The potential impact of nano- and microplastics on human health: Understanding human health risks.

Environmental Research, Journal Year: 2024, Volume and Issue: 251, P. 118535 - 118535

Published: March 7, 2024

Plastics are used all over the world. Unfortunately, due to limited biodegradation, plastics cause a significant level of environmental pollution. The smallest recognized date termed nanoplastics (1 nm [nm] up 1 μm [μm]) and microplastics μm–5 mm). These nano- can enter human body through respiratory system via inhalation, digestive tract consumption contaminated food water, or penetration skin cosmetics clothes contact. Bioaccumulation in potentially lead range health issues, including disorders like lung cancer, asthma hypersensitivity pneumonitis, neurological symptoms such as fatigue dizziness, inflammatory bowel disease even disturbances gut microbiota. Most studies have confirmed that induce apoptosis cells genotoxic cytotoxic effects. Understanding cellular molecular mechanisms plastics' actions may help extrapolate risks humans. article provides comprehensive review articles databases regarding impact on health. included retrospective case reports people exposed microplastics. This research highlights need for further fully understand extent

Language: Английский

---

Food chain microplastics contamination and impact on human health: a review

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(4), P. 1889 - 1927

Published: April 9, 2024

Language: Английский

---

Polystyrene Microplastics Induce Oxidative Stress in Mouse Hepatocytes in Relation to Their Size

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7382 - 7382

Published: April 17, 2023

Microplastics have become a new type of environmental pollutant that can accumulate in various tissues and organs the body cause chronic damage. In this study, two different size polystyrene microplastics (PS-MPs, 5 μm 0.5 μm) exposure models were established mice to investigate effects PS-MPs with particle sizes on oxidative stress liver. The results showed caused decrease weight liver-to-body weight. hematoxylin eosin staining transmission electron microscopy led disorganized cellular structure liver tissue, nuclear crinkling, mitochondrial vacuolation. extent damage PS-MP group was more extensive when compared other group. evaluation oxidative-stress-related indicators exacerbated hepatocytes, especially expression proteins sirtuin 3(SIRT3) superoxide dismutase (SOD2) significantly reduced, reduction pronounced conclusion, mouse hepatocytes severe

Language: Английский

---

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2335 - 2335

Published: May 16, 2023

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic and represents an increasing public health issue given limited treatment options its association with several other metabolic inflammatory disorders. The epidemic, still growing prevalence NAFLD worldwide cannot be merely explained by changes in diet lifestyle that occurred last few decades, nor from their genetic epigenetic risk factors. It conceivable environmental pollutants, which act as endocrine disruptors, may contribute to spreading this pathology due ability enter food chain ingested through contaminated water. Given strict interplay between nutrients regulation hepatic metabolism reproductive functions females, pollutant-induced dysfunctions particular relevance for female liver, dampening sex differences prevalence. Dietary intake pollutants can particularly detrimental during gestation, when endocrine-disrupting chemicals interfere programming metabolism, accounting developmental origin offspring. This review summarizes cause-effect evidence increased incidence emphasizes need further studies field.

Language: Английский

---

Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

---

Microplastics levels in cultured or harvested mollusks non-depurated and commercially depurated at different times

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 212, P. 117568 - 117568

Published: Jan. 16, 2025

Language: Английский

---

Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics

American Journal of Industrial Medicine, Journal Year: 2023, Volume and Issue: 66(12), P. 1033 - 1047

Published: Sept. 24, 2023

Abstract Background Plastic debris pervades our environment. Some breaks down into microplastics (MPs) that can enter and distribute in living organisms causing effects multiple target organs. MPs have been demonstrated to harm animals through environmental exposure. Laboratory animal studies are still insufficient evaluate human impact. And while found tissues, the health at exposure levels unclear. Aim We reviewed summarized existing evidence on from occupational MPs. Additionally, diverse documented for workers were organized by MP type associated co‐contaminants. Evidence of unique polyvinyl chloride (PVC) liver was then highlighted. Methods conducted two stepwise online literature reviews publications focused risks with exposures. This information supplemented findings studies. Results Our analysis 34 published half involving PVC other a variety compare. Liver following reported workers. While causes toxicity increases risk cancers, including angiosarcomas hepatocellular carcinomas, carcinogenic work‐related MPs, such as polystyrene polyethylene, not well understood. Conclusion The data supporting strongest Overall, than is lacking. worker here be useful assisting clinicians evaluating histories designing future cell, animal, population exposure‐effect research

Language: Английский

---

Microplastics and associated chemicals in drinking water: A review of their occurrence and human health implications

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169594 - 169594

Published: Dec. 27, 2023

Language: Английский

---

Combined exposure to polyvinyl chloride and polystyrene microplastics induces liver injury and perturbs gut microbial and serum metabolic homeostasis in mice

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 267, P. 115637 - 115637

Published: Nov. 1, 2023

A variety of microplastics (MPs) have become ubiquitous environmental pollutants, leading to inevitable human contact and health impacts. Most previous research has explored the toxic effects a single type MPs exposure. However, co-exposure both common types MPs, polyvinyl chloride (PVC) polystyrene (PS) on mammals not been explored. Here, adult mice were exposed PS-PVC (1.0 µm PS 2.0 PVC at concentration 0.5 mg/day) for 60 days. The results showed that co-exposure-induced hepatotoxicity was evidenced by liver histopathological changes, release inflammatory cytokines, activation oxidative stress. Moreover, intestinal mucosal barrier damaged after treatment. 16S rRNA gene sequencing reported there marked shift in gut microbial structure accompanied decreased relative abundances probiotics, such as Clostridium, Lachnospiraceae_UCG-006, Desulfovibrio, Clostridiales_unclassified Ruminococcaceae_unclassified increased conditional pathogen abundances, Erysipelatoclostridium. Furthermore, triglyceride (TG) total cholesterol (TCH) expression levels serum co-exposure. Serum metabolomics analysis 717 differential metabolites found positive- negative-ion modes, including 476 up-regulated 241 down-regulated, mainly enriched butyrate metabolism, thiamine phenylacetate metabolism. In addition, remarked changes microbiota metabolic profiles closely related hepatic injuries These provided new insights into through gut-liver axis risks should be paid more attention humans.

Language: Английский

---

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Liver International, Journal Year: 2024, Volume and Issue: 44(5), P. 1093 - 1105

Published: Feb. 26, 2024

Abstract Plastics, while providing modern conveniences, have become an inescapable source of global concern due to their role in environmental pollution. Particularly, the focus on bisphenol A (BPA) reveals its biohazardous nature and association with liver issues, specifically steatosis. However, research indicates that BPA is just one facet problem, as other analogues, microplastics, nanoplastics additional plastic derivatives also pose potential risks. Notably, implicated every stage non‐alcoholic fatty disease (NAFLD) onset progression, surpassing hepatitis B virus a primary cause chronic worldwide. As contamination tops contaminants list, urgent action needed assess causative factors mitigate impact. This review delves into molecular disruptions linking pollutant exposure diseases, emphasizing broader connection between plastics rising prevalence NAFLD.

Language: Английский

---