Metal‐Organic Frameworks (MOFs): Classification, Synthesis, Modification, and Biomedical Applications

Small, Journal Year: 2024, Volume and Issue: 20(47)

Published: Aug. 16, 2024

Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.

Language: Английский

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Development of a Simple Voltammetric Method for Estrogens Determination (E1, E2, E3, EE2, and E2Ac) in Pharmaceuticals and Human Urine Using an Unmodified Screen‐Printed Carbon Sensor

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(5)

Published: Feb. 1, 2025

Abstract An efficient, fast, and sensitive method for the determination of estrone (E1), 17β‐estradiol (E2), estriol (E3), ethinylestradiol (EE2), β‐estradiol‐17‐acetate (E2Ac) in pharmaceutical formulations spiked human urine was developed validated using an unmodified commercial screen‐printed carbon electrode. The utilization linear sweep square wave voltammetry compared, experimental conditions were optimized. In a 6.0 mmol L −1 phosphoric acid solution, current intensity oxidation aromatic alcohol used as analytical response. peak potential each estrogen signal found between 0.62 0.67 V. detection limits to be E1, E2, E2Ac, EE2, E3 43, 25, 32, 42, 44 nmol 20, 21, 37, 53, 39 voltammetry, respectively. successfully applied estrogens drug tablets male samples. findings from this study establish strong basis future application conjunction with high‐performance liquid chromatography samples characterized by complex matrices.

Language: Английский

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Nanopore Environmental Analysis

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

As global pollution continues to escalate, timely and accurate monitoring is essential for guiding governance safeguarding public health. The increasing diversity of pollutants across environmental matrices poses a significant challenge instrumental analysis methods, which often require labor-intensive time-consuming sample pretreatment. Nanopore technology, an emerging single-molecule technique, presents promising solution by enabling the rapid identification multiple targets within complex mixtures with minimal preparation. A wide range have been characterized using natural biological nanopores or artificial solid-state nanopores, their distinct advantages include simple preparation, high sensitivity, onsite analysis. In particular, long-read nanopore sequencing has led dramatic improvements in analyses microbial communities, allows species-level taxonomic assignment amplicon sequencing, simplifies assembly metagenomes. this Perspective, we review latest advancements analyzing chemical through sensing techniques. We also explore challenges that remain rapidly evolving field provide outlook on potential transform monitoring, risk assessment, health protection.

Language: Английский

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Glass nano/micron pipette-based ion current rectification sensing technology for single cell/vivo analysis

The Analyst, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Glass nano/micron pipettes, owing to their easy preparation, unique confined space at the tip, and modifiable inner surface of can capture ion current signal caused by a single entity, making them widely used in construction highly sensitive selective electrochemical sensors for entity analysis. Compared with other solid-state nanopores, conical nano-tip causes less damage cells when inserted into them, thereby becoming powerful tool

Language: Английский

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Research Progress on Saccharide Molecule Detection Based on Nanopores

Sensors, Journal Year: 2024, Volume and Issue: 24(16), P. 5442 - 5442

Published: Aug. 22, 2024

Saccharides, being one of the fundamental molecules life, play essential roles in physiological and pathological functions cells. However, their intricate structures pose challenges for detection. Nanopore technology, with its high sensitivity capability single-molecule-level analysis, has revolutionized identification structural analysis saccharide molecules. This review focuses on recent advancements nanopore technology carbohydrate detection, presenting an array methods that leverage molecular complexity saccharides. Biological techniques utilize specific protein binding or pore modifications to trigger typical resistive pulses, enabling high-sensitivity detection monosaccharides oligosaccharides. In solid-state sensing, boronic acid modification pH gating mechanisms are employed recognition quantitative polysaccharides. The integration artificial intelligence algorithms can further enhance accuracy reliability analyses. Serving as a crucial tool we foresee significant potential application disease diagnosis, drug screening, biosensing, fostering innovative progress related research domains.

Language: Английский

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Nanofluidic Manipulation of Single Nanometric Objects: Current Progress, Challenges, and Future Opportunities

Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Application of piezoelectric sensors to aspartame determination in fluids

Industrial laboratory Diagnostics of materials, Journal Year: 2024, Volume and Issue: 90(7), P. 27 - 31

Published: July 27, 2024

The study touches the development of piezoelectric sensors based on molecularly imprinted polymers (MIPs) with an aspartame imprint. values imprinting factors and selectivity coefficients developed sensor MIP-E951 in relation to target molecules other sweeteners were calculated confirm ability MIP -951 selective detection aspartame. range determined concentrations is 1 – × 10 –3 g/liter, limit 5 –4 g/liter. When analyzing model solutions, it was found that foreign components usually present soft drinks do not interfere determination using sensor. obtained tested for drinks. Chromatographic analysis used as a reference method. results by both methods indicate piezo can be successfully liquid media. error does exceed 8%.

Language: Английский

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Determination of 3-(4-Hydroxyphenyl)lactic Acid by an Amperometric Sensor with Molecularly Imprinted Polymers

Journal of Analytical Chemistry, Journal Year: 2024, Volume and Issue: 79(11), P. 1635 - 1639

Published: Nov. 1, 2024

Language: Английский

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Nanotechnology in food safety

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 159 - 189

Published: Nov. 29, 2024

Language: Английский

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Application of Piezoelectric Sensors for the Determination of Aspartame in Fluids

Inorganic Materials, Journal Year: 2024, Volume and Issue: 60(3), P. 375 - 378

Published: March 1, 2024

Language: Английский

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