Assessing the contribution of the chemical exposome to neurodegenerative disease

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(5), P. 812 - 821

Published: April 29, 2024

Language: Английский

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Emerging technologies for the removal of pesticides from contaminated soils and their reuse in agriculture

Chemosphere, Journal Year: 2024, Volume and Issue: 362, P. 142433 - 142433

Published: May 29, 2024

Language: Английский

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Pesticide residues with hazard classifications relevant to non-target species including humans are omnipresent in the environment and farmer residences

Environment International, Journal Year: 2023, Volume and Issue: 181, P. 108280 - 108280

Published: Oct. 30, 2023

Intensive and widespread use of pesticides raises serious environmental human health concerns. The presence levels 209 pesticide residues (active substances transformation products) in 625 samples (201 soil, 193 crop, 20 outdoor air, 115 indoor dust, 58 surface water, 38 sediment samples) have been studied. were collected during the 2021 growing season, across 10 study sites, covering main European crops, conventional organic farming systems. We profiled found different matrices using existing hazard classifications towards non-target organisms humans. Combining monitoring data information, we developed an indicator for prioritization pesticides, which can support policy decisions sustainable transitions. Eighty-six percent had at least one residue above respective limit detection. One hundred 112 99 sediments, 78 76 197 dust. number, levels, profile varied between Our results show that non-approved compounds still represent a significant part cocktails should be accounted programs risk assessments. profiles analysis confirms dominance low-moderate underscores high some approved recurring "no available" situations. Overall, our idea assessed mixture context, taking environmentally relevant mixtures into consideration. uncovered uncertainties gaps addressed, as well implications EU approval status level. newly introduced help identify research priority areas, act reference targeted scenarios set forth Farm to Fork reduction goals.

Language: Английский

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Assessing human exposure to pesticides and mycotoxins: optimization and validation of a method for multianalyte determination in urine samples

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(8), P. 1935 - 1949

Published: Feb. 7, 2024

Humans are exposed to an increasing number of contaminants, with diet being one the most important exposure routes. In this framework, human biomonitoring is considered gold standard for evaluating chemicals. Pesticides and mycotoxins chemicals special concern due their health implications. They constitute predominant border rejection notifications food feed in Europe USA. However, current studies focused on a limited compounds do not evaluate pesticides together. study, analytical method has been developed determination 30 23 urine samples. A salting-out liquid-liquid extraction (SALLE) procedure was optimized achieving recoveries between 70 120% almost all limits as lower when QuEChERS applied. The were then determined by liquid chromatography coupled triple quadrupole mass spectrometry. Different chromatographic conditions columns tested, selecting Hypersild aQ column best option. Finally, applied analysis 45 samples, which organophosphate pyrethroid (detection rates (DR) 82% 42%, respectively) ochratoxin deoxynivalenol (DR 51% 33%, detected compounds. proposed involves simultaneous diverse set mycotoxins, including relevant metabolites, urine. It serves essential tool presence highly prevalent contaminants modern society.

Language: Английский

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Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU

International Journal of Hygiene and Environmental Health, Journal Year: 2023, Volume and Issue: 249, P. 114135 - 114135

Published: Feb. 7, 2023

Unintentional chemical mixtures that are present in the environment of societal concern as (environmental) chemicals contained therein, either singly or combination, may possess properties hazardous (toxic) for human health. The current regulatory practice, however, is still largely based on evaluating single substances one-by-one. Over years various research efforts have delivered tools and approaches risk assessment mixtures, but many these were not considered sufficiently mature implementation. This (partly) due to mixture (MRA) being very complex because large number environment. A key element information actual exposures population interest. To date, personal (internal) absent, severely limiting MRA. use biomonitoring data improve this situation. Therefore, we investigated within European Human Biomonitoring Initiative (HBM4EU) assess combined Based insights lessons learnt context HBM4EU project, conclusions well recommendations policy development regarding further drafted. These relate both exposure adverse health effects humans. discussed with stakeholders a workshop held October 2021. There was considerable support agreement spirit, scope intention draft recommendations. Here describe through project final Overall, results demonstrated potential an instrument obtain insight into real-life exposed to. Also, public concern. In majority cases, it possible identify drivers, i.e. contribute more strongly than others risk. novel co-occurrence patterns clusters co-occurring chemicals; regulated independently under different legislative frameworks. Moreover, expertise can science-based derivation Mixture Assessment Factor gauge impacts population's chemicals. While expansion needed aspects activities carried out HBM4EU, application available methodologies should already be implemented degree possible.

