Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo DOI
Maling Gou, Ke Men, Shi H

et al.

Nanoscale, Journal Year: 2011, Volume and Issue: 3(4), P. 1558 - 1558

Published: Jan. 1, 2011

Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits clinical application. Nanotechnology provides method to improve the water solubility of hydrophobic drug. In this work, curcumin was encapsulated into monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles through a single-step nano-precipitation method, creating curcumin-loaded MPEG-PCL (Cur/MPEG-PCL) micelles. These Cur/MPEG-PCL were monodisperse (PDI = 0.097 ± 0.011) with mean particle size 27.3 1.3 nm, good re-solubility after freeze-drying, encapsulation efficiency 99.16 1.02%, drug loading 12.95 0.15%. Moreover, these prepared by simple reproducible procedure, making them potentially suitable for scale-up. molecularly dispersed in PCL core micelles, could be slow-released vitro. Encapsulation improved t1/2 AUC curcuminin vivo. As well as free curcumin, efficiently inhibited angiogenesis on transgenic zebrafish model. alginate-encapsulated cancer cell assay, intravenous application more tumor cell-induced angiogenesisin vivo than that curcumin. micelle-encapsulated maintained cytotoxicity C-26 colon carcinoma cellsin Intravenous micelle (25 mg kg−1curcumin) growth subcutaneous (p < 0.01), induced stronger effect 0.05). conclusion, are excellent intravenously injectable aqueous formulation curcumin; can inhibit inhibiting directly killing cells.

Language: Английский

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy DOI
Edgar Pérez‐Herrero, Alberto Fernández‐Medarde

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2015, Volume and Issue: 93, P. 52 - 79

Published: April 2, 2015

Language: Английский

Citations

1620
A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes DOI Creative Commons
Dongmei Sun, Xiaoying Zhuang,

Xiaoyu Xiang

et al.

Molecular Therapy, Journal Year: 2010, Volume and Issue: 18(9), P. 1606 - 1614

Published: June 22, 2010

Monocyte-derived myeloid cells play vital roles in inflammation-related autoimmune/inflammatory diseases and cancers. Here, we report that exosomes can deliver anti-inflammatory agents, such as curcumin, to activated vivo. This technology provides a means for drugs, target the inflammatory well overcome unwanted off-target effects limit their utility. Using delivery vehicle, provide evidence curcumin delivered by is more stable highly concentrated blood. We show specificity determined exosomes, improvement of activity achieved directing associated with therapeutic, but not toxic, effects. Furthermore, validate therapeutic relevance this technique lipopolysaccharide (LPS)-induced septic shock mouse model. further lipid alone, are required enhanced curcumin. The using drug carrier creates opportunities treatments many without significant side due innocent bystander or

Language: Английский

Citations

1428
Applications of nanoparticle systems in drug delivery technology DOI Creative Commons
Syed A. A. Rizvi, Ayman Saleh

Saudi Pharmaceutical Journal, Journal Year: 2017, Volume and Issue: 26(1), P. 64 - 70

Published: Oct. 25, 2017

The development of nanoparticle-based drug formulations has yielded the opportunities to address and treat challenging diseases. Nanoparticles vary in size but are generally ranging from 100 500 nm. Through manipulation size, surface characteristics material used, nanoparticles can be developed into smart systems, encasing therapeutic imaging agents as well bearing stealth property. Further, these systems deliver specific tissues provide controlled release therapy. This targeted sustained delivery decreases related toxicity increase patient's compliance with less frequent dosing. Nanotechnology proven beneficial treatment cancer, AIDS many other disease, also providing advancement diagnostic testing.

Language: Английский

Citations

1148
PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect DOI
Sarbari Acharya, Sanjeeb Kumar Sahoo

Advanced Drug Delivery Reviews, Journal Year: 2010, Volume and Issue: 63(3), P. 170 - 183

Published: Oct. 21, 2010

Language: Английский

Citations

1035
Curcumin—From Molecule to Biological Function DOI
Tuba Esatbeyoglu, Patricia Huebbe,

Insa M. A. Ernst

et al.

