PLGA-based nanoparticles: An overview of biomedical applications

Journal of Controlled Release, Journal Year: 2012, Volume and Issue: 161(2), P. 505 - 522

Published: Feb. 4, 2012

Language: Английский

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Engineered Nanoparticles for Drug Delivery in Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2014, Volume and Issue: 53(46), P. 12320 - 12364

Published: Oct. 7, 2014

In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve number of issues associated with conventional therapeutic agents, including their poor water solubility (at least, for most anticancer drugs), lack targeting capability, nonspecific distribution, systemic toxicity, and low index. Over the past several decades, remarkable progress been made in development application engineered nanoparticles treat cancer more effectively. For example, agents have integrated optimal sizes, shapes, surface properties increase solubility, prolong circulation half-life, improve biodistribution, reduce immunogenicity. Nanoparticles payloads also favorably delivered into tumors by taking advantage pathophysiological conditions, such enhanced permeability retention effect, spatial variations pH value. Additionally, ligands (e.g., small organic molecules, peptides, antibodies, nucleic acids) added specifically target cancerous cells through selective binding receptors overexpressed on surface. Furthermore, demonstrated that multiple types drugs and/or diagnostic contrast agents) could be same carrier enable combination therapy potential overcome multidrug resistance, real-time readout treatment efficacy. It is anticipated precisely will emerge next-generation platform many other biomedical applications.

Language: Английский

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Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

Chemical Society Reviews, Journal Year: 2012, Volume and Issue: 41(7), P. 2971 - 2971

Published: Jan. 1, 2012

Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These evolved from their earlier use as biodegradable such resorbable sutures, orthopaedic implants, macroscale microscale drug delivery systems microparticles wafers controlled release depots, to multifunctional nanoparticles (NPs) capable targeting, therapeutic diagnostic agents. newer generations targeted polymeric NPs are now engineered navigate the complex vivo environment, incorporate functionalities achieving target specificity, control concentration exposure kinetics at tissue, cell, subcellular levels. Indeed this optimization pharmacology aided by careful design can lead improved safety efficacy, may be complimentary enhancements that traditionally achieved medicinal chemistry. In regard, potential result highly differentiated new class therapeutics, distinct original active drugs composition, first generation largely facilitated formulation. A greater flexibility molecules themselves also following incorporation into NPs, properties (solubility, metabolism, plasma binding, biodistribution, tissue accumulation) will no longer constrained same extent chemical but become in-part function physicochemical NP. The combination optimally designed with opens up possibility clinical outcomes not achievable administration conventional form. critical review, we aim provide insights development highlight challenges associated engineering novel including considerations NP optimization, biophysicochemical properties. Additionally, some recent examples literature, which demonstrate current trends concepts both utility (444 references).

Language: Английский

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Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Frontiers in Molecular Biosciences, Journal Year: 2020, Volume and Issue: 7

Published: Aug. 20, 2020

Nanotechnology has been extensively studied and exploited for cancer treatment as the important role of nanoparticles in drug delivery system. Compared with conventional drugs, nanoparticle-based specific advantages, including good stability, biocompatibility, enhancing permeability retention effect precise targeting. In addition, nanoparticle drugs have also shown a certain overcoming resistance cancer. The application development hybrid combined properties different lead this type drug-carrier system to further step. review, we discuss delivery, describe targeting mechanism well its function on reversing resistance.

Language: Английский

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Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

International Journal of Nanomedicine, Journal Year: 2012, Volume and Issue: unknown, P. 3445 - 3445

Published: July 1, 2012

Abstract: A targeted drug delivery system is the need of hour. Guiding magnetic iron oxide nanoparticles with help an external field to its target principle behind development superparamagnetic (SPIONs) as novel vehicles. SPIONs are small synthetic γ-Fe2O3 (maghemite) or Fe3O4 (magnetite) particles a core ranging between 10 nm and 100 in diameter. These coated certain biocompatible polymers, such dextran polyethylene glycol, which provide chemical handles for conjugation therapeutic agents also improve their blood distribution profile. The current research on opening up wide horizons use diagnostic resonance imaging well Delivery anticancer drugs by coupling functionalized site one most pursued areas cancer treatment strategies. have demonstrated efficiency nonviral gene vectors that facilitate introduction plasmids into nucleus at rates multifold those routinely available standard technologies. SPION-induced hyperthermia has been utilized localized killing cancerous cells. Despite potential biomedical application, alteration expression profiles, disturbance homeostasis, oxidative stress, altered cellular responses some SPION-related toxicological aspects require due consideration. This review provides comprehensive understanding regard method preparation, utility vehicles, concerns be resolved before they can moved from bench top bedside. Keywords: nanoparticles, SPIONs, delivery, coating, functionalization, targeting ligands, toxicity

Language: Английский

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Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

Biomaterials, Journal Year: 2014, Volume and Issue: 35(10), P. 3365 - 3383

Published: Jan. 16, 2014

Language: Английский

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Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(45)

Published: July 31, 2018

Photodynamic therapy is arising as a noninvasive treatment modality for cancer and other diseases. One of the key factors to determine therapeutic function efficiency photosensitizers (PSs). Opposed traditional PSs, which show quenched fluorescence reduced singlet oxygen production in aggregate state, PSs with aggregation-induced emission (AIE) exhibit enhanced strong photosensitization ability nanoparticles. Here, design principles AIE their biomedical applications are discussed detail, starting summary followed by comparison between highlight various strategies unique features latter. Subsequently, photodynamic cell ablation, bacteria killing, image-guided using charged PS molecular probes, nanoparticles examples. These studies have demonstrated great potential effective theranostic agents treat tumor or bacterial infection. This review hopefully will spur more research interest future translational research.

Language: Английский

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Cancer nanomedicine: from targeted delivery to combination therapy

Trends in Molecular Medicine, Journal Year: 2015, Volume and Issue: 21(4), P. 223 - 232

Published: Feb. 2, 2015

Language: Английский

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Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Nanoscale, Journal Year: 2014, Volume and Issue: 6(20), P. 11553 - 11573

Published: Jan. 1, 2014

Magnetic nanoparticles have great potential as mediators of localised heat well vehicles for drug delivery to synergistic effect thermo-chemotherapy cancer treatment.

Language: Английский

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PLGA: a Unique Polymer for Drug Delivery

Therapeutic Delivery, Journal Year: 2015, Volume and Issue: 6(1), P. 41 - 58

Published: Jan. 1, 2015

Biodegradable polymers have played an important role in the delivery of drugs a controlled and targeted manner. Polylactic-co-glycolic acid (PLGA) is one extensively researched synthetic biodegradable due to its favorable properties. It also known as 'Smart Polymer' stimuli sensitive behavior. A wide range PLGA-based drug systems been reported for treatment or diagnosis various diseases disorders. The present review provides overview chemistry, physicochemical properties, biodegradation behavior, evaluation parameters applications PLGA delivery. Different drug–polymer combinations developed into carrier are enumerated discussed.

Language: Английский

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