Language: Английский

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Evaluating LC-HRMS metabolomics data processing software using FAIR principles for research software

Metabolomics, Journal Year: 2023, Volume and Issue: 19(2)

Published: Feb. 6, 2023

Language: Английский

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EAACI guidelines on environmental science for allergy and asthma: The impact of short‐term exposure to outdoor air pollutants on asthma‐related outcomes and recommendations for mitigation measures

Allergy, Journal Year: 2024, Volume and Issue: 79(7), P. 1656 - 1686

Published: April 2, 2024

Abstract The EAACI Guidelines on the impact of short‐term exposure to outdoor pollutants asthma‐related outcomes provide recommendations for prevention, patient care and mitigation in a framework supporting rational decisions healthcare professionals patients individualize improve asthma management policymakers regulators as an evidence‐informed reference help setting legally binding standards goals air quality at international, national local levels. Guideline was developed using GRADE approach evaluated referenced current Air Quality World Health Organization single or mixed pesticides. Short‐term all increases risk adverse outcomes, especially hospital admissions emergency department visits (moderate certainty evidence specific lag days). There is limited traffic‐related pollution pesticides well interventions reduce emissions. Due evidence, conditional were formulated reducing pollution. Asthma counselled by guidelines can but global measures clean are needed achieve significant impact.

Language: Английский

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Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach

International Journal of Hygiene and Environmental Health, Journal Year: 2022, Volume and Issue: 248, P. 114105 - 114105

Published: Dec. 21, 2022

Humans are exposed to a mixture of pesticides through diet as well the environment. We conducted suspect-screening based study describe probability (concomitant) exposure set pesticide profiles in five European countries (Latvia, Hungary, Czech Republic, Spain and Netherlands). explored whether living an agricultural area (compared peri-urban area), being child adult), season which urine sample was collected had impact on detection (-metabolites). In total 2088 samples were from 1050 participants (525 parent-child pairs) analyzed harmonized suspect screening by different laboratories. Fourty biomarkers (either metabolites or parent such) relating 29 identified at high levels confidence across all sites. Most frequently detected related acetamiprid chlorpropham. Other with rates least four boscalid, fludioxonil, pirimiphos-methyl, pyrimethanil, clothianidin, fluazifop propamocarb. 84% two detected. The median number 3, maximum 13 single sample. most co-occurring substances chlorpropham (in 62 samples), tebuconazole (30 samples). Some variation (-metabolites) observed sampling, though no consistent patterns observed. did observe differences (metabolite) among children compared adults, suggesting and/or elimination between adults children. This survey demonstrates feasibility conducting pan-European collection, combined provide insight presence mixtures population, including areas. Future improvements could come improved (harmonized) quantification levels.

Language: Английский

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Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108585 - 108585

Published: March 17, 2024

The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, prevent adverse impacts environmental health associated with hazardous chemicals. Surveillance of chemicals known, emerging, or potential future concern, entering environment-food-human continuum needed document reality risks posed by ecosystem from a one perspective, feed into early warning systems support public policies for exposure mitigation provisions safe sustainable design strategies. use less-conventional sampling strategies integration full-scan, high-resolution mass spectrometry effect-directed analysis in monitoring programmes have enhance screening identification wider range emerging concern. Here, we outline key needs recommendations identified within European Partnership Assessment Risks Chemicals (PARC) project leveraging these innovative methodologies development next-generation assessment.

Language: Английский

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Assessing background contamination of sample tubes used in human biomonitoring by non-targeted liquid chromatography–high resolution mass spectrometry

Environment International, Journal Year: 2024, Volume and Issue: 183, P. 108426 - 108426

Published: Jan. 1, 2024

Controlling and minimising background contamination is crucial for maintaining a high quality of samples in human biomonitoring targeting organic chemicals. We assessed the three previous types one newly introduced medical-grade type sample tubes used storing body fluids at German Environmental Specimen Bank. Aqueous extracts from these were analysed by non-targeted liquid chromatography-high resolution mass spectrometry (LC-HRMS) before after dedicated cleaning procedure. After peak detection using MZmine, Bayesian hypothesis testing was to group peaks into those originating either instrumental laboratory contamination, or actual tube contaminants, based on if their height reduced, increased not affected For all four 80-90% 2475 (1549 positive 926 negative mode) assigned laboratory/instrumental background, which we have consider as potential contaminants. Among results suggest considerable difference contaminant inventory absolute level among different types. The procedure did affect largest fraction (50-70%). medical grade tubes, removal contaminants strongest compared but cases small intensity cleaning, probably due release oligomers additives. identified mainly semi-volatile polymer additives such phthalates phosphate esters. A few compounds could be solely tube-specific N,N-dibutylformamide several constituents oligomeric light stabiliser Tinuvin-622. Cleaning use an effective way standardise minimises therefore increases therewith analytical results.

Language: Английский

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