Angewandte Chemie International Edition, Journal Year: 2012, Volume and Issue: 51(22), P. 5308 - 5332

Published: May 4, 2012

Abstract Turmeric is traditionally used as a spice and coloring in foods. It an important ingredient curry gives powder its characteristic yellow color. As consequence of intense color, turmeric, or curcumin (food additive E100), food (e.g. mustard). contains the curcuminoids curcumin, demethoxycurcumin, bisdemethoxycurcumin. Recently, health properties (neuroprotection, chemo‐, cancer prevention) have gained increasing attention. Curcuminoids induce endogenous antioxidant defense mechanisms organism anti‐inflammatory activity. influence gene expression well epigenetic mechanisms. Synthetic analogues also exhibit biological This Review describes development from “traditional” to “modern” regulator.

Language: Английский

Citations

826
Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment DOI
Ornchuma Naksuriya, Siriporn Okonogi, Raymond M. Schiffelers

et al.

Biomaterials, Journal Year: 2014, Volume and Issue: 35(10), P. 3365 - 3383

Published: Jan. 16, 2014

Language: Английский

Citations

786
A Review of Curcumin and Its Derivatives as Anticancer Agents DOI Open Access

Mhd Anas Tomeh,

Roja Hadianamrei, Xiubo Zhao

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(5), P. 1033 - 1033

Published: Feb. 27, 2019

Cancer is the second leading cause of death in world and one major public health problems. Despite great advances cancer therapy, incidence mortality rates remain high. Therefore, quest for more efficient less toxic treatment strategies still at forefront current research. Curcumin, active ingredient Curcuma longa plant, has received attention over past two decades as an antioxidant, anti-inflammatory, anticancer agent. In this review, a summary medicinal chemistry pharmacology curcumin its derivatives regard to activity, their main mechanisms action, cellular targets been provided based on literature data from experimental clinical evaluation cell lines, animal models, human subjects. addition, recent drug delivery systems cells have highlighted.

Language: Английский

Citations

777
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment DOI Creative Commons
Purusotam Basnet, Nataša Škalko‐Basnet

Molecules, Journal Year: 2011, Volume and Issue: 16(6), P. 4567 - 4598

Published: June 3, 2011

Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer other chronic diseases such diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological clinical suggested that could be prevented or significantly reduced by treatment with anti-oxidant anti-inflammatory drugs, therefore, curcumin, a principal component turmeric (a curry spice) showing strong activities, might potential candidate for prevention and/or diseases. However, highly pleiotropic molecule an excellent safety profile targeting multiple evidence on molecular level, not achieve its optimum therapeutic outcome past trials, largely due to low solubility poor bioavailability. Curcumin can developed drug through improvement formulation properties delivery systems, enabling enhanced absorption cellular uptake. This review mainly focuses curcumin recent developments dosage form nanoparticulate systems possibilities application cancer.

Language: Английский

Citations

692
Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells DOI
Murali M. Yallapu, Brij K. Gupta,

Meena Jaggi

et al.

Journal of Colloid and Interface Science, Journal Year: 2010, Volume and Issue: 351(1), P. 19 - 29

Published: May 13, 2010

Language: Английский

Citations

550
Physical and Chemical Stability of Curcumin in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular Environment DOI
Mahesh Kharat,

Zheyuan Du,

Guodong Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2016, Volume and Issue: 65(8), P. 1525 - 1532

Published: Dec. 9, 2016

The utilization of curcumin as a nutraceutical in food and supplement products is often limited because its low water solubility, poor chemical stability, oral bioavailability. This study examined the impact pH, storage temperature, molecular environment on physical stability pure aqueous solutions oil-in-water emulsions. Unlike naturally occurring curcuminoid mixtures (that contain curcumin, demethoxy-curcumin, bisdemethoxy-curcumin), was highly unstable to degradation alkaline (pH ≥7.0) tended crystallize out acidic <7). These effects were attributed changes structure under different pH conditions. crystals formed relatively large (10-50 μm), which made them prone rapid sedimentation. incorporation into emulsions (30% MCT, 1 mg curcumin/g d32 ≈ 298 nm) improved dispersibility stability. After incubation at 37 °C for month, >85% retained by stored conditions <7), whereas 62, 60, 53% 7.0, 7.4, 8.0, respectively. There little change color curcumin-loaded when conditions, but their yellow faded no evidence droplet aggregation or creaming 31 days ambient temperature. results suggest that emulsion-based delivery systems may be suitable improving would facilitate application foods supplements.

Language: Английский

Citations

539