The untold story of PFAS alternatives: Insights into the occurrence, ecotoxicological impacts, and removal strategies in the aquatic environment

Water Research, Journal Year: 2023, Volume and Issue: 250, P. 121044 - 121044

Published: Dec. 23, 2023

Language: Английский

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Insights into the circadian rhythm alterations of the novel PFOS substitutes F-53B and OBS on adult zebrafish

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 448, P. 130959 - 130959

Published: Feb. 8, 2023

Language: Английский

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Interactive effects of polystyrene nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonates on the histomorphology, oxidative stress and gut microbiota in Hainan Medaka (Oryzias curvinotus)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 880, P. 163307 - 163307

Published: April 6, 2023

Language: Английский

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Hepatic injury and ileitis associated with gut microbiota dysbiosis in mice upon F–53B exposure

Environmental Research, Journal Year: 2024, Volume and Issue: 248, P. 118305 - 118305

Published: Feb. 1, 2024

Language: Английский

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Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(11), P. 4904 - 4913

Published: March 4, 2024

The Yangtze River fishery resources have declined strongly over the past few decades. One suspected reason for decline in productivity, including silver carp (Hypophthalmichthys molitrix), has been linked to organophosphate esters (OPEs) contaminant exposure. In this study, adverse effect of OPEs on lipid metabolism captured from was examined, and our results indicated that muscle concentrations were positively associated with serum cholesterol total levels. vivo laboratory revealed exposure environmental significantly increased triglyceride, cholesterol, Lipidome analysis further confirmed dysfunction induced by OPEs, glycerophospholipids sphingolipids most affected lipids. Hepatic transcriptomic found caused significant alterations transcription genes involved metabolism. Pathways homeostasis, peroxisome proliferator-activated receptor (PPAR) signal pathway, metabolism, fatty acid biosynthesis, steroid changed. Furthermore, affinities different, but 11 tested could bind PPARγ, suggesting disrupt interacting PPARγ. Overall, study highlighted harmful effects wild fish provided mechanistic insights into OPE-induced metabolic disorders.

Language: Английский

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Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health?

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108582 - 108582

Published: March 16, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic chemicals, encompassing compounds like perfluorooctane sulfonate (PFOS), which have widespread applications across various industries, including food packaging firefighting. In recent years, China has increasingly employed 6:2 Cl-PFESA as an alternative to PFOS. Although the association between PFAS exposure hepatocellular carcinoma (HCC) been demonstrated, underlying mechanisms that promote HCC proliferation uncleared. Therefore, we aimed investigate effects differences of PFOS on through in vivo vitro tumor models. Our results reveal both significantly contribute vivo. Exposure led reduced population doubling times, enlarged cell colony sizes, enhanced DNA synthesis efficiency, a higher proportion cells undergoing mitosis. Furthermore, Cl-PFES) shown activate PI3K/AKT/mTOR signaling pathway inhibit necroptosis. This action consequently enhances cells. phenotypic assay findings suggest tumorigenic potential surpasses PFOS; subcutaneous model using nude mice, mean weight for Cl-PFESA-treated cohort was 2.33 times observed (p < 0.01). Despite being considered safer substitute PFOS, pronounced this chemical growth warrant thorough assessment hepatotoxicity risks linked its usage.

Language: Английский

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Bone cell differentiation and mineralization in wild-type and osteogenesis imperfecta zebrafish are compromised by per- and poly-fluoroalkyl substances (PFAS)

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Perfluorinated compounds (PFAS) are well recognized toxic pollutants for humans, but if their effect is equally harmful healthy and fragile people unknown. Addressing this question represents a need ensuring global health wellbeing to all individuals in world facing the progressive increase of aging related diseases. This study aimed evaluate impact perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) perfluorohexanoic (PFHxA) exposure on development skeletal phenotype using osteogenesis imperfecta (OI) zebrafish model Chihuahua (Chi/+), carrying dominant glycine substitution α1 chain collagen I wild-type (WT) littermates. To purpose Chi/+ WT expressing green fluorescent protein under early osteoblast marker osterix were exposed from 1 6 days post fertilization 0.36, 1.5 3.0 mg/L PFOS, 0.005 0.5 PFOA 0.01, 0.48 16.0 PFHxA, investigated. Morphometric measurements, confocal microscopy evaluation operculum area delimited by preosteoblasts mineral deposition analysis following alizarin red staining employed. PFOS highest concentration PFHxA significantly impaired standard length both genotypes. Osteoblast differentiation was compromised only Chi/+. Limited reduced mineralization also observed. No detected after exposure. Apoptosis activated PFOA, specifically mutant osteoblasts. Interestingly, an altered lipid distribution fish revealed pollutants. In conclusion, our data demonstrate that PFAS impair mainly compromising cell whereas alter hepatic genotypes with more severe preosteoblast survival. These results represent first warning sign negative presence genetically determined fragility.

Language: Английский

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Investigation of the Mechanisms of Liver Injury Induced by Emamectin Benzoate Exposure at Environmental Concentrations in Zebrafish: A Multi-Omics Approach to Explore the Role of the Gut-Liver Axis

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138008 - 138008

Published: March 1, 2025

Language: Английский

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Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) as a novel surrogate for perfluorooctanesulfonate (PFOS) has been extensively utilized in industrial manufacturing and daily life. However, studies on OBS-induced environmental health risks of obstructive biosynthesis are currently limited, particularly the risk thyroid diseases. Following construction vivo (mouse) vitro (normal human primary thyrocytes) models subchronic low-dose OBS exposure, we explored thyroid-disrupting effects through multiomics approaches experimental validations. Our results showed that exposure to low doses led hypothyroidism mice, presenting with reduced number functional abnormalities thyrocytes. Further assays confirmed disulfidptosis, newly discovered form programmed cell death, Meanwhile, remarkably suppressed hormone synthesis pathways mouse The charted multiomic landscape mammals revealed toxicity endocrine-disrupting properties OBS, suggesting it is not safe alternative PFOS.

Language: Английский

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Sorption and mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFASs) on different particle size fractions of marine sediments

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121643 - 121643

Published: April 1, 2025

Language: Английский

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