Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107258 - 107258

Published: June 21, 2024

Several cardiovascular illnesses are associated with aberrant activation of cellular pyroptosis, ferroptosis, necroptosis, cuproptosis, disulfidptosis and macrophage polarisation as hallmarks contributing to vascular damage abnormal cardiac function. Meanwhile, these three novel forms dysfunction closely related mitochondrial homeostasis. Mitochondria the main organelles that supply energy maintain Mitochondrial stability is maintained through a series regulatory pathways, such fission, fusion mitophagy. Studies have shown (e.g., impaired dynamics mitophagy) promotes ROS production, leading oxidative stress, which induces M1 phenotypic polarisation. Therefore, an in-depth knowledge dynamic regulation mitochondria during necessary understand disease development. This paper systematically summarises impact changes in mitophagy on regulating dysfunctions promote understanding pathogenesis diseases provide corresponding theoretical references for treating diseases.

Language: Английский

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A two-center prospective cohort study of serum RIP-3 as a potential biomarker in relation to severity and prognosis after severe traumatic brain injury

Neurosurgical Review, Journal Year: 2024, Volume and Issue: 47(1)

Published: Aug. 14, 2024

Language: Английский

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Death at a funeral: Activation of the dead enzyme, MLKL, to kill cells by necroptosis

Current Opinion in Structural Biology, Journal Year: 2024, Volume and Issue: 88, P. 102891 - 102891

Published: July 26, 2024

Necroptosis is a lytic form of programmed cell death implicated in inflammatory pathologies, leading to intense interest the underlying mechanisms and therapeutic prospects. Here, we review our current structural understanding how terminal executioner pathway, dead kinase, mixed lineage kinase domain-like (MLKL), converted from dormant killer by upstream regulatory RIPK3. RIPK3-mediated phosphorylation MLKL's pseudokinase domain toggles molecular switch that induces dissociation cytoplasmic platform, assembly MLKL oligomers, trafficking plasma membrane, where activated accumulates permeabilises lipid bilayer induce death. We highlight gaps mechanistic knowledge activation, diverge between species, power modelling advancing insights.

Language: Английский

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Comparison and analysis for exclusively expressed sites of milk fat globule membrane phosphoproteins between human and bovine milk based on label-free phosphoproteomic

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107328 - 107328

Published: Feb. 1, 2025

Language: Английский

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Evaluation of Prognostic Implication of Serum Mixed Lineage Kinase Domain‐Like Protein in Acute Primary Supratentorial Intracerebral Hemorrhage: A Multicenter Prospective Cohort Study

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Abstract Objective Mixed lineage kinase domain‐like protein (MLKL) is a key component of necroptosis. Here, serum MLKL levels were measured with the intent to assess its prognostic significance in acute intracerebral hemorrhage (ICH). Methods A collective 161 patients primary supratentorial ICH and 73 controls enlisted this multicenter prospective cohort study. Serum at admission all patients, study entry controls, on post‐ICH days 1, 3, 5, 7, 10, 15 patients. Multivariate analyses adopted relationships between levels, severity, early neurological deterioration (END), poststroke 6‐month modified Rankin Scale (mRS) scores, poor prognosis (mRS scores 3–6). Results Patients, relative had significantly promoted from until Day 15, peaking value 3 ( p < 0.001). Admission independently correlated National Institutes Health Stroke (NIHSS) (beta, 0.133; 95% confidence interval (CI), 0.088–0.178; = 0.011), hematoma volume 0.051; 95%CI, 0.037–0.064; 0.001), mRS 0.707; 0.487–0.927; 0.023), as well predicted END (odds ratio, 1.902; 1.229–2.945; 0.014) 2.286; 1.324–3.946; 0.038). linearly connected risks > 0.05) 0.05), no interactions age, gender, hypertension, so forth (all possessed similar areas under receiver operating characteristic curve NIHSS 0.05). The models integrating graphically represented by nomogram good consistency calibration curve. Conclusions are markedly increased shortly following ICH, may accurately mirror disease efficaciously anticipate six‐month bad strengthening biomarker prospect ICH.

Language: Английский

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A prospective cohort study regarding usability of serum RIPK3 as a biomarker in relation to early hematoma growth and neurological outcomes after acute intracerebral hemorrhage

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 562, P. 119850 - 119850

Published: July 6, 2024

Language: Английский

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Silibinin Induces Both Apoptosis and Necroptosis with Potential Anti-tumor Efficacy in Lung Cancer

Anti-Cancer Agents in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(18), P. 1327 - 1338

Published: July 29, 2024

The incidence of lung cancer is steadily on the rise, posing a growing threat to human health. search for therapeutic drugs from natural active substances and elucidating their mechanism have been focus anti-tumor research.

Language: Английский

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Cancer-Associated Programmed Cell Death Mechanisms: Extended with Biochemical Markers and Experimental Approaches

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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