Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(7), P. 2053 - 2108

Published: Sept. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Language: Английский

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Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

International Journal of Nanomedicine, Journal Year: 2017, Volume and Issue: Volume 12, P. 7291 - 7309

Published: Oct. 1, 2017

Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release damaging normal cells. improve bioavailability therapeutic efficiency of drugs, while providing preferential accumulation at target site. A number nanocarriers developed; however, only a few them are clinically approved drugs intended actions targeted sites. The present review is divided into three main parts: first part presents introduction relevance in anticancer second encompasses targeting mechanisms surface functionalization on third covers description selected tumors, breast, lungs, colorectal pancreatic applications relative these This increases understanding tumor treatment promising use nanotechnology.

Language: Английский

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Nanomaterials for cancer therapy: current progress and perspectives

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: May 31, 2021

Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, electrical properties. used cancer therapy can be classified into several main categories. Targeting cells, tumor microenvironment, immune system, these nanomaterials have been modified for wide range therapies to overcome toxicity enhance drug capacity well bioavailability. Although number studies has increasing, approved nano-drugs not increased much over years. To better improve clinical translation, further research needed targeted delivery by nano-carriers reduce toxicity, permeability retention effects, minimize shielding effect protein corona. This review summarizes novel fabricated use, discusses current limitations obstacles that hinder translation from provides suggestions more efficient adoption therapy.

Language: Английский

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Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box

Molecules, Journal Year: 2015, Volume and Issue: 20(9), P. 16852 - 16891

Published: Sept. 16, 2015

The majority of heterocycle compounds and typically common fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility unique physicochemical properties, have poised them as true cornerstones medicinal chemistry. Apart from the already marketed drugs, there are many other being investigated for promising activity against several malignancies. In particular, anticancer research has been capitalizing on dynamic core scaffold these compounds. Nevertheless, any heterocyclic do not come without shortcomings. this review, we provide a concise overview active families main applications medicine. We shall focus those suitable cancer therapy while simultaneously addressing biochemical modes action, biological targets, structure-activity relationships well limitation issues use Finally, considering advent nanotechnology effective selective targeting discuss fundamental aspects considerations nanovectorization such that may improve pharmacokinetic/pharmacodynamic properties heterocycles.

Language: Английский

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Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 6013 - 6041

Published: Jan. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Language: Английский

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PLGA-Based Nanoparticles in Cancer Treatment

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Nov. 2, 2018

Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently in such setups. This review article gives an overview the properties previously reported PLGA nanoparticles (NPs), their behavior biological systems, use Strategies emphasized to target NPs tumor site passively actively. Furthermore, combination introduced that enhance accumulation and, thereby, therapeutic efficacy. In this context, huge number reports on as delivery systems treatment highlight potential carriers therapeutics encourage further translational research.

Language: Английский

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Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics

Expert Opinion on Drug Delivery, Journal Year: 2018, Volume and Issue: 16(1), P. 69 - 78

Published: Nov. 29, 2018

For many years, the controlled delivery of therapeutic compounds has been a matter great interest in field nanomedicine. Among wide amount drug nanocarriers, magnetic iron oxide nanoparticles (IONs) stand out from crowd and constitute robust nanoplatforms since they can achieve high loading as well targeting abilities stemming their remarkable properties (magnetic biological properties). These applications require precise design regarding several parameters which must be considered together order to attain highest efficacy.This short review presents recent developments cancer targeted using nanocarriers systems.The enabling efficient toward locations is one major area research field. By precisely shaping structural nanoparticles, drugs loaded onto efficiently guided selectively delivered locations. With these goals mind, special attention should given pharmacokinetics vivo behavior developed nanocarriers.

Language: Английский

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(47)

Published: Oct. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Language: Английский

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Review on nanomaterials: Synthesis and applications

Materials Today Proceedings, Journal Year: 2019, Volume and Issue: 18, P. 2182 - 2190

Published: Jan. 1, 2019

Language: Английский

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Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 3, 2021

Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate pharmacological and biopharmaceutical properties drugs. The peculiar physico-chemical technological nanomaterial-based therapeutics allowed for several successful applications treatment cancer. size, shape, charge patterning nanoscale therapeutic molecules are parameters that need be investigated modulated order promote optimize cell tissue interaction. In this review, use polymeric nanoparticles as drug delivery systems anticancer compounds, their ability efficiently localized specific tumor tissues been described. nanoencapsulation antitumor active compounds is a promising approach improve efficacy various treatments.

Language: Английский

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