased In conclusion, HIF-1α/FUNDC1 signaling pathway mediates H/R-promoted mitophagy, whereas this protects cells from thus aggravating apoptosis, Accordingly, roxadustat protect RIRI-related AKI.

Language: Английский

Citations

5
The role of MAPK/NF-κB-associated microglial activation in T-2 toxin-induced mouse learning and memory impairment DOI

Na Li,

Chunyan Yao,

Jun Diao

et al.

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 174, P. 113663 - 113663

Published: Feb. 10, 2023

Language: Английский

Citations

11
Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke DOI Creative Commons

Xiaoxue Du,

Nashwa Amin, Linhao Xu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 17, 2023

Ischemic-induced neuronal injury arises due to low oxygen/nutrient levels and an inflammatory response that exacerbates loss. NOD-like receptor family pyrin domain-containing 3 (NLRP3) is important regulator of inflammation after ischemic stroke, with its inhibition being involved in nerve regeneration. Curcumin, a main active ingredient Chinese herbs, plays positive role repair neuroprotection by regulating the NLRP3 signaling pathway. Nevertheless, mechanisms relating how curcumin regulates inflammasome neural restoration following stroke are unknown. In this report, we summarize biological functions along neuroprotective effects underlying via impairment pathway brain injury. We also discuss medicinal interventions target potential pathways, as well possible directions for therapy penetrate blood-brain barrier (BBB) hinder stroke. This report conclusively demonstrates has properties inhibit prevent cell loss, thereby delaying progression damage.

Language: Английский

Citations

11