In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study DOI Creative Commons
Tuulia Hyötyläinen, Aidan McGlinchey, Samira Salihović

et al.

The Lancet Planetary Health, Journal Year: 2024, Volume and Issue: 8(1), P. e5 - e17

Published: Jan. 1, 2024

BackgroundPerfluoroalkyl and polyfluoroalkyl substances are classed as endocrine disrupting compounds but continue to be used in many products such firefighting foams, flame retardants, utensil coatings, waterproofing of food packaging. Perfluoroalkyl exposure aberrantly modulates lipid, metabolite, bile acid levels, increasing susceptibility onset severity metabolic diseases, diabetes dysfunction-associated steatotic liver disease. To date, most studies humans have focused on perfluoroalkyl-exposure effects adults. In this study we aimed show if perfluoroalkyls present the human fetal they consequences for fetus.MethodsIn cross-sectional study, livers from elective termination pregnancies at Aberdeen Pregnancy Counselling Service, Aberdeen, UK, were analysed by both targeted (bile acids perfluoroalkyl substances) combined untargeted (lipids polar metabolites) mass spectrometry based metabolomic analyses, well with RNA-Seq. Only fetuses normally progressing (determined ultrasound scan before termination), terminated non-medical reasons, women older than 16 years, fluent English, between 11 21 weeks gestation collected. Women exhibiting considerable emotional distress or whose had anomalies identified excluded. Stringent bioinformatic statistical methods partial correlation network analysis, linear regression, pathway analysis applied data investigate association hepatic pathways.FindingsFetuses included collected Dec 2, 2004, Oct 27, 2014. 78 study: all metabolomics (40 female 38 male) 57 RNA-Seq (28 29 male). Metabolites associated these varied gestational age. Conjugated markedly positively 23 amino acids, fatty sugar derivatives inversely exposure, glycolithocholic was quantified perfluoroalkyl. Furthermore, 7α-hydroxy-4-cholesten-3-one, a marker synthesis rate, strongly levels detectable early week 12.InterpretationOur shows direct evidence utero specific key products. Our results provide that potential future consequences, manifests fetus first trimester gestation. profiles changes resemble those observed perinatal exposures. Such exposures already linked susceptibility, initiation, progression, exacerbation wide range diseases.FundingUK Medical Research Council, Horizon Europe Program European Union, Seventh Framework Programme NHS Grampian Endowments grants, Partnership Assessment Risks Chemicals, Swedish Formas, Novo Nordisk Foundation, Academy Finland.

Language: Английский

Per- and polyfluoralkyl substances (PFAS) in drinking water system: Target and non-target screening and removal assessment DOI Creative Commons
Yuqing Wang, Li‐Xin Hu, Ting Liu

et al.

Environment International, Journal Year: 2022, Volume and Issue: 163, P. 107219 - 107219

Published: March 30, 2022

The massive use and the persistence of per- polyfluoroalkyl substances (PFAS) have led to their frequent detection in aquatic environments, which may further threaten drinking water safety. So far, our knowledge about occurrence PFAS system is still very limited. Here we investigated removal a using non-target, suspect target screening strategies. Sampling was performed three seasons including source, two treatment plants, tap five households. results showed 17 homologous series with 51 homologues non-target 50 potential detected screening. Probable structures were proposed for 15 high confidence levels (the first levels), seven them being reported time system. Semi-quantification on based PFAS, estimated total concentrations ranged between 4.10 17.6 ng/L. Nine out found precisely quantified (

Language: Английский

Citations

69
Per- and perfluoroalkyl substances alternatives, mixtures and liver function in adults: A community-based population study in China DOI Creative Commons
Jiaojiao Liu,

Xin-Xin Cui,

Ya-Wen Tan

et al.

Environment International, Journal Year: 2022, Volume and Issue: 163, P. 107179 - 107179

Published: March 21, 2022

Experimental evidence has shown that per- and polyfluoroalkyl substances (PFAS) alternatives mixtures may exert hepatotoxic effects in animals. However, epidemiological is limited. This research aimed to explore associations of PFAS the with liver function a general adult population. The study participants consisted 1,303 adults from community-based cross-sectional investigation Guangzhou, China, November 2018 August 2019. We selected 13 detection rates > 85% serum samples focused on perfluorooctane-sulfonic acid (PFOS), perfluorooctanoic (PFOA) their [6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), 8:2 Cl-PFESA, perfluorohexanoic (PFHxA)] as predictors outcome. Six biomarkers (ALB, ALT, AST, GGT, ALP, DBIL) were chosen outcomes. applied regression models restricted cubic spline correlations between single inspected combined effect by applying Bayesian kernel machine (BKMR). discovered positive among except for ALP. For example, compared 25th percentile concentration, level ALT increased 12.36% (95% CI: 7.91%, 16.98%) ln-6:2 5.59% 2.35%, 8.92%) ln-8:2 3.56% −0.39%, 7.68%) ln-PFHxA, 13.91% 8.93%, 19.13%) ln-PFOA, 14.25% 9.91%, 18.77%) ln-PFOS at 75th percentile. In addition, higher exposed was found be correlated greater odds abnormal function. Analysis BKMR also showed an adverse association mixture appeared non-interactive, which PFOS main contributor overall effect. Our findings provide alternatives, mixtures,

