Malaysian Journal of Fundamental and Applied Sciences,
Journal Year:
2024,
Volume and Issue:
20(2), P. 347 - 359
Published: April 24, 2024
Semen
analysis
is
an
important
for
male
infertility
primary
investigation
and
manual
semen
a
conventional
method
to
assess
it.
Manual
has
been
revealed
with
accuracy
precision
limitations
due
noncompliance
guidelines
procedures.
Sperm
motility
concentration
are
the
main
indicators
pregnancy
conception
rate
hence
they
were
selected
parameters
prediction.
Convolutional
neural
network
(CNN)
benefited
computer
vision
application
industry
in
recent
years
widely
applied
research
tasks.
In
this
paper,
three-dimensional
CNN
(3DCNN)
was
designed
extract
motion
temporal
features,
which
vital
sperm
For
concentration,
since
two-dimensional
(2DCNN)
efficient
recognizing
extracting
spatial
well-established
Residual
Network
(ResNet)
architecture
adopted
customized
Multimodal
learning
approach
technique
aggregate
learnt
features
from
different
deep
that
other
forms
of
modalities,
could
provide
model
better
insights
on
their
Hence,
multimodal
receive
both
image-based
(frames
extracted
video
samples)
video-based
(stacked
frames
pre-processed
input
well-extracted
The
results
obtained
using
proposed
methodology
have
surpassed
similar
works
who
used
approach.
motility,
its
best
achieved
average
mean
absolute
error
(MAE)
8.048,
competent
Pearson’s
correlation
coefficient
(RP)
value
0.853.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
234, P. 112336 - 112336
Published: Sept. 19, 2023
Lung
cancer
is
one
of
the
most
prevalent
tumors
with
rapid
progression
and
poor
prognosis,
which
badly
affects
human
physical
mental
health.
Although
traditional
anti-cancer
therapies,
such
as
chemotherapy
radiation,
have
demonstrated
some
degree
effectiveness
in
treating
tumors,
they
remain
encumbered
by
frequent,
uncontrollable,
large
dosage
drug
administration.
Here,
we
introduced
Gefitinib-loaded
PLGA
microspheres
generated
from
microfluidics
for
lung
therapy.
The
had
a
homogeneous
shape
high
loading
rate.
Studies
shown
that
not
only
provided
greater
efficiency
sustained
release
gefitinib
but
also
protected
breakdown.
results
animal
experiments
showed
drug-loaded
could
achieve
or
even
outperform
daily
medication
less
frequency.
Therefore,
it
foreseen
will
great
potential
developing
therapies
cancer.
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(7), P. 726 - 726
Published: July 4, 2024
Male
infertility
accounts
for
approximately
40%
of
cases.
There
are
many
causes
male
infertility,
including
environmental
factors,
age,
lifestyle,
infections,
varicocele,
and
cancerous
pathologies.
Severe
oligozoospermia,
cryptozoospermia,
azoospermia
(obstructive
non-obstructive)
identified
as
severe
factor
once
considered
conditions
sterility.
Today,
in
vitro
fertilization
(IVF)
techniques
the
only
treatment
strategy
cases
which
new
methodologies
have
been
developed
manipulation
spermatozoa
to
achieve
increase
success
rates.
This
review
is
an
update
techniques,
particular
sperm
selection,
emphasizing
clinical
case-specific
methodology.
The
IVF
process
related
diagnosis,
appropriate
choice
treatment,
effective
preparation
selection.
In
fact,
selecting
best
guarantee
optimal
paternal
heritage
means
increasing
blastulation,
implantation,
ongoing
pregnancy
live
birth
rates,
resulting
greater
techniques.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 4, 2025
A
variety
of
techniques
have
been
employed
in
the
field
sperm
selection,
including
methods
based
on
density,
morphological
characteristics,
motility
membrane
integrity,
and
surface
charge.
Among
these
techniques,
density
gradient
centrifugation
(DGC)
method
stands
out
as
most
prevalent
widely
utilized
today.
However,
this
technique
involves
steps
that
linked
to
oxidative
stress
subsequent
cellular
damage.
Consequently,
alternatives
DGC
are
being
continuously
developed.
