Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease? DOI Open Access
Teresa Auguet, Laia Bertran, Andrea Barrientos‐Riosalido

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(20), P. 13495 - 13495

Published: Oct. 18, 2022

Nonalcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic injury; however, mechanisms underlying its progression have not been fully elucidated. Pathophysiological studies stated that NAFLD is significantly influenced by dietary and environmental factors could participate in development through different mechanisms. Currently, “plastic pollution” one most challenging problems worldwide since several plastics potential toxic or endocrine disputing properties. Specifically, intake microplastics (MPs) nanoplastics (NPs) water diet and/or inhalation from suspended particles well established, these found human samples. Laboratory animals exposed to MPs develop inflammation, immunological responses, disruptions, alterations lipid energy metabolism, among other disorders. additives also demonstrated adverse reactions. There evidence their are “obesogens” pathogenesis modifying gut microbiota composition even worsen fibrosis. Although exposure seems clear, relationship with requires further study, prevention be a possible personalized therapeutic strategy. Adequate mitigation strategies worldwide, reducing pollution levels MPs, reduce risk NAFLD.

Language: Английский

Adverse effects and potential mechanisms of polystyrene microplastics (PS-MPs) on the blood-testis barrier DOI
Jinchen Jiang,

Zhenhao Shu,

Lianglin Qiu

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(7)

Published: June 7, 2024

Language: Английский

Citations

7
Enhancing Metabolome Annotation by Electron Impact Excitation of Ions from Organics-Molecular Networking DOI
Xinxin Wang,

Xiaoshan Sun,

Fubo Wang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(4), P. 1444 - 1453

Published: Jan. 19, 2024

Liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is widely used in untargeted metabolomics, but large-scale and high-accuracy metabolite annotation remains a challenge due to the complex nature of biological samples. Recently introduced electron impact excitation ions from organics (EIEIO) fragmentation can generate information-rich fragment ions. However, effective utilization EIEIO tandem (MS/MS) hindered by lack reference spectral databases. Molecular networking (MN) shows great promise metabolome annotation, enhancing correlation between structural similarity essential fully exploring benefits MN annotation. In this study, novel approach was proposed enhance metabolomics using MN. MS/MS spectra were acquired collision-induced dissociation (CID) modes for over 400 metabolites. The study revealed stronger structure. Moreover, network outperformed CID capturing analogues. performance LC-MS/MS evaluated. For spiked NIST SRM 1950 human plasma, coverage accuracy 72.94 74.19%, respectively. A total 2337 features successfully annotated which twice that LC-CID MS/MS. Finally, developed method applied investigate prostate cancer. 87 significantly differential metabolites annotated. This combining makes valuable contribution improving

Language: Английский

Citations

6
Co-exposure to 55 endocrine-disrupting chemicals linking diminished sperm quality: Mixture effect, and the role of seminal plasma docosapentaenoic acid DOI Creative Commons
Chang Gao, Nan Sun,

Jinying Xie

et al.

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108571 - 108571

Published: March 1, 2024

Isolated effects of single endocrine-disrupting chemicals (EDCs) on male reproductive health have been studied extensively, but their mixture effect remains unelucidated. Previous research has suggested that consuming diet enriched in omega-3 polyunsaturated fatty acids (PUFA) might be beneficial for health, whether PUFA could moderate the EDCs semen quality to explored. In this study 155 recruited from a center China, we used targeted-exposomics simultaneously measure 55 urine exposure burden. Regression analyses were restricted highly detected (≥55 %, n = 34), and those with consistently elevated risk further screened brought into models (Bisphenol A, ethyl paraben, methyl paraben [MeP], benzophenone-1 [BP1], benzophenone-3, mono(3-carboxypropyl) phthalate [MCPP]). Bayesian Kernel Machine (BKMR) quantile-based g-computation (QGC) demonstrated co-exposure top-ranked was related reduced sperm total (β −0.18, 95 % CI: −0.29 – −0.07, P 0.002) progressive motility −0.27, %CI: −0.43 −0.10, 0.002), not lower volume. BP1, MeP MCPP identified as main driver deteriorated motion parameters using model analyses. Seminal plasma acid profiling showed high status, notably docosapentaenoic (DPA, C22:5n-3) moderated association between (total motility: β 0.26, 0.01 −0.51, Pinteraction 0.047; 0.64, 0.23 1.05, 0.003). Co-exposure range is mainly associated quality, lesser extent quantity, seminal DPA status protective against effect. Our work emphasizes importance exposomic approach assess chemical exposures highlighted new possible intervention target mitigating potential adverse quality.

Language: Английский

Citations

6
Sex-Specific Effects of Polystyrene Microplastic and Lead(II) Co-Exposure on the Gut Microbiome and Fecal Metabolome in C57BL/6 Mice DOI Creative Commons
Weishou Shen, Meng Zhao,

Weichen Xu

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 189 - 189

Published: March 27, 2024

The wide spread of microplastics has fueled growing public health concern globally. Due to their porous structure and large surface area, can serve as carriers for other environmental pollutants, including heavy metals. Although the toxic effects or metals have been reported previously, investigations into sex-differential combined exposure are lacking. In present study, polystyrene lead(II) co-exposure on gut microbiome, intestinal permeability, fecal metabolome were examined in both male female mice. Combined increased permeability Sex-specific responses found bacteria, fungi, microbial metabolic pathways, genes encoding antibiotic resistance virulence factors, well profiles. particular, Shannon Simpson indices bacteria reduced by only A total 34 13 metabolites altered group mice, respectively, among which three shared sexes. These sex-specific need be taken consideration when investigating microbiota.

Language: Английский

Citations

6
Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease? DOI Open Access
Teresa Auguet, Laia Bertran, Andrea Barrientos‐Riosalido

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(20), P. 13495 - 13495

Published: Oct. 18, 2022

Nonalcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic injury; however, mechanisms underlying its progression have not been fully elucidated. Pathophysiological studies stated that NAFLD is significantly influenced by dietary and environmental factors could participate in development through different mechanisms. Currently, “plastic pollution” one most challenging problems worldwide since several plastics potential toxic or endocrine disputing properties. Specifically, intake microplastics (MPs) nanoplastics (NPs) water diet and/or inhalation from suspended particles well established, these found human samples. Laboratory animals exposed to MPs develop inflammation, immunological responses, disruptions, alterations lipid energy metabolism, among other disorders. additives also demonstrated adverse reactions. There evidence their are “obesogens” pathogenesis modifying gut microbiota composition even worsen fibrosis. Although exposure seems clear, relationship with requires further study, prevention be a possible personalized therapeutic strategy. Adequate mitigation strategies worldwide, reducing pollution levels MPs, reduce risk NAFLD.

Language: Английский

Citations

28