Language: Английский

Citations

60
Review: Hydrothermal treatment of per- and polyfluoroalkyl substances (PFAS) DOI
Jianna Li, Brian R. Pinkard, Shuzhong Wang

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 307, P. 135888 - 135888

Published: Aug. 2, 2022

Language: Английский

Citations

48
PFOS destruction in a continuous supercritical water oxidation reactor DOI Creative Commons
Jianna Li, Conrad Austin, Stuart Moore

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 451, P. 139063 - 139063

Published: Sept. 7, 2022

Language: Английский

Citations

42
Recent progress and challenges on the removal of per- and poly-fluoroalkyl substances (PFAS) from contaminated soil and water DOI
Teklit Gebregiorgis Ambaye, Mentore Vaccari, Shiv Prasad

et al.

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(39), P. 58405 - 58428

Published: June 26, 2022

Language: Английский

Citations

40
Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity DOI
Yvonne Rericha, Dunping Cao, Lisa Truong

et al.

iScience, Journal Year: 2022, Volume and Issue: 25(2), P. 103789 - 103789

Published: Jan. 17, 2022

Language: Английский

Citations

38
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies DOI
Sandra India Aldana, Meizhen Yao, Vishal Midya

et al.

Current Pollution Reports, Journal Year: 2023, Volume and Issue: 9(3), P. 510 - 568

Published: June 29, 2023

Language: Английский

Citations

33
Metabolic perturbations in pregnant rats exposed to low-dose perfluorooctanesulfonic acid: An integrated multi-omics analysis DOI Creative Commons

Guoqi Yu,

Jinguo Wang, Yongjie Liu

et al.

Environment International, Journal Year: 2023, Volume and Issue: 173, P. 107851 - 107851

Published: Feb. 26, 2023

Emerging epidemiological evidence has linked per- and polyfluoroalkyl substances (PFAS) exposure could be to the disturbance of gestational glucolipid metabolism, but toxicological mechanism is unclear, especially when at a low level. This study examined metabolic changes in pregnant rats treated with relatively dose perfluorooctanesulfonic acid (PFOS) through oral gavage during pregnancy [gestational day (GD): 1–18]. We explored molecular mechanisms underlying perturbation. Oral glucose tolerance test (OGTT) biochemical tests were performed assess homeostasis serum lipid profiles Sprague-Dawley (SD) randomly assigned starch, 0.03 0.3 mg/kg·bw·d groups. Transcriptome sequencing combined non-targeted metabolomic assays further identify differentially altered genes metabolites liver maternal rats, determine their correlation phenotypes. Results transcriptome showed that expressed PFOS related several pathways, such as peroxisome proliferator-activated receptors (PPARs) signaling, ovarian steroid synthesis, arachidonic insulin resistance, cholesterol unsaturated fatty bile secretion. The untargeted metabolomics identified 164 158 differential groups, respectively under negative ion mode Electrospray Ionization (ESI-), which enriched pathways α-linolenic glycolysis/gluconeogenesis, glycerolipid glucagon signaling pathway, glycine, serine threonine metabolism. Co-enrichment analysis indicated may disturb metabolism glycerolipid, linoleic acid, biosynthesis, threonine. key involved included down-regulated Ppp1r3c Abcd2, up-regulated Ogdhland Ppp1r3g, increased glycerol 3-phosphate lactosylceramide identified. Both them significantly associated fasting blood (FBG) Our findings provide mechanistic clues for clarifying toxicity human, susceptible population women.

Language: Английский

Citations

28
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution DOI Open Access
Arianna Dolce, Sara Della Torre

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2335 - 2335

Published: May 16, 2023

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic and represents an increasing public health issue given limited treatment options its association with several other metabolic inflammatory disorders. The epidemic, still growing prevalence NAFLD worldwide cannot be merely explained by changes in diet lifestyle that occurred last few decades, nor from their genetic epigenetic risk factors. It conceivable environmental pollutants, which act as endocrine disruptors, may contribute to spreading this pathology due ability enter food chain ingested through contaminated water. Given strict interplay between nutrients regulation hepatic metabolism reproductive functions females, pollutant-induced dysfunctions particular relevance for female liver, dampening sex differences prevalence. Dietary intake pollutants can particularly detrimental during gestation, when endocrine-disrupting chemicals interfere programming metabolism, accounting developmental origin offspring. This review summarizes cause-effect evidence increased incidence emphasizes need further studies field.

Language: Английский

Citations

27
Life cycle assessment and life cycle cost analysis of anion exchange and granular activated carbon systems for remediation of groundwater contaminated by per- and polyfluoroalkyl substances (PFASs) DOI Creative Commons
Anderson Ellis, Treavor H. Boyer, Yida Fang

et al.

Water Research, Journal Year: 2023, Volume and Issue: 243, P. 120324 - 120324

Published: July 8, 2023

Language: Английский

Citations

25