The
recently
developed
microfluidic
chip
has
also
implemented
for
selection
intracytoplasmic
injection
(ICSI).
presents
certain
disadvantages
must
be
addressed.
This
chapter
evaluates
advantages
from
past
present,
with
a
particular
focus
devices.
Journal of Pharmacy And Bioallied Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
A
BSTRACT
This
study
describes
the
disadvantages
of
centrifugation
method
along
with
utilization
high-technology
sperm
separation
to
overcome
infertility.
31-year-old
female
and
a
36-year-old
male
were
presented
primary
infertility
in
Maharashtra.
The
had
normal
hormonal
profiles;
however,
deoxyribonucleic
acid
(DNA)
fragmentation
(SDF)
index
46%,
which
may
be
due
lifestyle
factors
such
as
occupational
exposure
chemicals
alcohol
use.
contribution
rise
SDF
was
previously
conventional
density
gradient
centrifugation.
To
reduce
SDF,
put
on
two
months
treatment
including
modification
(stress
reduction,
diet
improvement,
exercise,
etc.)
antioxidants.
Following
this,
separated
through
LensHooke
CA0
device
that
avoids
reduces
oxidative
stress
DNA
damage
using
natural
motility-based
sorting
mechanism.
Post-treatment,
decreased
dramatically
17%.
couple
became
pregnant
IUI.
case
shows
effectively
lowers
while
ART
outcomes
improve.
These
results
highlight
should
implemented
modern,
minimally
invasive
procedures
for
treatment.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(10), P. 4412 - 4420
Published: Aug. 26, 2024
The
vessel-on-a-chip
has
shown
a
significant
preponderance
in
vascular
disease
research.
While
the
rarely
demonstrated
effects
of
endogenous
and/or
exogenous
stimuli
on
endothelial
glycocalyx
that
plays
critical
role
regulating
vessel
function.
Here,
an
innovative
combined
with
inverse
opal
films
was
developed
to
investigate
integrity
and
its
barrier
function
under
different
stimuli.
By
integrating
into
chip,
we
achieved
real-time
observation
vitro.
We
can
be
maintained
physiological
shear
stress,
further,
restoration
treated
sevoflurane
after
being
destroyed
by
low
stress
also
confirmed.
Thus,
it
is
clear
system
holds
considerable
promise
for
studying
mechanisms
various
diseases
provides
valuable
candidate
preclinical
drug
assessment.
Journal of Fluid Mechanics,
Journal Year:
2024,
Volume and Issue:
997
Published: Oct. 17, 2024
Understanding
the
effect
of
intricate
surface
wettability
conditions
on
microswimmers
is
crucial
for
precisely
navigating
them
across
narrow
microcirculatory
networks.
Here,
we
adopt
spherical
squirmer
model
and
Navier
slip
condition
to
delineate
microswimmer
locomotion
under
a
Poiseuille
flow
in
slit
microchannel.
Through
combined
analytical–numerical
approach
utilizing
bispherical
coordinates
superposition
technique,
resolve
slip-modulated
simultaneous
hydrodynamic
interaction
with
substrate
boundaries.
Phase
portraits
reveal
that
significantly
alters
propulsion
mechanisms,
destabilizing
centreline
stable
oscillations
pullers
beyond
threshold
length.
Superhydrophobic
surfaces
suppress
near-wall
rheotaxis
states
but
preserve
focusing,
facilitating
slip-assisted
directed
transport
without
accumulation.
Under
strong
background
flows,
subcritical
Hopf
bifurcation
emerges
at
critical
length,
transitioning
dynamics
from
coexisting
unstable
purely
behaviour.
Contrastingly,
pushers,
causes
transition
either
or
fixed-amplitude
oscillations.
Increased
length
reduces
repulsion
walls
by
enhancing
rotational
velocity
near
walls,
whereas
it
counteracts
torque
pushers.
Three-dimensional
analysis
trajectories
reveals
significant
role
out-of-plane
orientation
its
transitions
between
different
swimming
states.
The
presented
regime
maps
offer
parametric
combinations
specific
motion
behaviours,
guiding
development
smart
microfluidic
drug
delivery
systems
preventing
biofilm
deposition
biomedical
devices.
