Insights into the mechanism of carbocatalysis for peracetic acid activation: Kinetic discernment and active site identification

Water Research, Journal Year: 2022, Volume and Issue: 227, P. 119346 - 119346

Published: Nov. 8, 2022

Language: Английский

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Bisphenols in water: Occurrence, effects, and mitigation strategies

Chemosphere, Journal Year: 2023, Volume and Issue: 328, P. 138560 - 138560

Published: March 31, 2023

Language: Английский

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Dissecting ultra-processed foods and drinks: Do they have a potential to impact the brain?

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2022, Volume and Issue: 23(4), P. 697 - 717

Published: Feb. 2, 2022

Language: Английский

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Exposure to endocrine‐disrupting chemicals and implications for neurodevelopment

Developmental Medicine & Child Neurology, Journal Year: 2023, Volume and Issue: 65(8), P. 1005 - 1011

Published: Feb. 17, 2023

Abstract Human brain development is a complex multistep process that partly coordinated by the endocrine system. Any interference with system might affect this and result in deleterious outcomes. Endocrine‐disrupting chemicals (EDCs) represent large group of exogenous capacity interfering functions. In different population‐based settings, associations between exposure to EDCs, particularly prenatal life, adverse neurodevelopmental outcomes have been demonstrated. These findings are strengthened numerous experimental studies. Although mechanisms underlying these not entirely delineated, disruption thyroid hormone and, lesser extent, sex signalling shown be involved. Humans constantly exposed mixtures further research combining epidemiological settings required improve our understanding link real‐life exposures their impact on neurodevelopment.

Language: Английский

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A vision for safer food contact materials: Public health concerns as drivers for improved testing

Environment International, Journal Year: 2023, Volume and Issue: 180, P. 108161 - 108161

Published: Sept. 26, 2023

Food contact materials (FCMs) and food articles are ubiquitous in today's globalized system. Chemicals migrate from FCMs into foodstuffs, so called chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health hazardous FCCs because only individual substances used to make tested mostly for genotoxicity while endocrine disruption other hazard properties disregarded. Indeed, a known source of wide range chemicals, they likely contribute highly prevalent non-communicable diseases. can also include non-intentionally added (NIAS), which often unknown therefore subject risk assessment. To address these important shortcomings, we outline how the safety may be improved by (1) testing overall migrate, including (unknown) NIAS, finished articles, (2) expanding toxicological beyond multiple endpoints associated with diseases relevant human health. identify mechanistic testing, group chronic outcomes chemical exposure Six Clusters Disease (SCOD) propose that should their impacts on SCOD. Research focus developing robust, relevant, sensitive in-vitro assays based information linked SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics Toxicants. Implementing this vision will improve prevention exposures, FCMs.

Language: Английский

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Effects and mechanisms of bisphenols exposure on neurodegenerative diseases risk: A systemic review

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170670 - 170670

Published: Feb. 5, 2024

Language: Английский

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Adverse outcomes of the newly emerging bisphenol A substitutes

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143147 - 143147

Published: Aug. 19, 2024

BPA and its analogues are facing increasingly stringent regulations restricting their use due to the increasing knowledge of harmful effects. It is therefore expected that novel alternatives will replace them in plastic products, cans thermal paper circumvent restrictions imposed by legislation. This raises concerns about safety "BPA-free" as they contain substitutes whose has not been sufficiently assessed prior market introduction. The regulatory agencies have recognised BPAP, BPBP, BPC2, BPE, BPFL, BPG, BPP, BPPH, BPS-MAE, BPS-MPE, BP-TMC, BPZ BTUM, D-90, UU PF201 compound with insufficient data regarding safety. We demonstrate mentioned compounds present consumer food environment, thus exhibiting toxicological risk only humans, but also other species where toxic effects already described. Results silico, vitro vivo studies examining endocrine disruption show disrupt system targeting various nuclear receptors, impairing reproductive function causing such hepatotoxicity, altered behaviour impaired function. In on literally non-existent, although these commonly used papers. However, silico predicted might cause adverse well. aim this article comprehensively collate information selected illustrate potential toxicity identify gaps.

Language: Английский

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Role of endocrine disrupting chemicals in children's neurodevelopment

Environmental Research, Journal Year: 2021, Volume and Issue: 203, P. 111890 - 111890

Published: Aug. 19, 2021

Language: Английский

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A holistic assessment of the sources, prevalence, and distribution of bisphenol A and analogues in water, sediments, biota and plastic litter of the Ebro Delta (Spain)

Environmental Pollution, Journal Year: 2022, Volume and Issue: 314, P. 120310 - 120310

Published: Oct. 4, 2022

Language: Английский

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Emerging trends in the methodology of environmental toxicology: 3D cell culture and its applications

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159501 - 159501

Published: Oct. 17, 2022

Language: Английский

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