Subchronic Exposure to Polystyrene Microplastic Differently Affects Redox Balance in the Anterior and Posterior Intestine of Sparus aurata DOI Creative Commons
Filomena Del Piano, Adriano Lama,

Anna Monnolo

et al.

Animals, Journal Year: 2023, Volume and Issue: 13(4), P. 606 - 606

Published: Feb. 9, 2023

Microplastics (MPs) are pollutants widely distributed in aquatic ecosystems. MPs introduced mainly by ingestion acting locally or organs far from the gastroenteric tract. MPs-induced health consequences for fish species still need to be fully understood. We aimed investigate effects of subchronic oral exposure polystyrene microplastics (PS-MPs) (1-20 μm) gilthead seabreams (Sparus aurata) used as experimental model. studied detrimental impact PS-MPs (25 and 250 mg/kg b.w./day) on redox balance antioxidant status intestine using histological analysis molecular techniques. The research goal was examine anterior (AI) posterior (PI) tracts, characterized morphological functional differences. caused an increase reactive oxygen nitrosylated proteins both well augmented malondialdehyde production PI. also differently affected gene expression enzymes (i.e., superoxide dismutase, catalase, glutathione reductase). Moreover, increased up-regulation protective heat shock (HSPs) hsp70 hsp90) observed Our findings demonstrate that responsible oxidative/nitrosative stress alterations detoxifying defense system responses with differences AI PI seabreams.

Language: Английский

Nanoplastics induces oxidative stress and triggers lysosome-associated immune-defensive cell death in the earthworm Eisenia fetida DOI Creative Commons
Yanfei Zhou, Gang He, Hao Jiang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 174, P. 107899 - 107899

Published: March 27, 2023

Nanoplastics (NPs) are increasingly perceived as an emerging threat to terrestrial environments, but the adverse impacts of NPs on soil fauna and mechanisms behind these negative outcomes remain elusive. Here, a risk assessment was conducted model organism (earthworm) from tissue cell. Using palladium-doped polystyrene NPs, we quantitatively measured nanoplastic accumulation in earthworm investigated its toxic effects by combining physiological with RNA-Seq transcriptomic analyses. After 42-day exposure, accumulated up 15.9 143.3 mg kg-1 for low (0.3 kg-1) high (3 dose groups, respectively. retention led decrease antioxidant enzyme activity reactive oxygen species (O2- H2O2), which reduced growth rate 21.3 %-50.8 % caused pathological abnormalities. These were enhanced positively charged NPs. Furthermore, observed that irrespective surface charge, after 2 h gradually internalized coelomocytes (∼0.12 μg per cell) mainly amassed at lysosomes. Those agglomerations stimulated lysosomal membranes lose stability even rupture, resulting impeded autophagy process cellular clearance, eventually coelomocyte death. In comparison negatively nanoplastics, exerted 83 higher cytotoxicity. Our findings provide better understanding how posed harmful have important implications evaluating ecological

Language: Английский

Citations

38
Biological uptake, distribution and toxicity of micro(nano)plastics in the aquatic biota: A special emphasis on size-dependent impacts DOI Open Access
Wanjing Liu,

Hongping Liao,

Maochun Wei

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 170, P. 117477 - 117477

Published: Dec. 6, 2023

Language: Английский

Citations

38
Global hotspots and trends in interactions of microplastics and heavy metals: a bibliometric analysis and literature review DOI

Kehan Li,

Fayuan Wang

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(41), P. 93309 - 93322

Published: Aug. 5, 2023

Language: Английский

Citations

23
Combined toxic effects of polystyrene microplastics and 3,6-dibromocarbazole on zebrafish (Danio rerio) embryos DOI
Jie Zhang,

Yao Bai,

Haoran Meng

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 913, P. 169787 - 169787

Published: Jan. 4, 2024

Language: Английский

Citations

14
Mitochondria as a Target of Micro- and Nanoplastic Toxicity DOI Creative Commons
Fulya Dal, Müfide Aydoğan Ahbab

Cambridge Prisms Plastics, Journal Year: 2024, Volume and Issue: 2

Published: Jan. 1, 2024

Abstract Mitochondria are unique organelles to perform critical functions such as energy production, lipid oxidation, calcium homeostasis, and steroid hormone synthesis in eukaryotic cells. The proper functioning of mitochondria is crucial for cellular survival, bioenergetics. Mitochondrial structure function maintained by the mitochondrial quality control system, which consists processes biogenesis, dynamics (fusion/fission), mitophagy, unfolded protein response UPR MT . dysfunction and/or damage associated with initiation progression several human diseases, including neurodegenerative, cardiovascular, age-related diabetes, cancer. Environmental stress contaminants may exacerbate sensitivity causes dysfunction. There growing evidence about impact nanoplastics (NPs) microplastics (MPs) on health function. MPs/NPs were reported trigger oxidative reactive oxygen species eventually change membrane potential. can cross through biological barriers body be internalized cells, potentially altering dynamics, bioenergetics, signaling pathways, thus impacting metabolism This review states effects homeostasis well apoptosis discussed.

Language: Английский

Citations

12
Effects of microplastics on the kidneys: a narrative review DOI
Rodrigo Bueno de Oliveira, Lauter Eston Pelepenko,

Daniela A. Masaro

et al.

Kidney International, Journal Year: 2024, Volume and Issue: 106(3), P. 400 - 407

Published: June 18, 2024

Language: Английский

Citations

11
Mechanistic insight into the intensification of arsenic toxicity to rice (Oryza sativa L.) by nanoplastic: Phytohormone and glutathione metabolism modulation DOI
Yi Jiang, Xiaofei Chen, Xuesong Cao

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 134086 - 134086

Published: March 20, 2024

Language: Английский

Citations

10
Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis DOI

Gaolong Zhong,

Baoxin Qiao,

Ying He

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 201, P. 105904 - 105904

Published: April 10, 2024

Language: Английский

Citations

9
Investigating Parkinson’s disease risk across farming activities using data mining and large-scale administrative health data DOI Creative Commons
Pascal Petit, François Berger, Vincent Bonneterre

et al.

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 8, 2025

Abstract The risk of Parkinson’s disease (PD) associated with farming has received considerable attention, in particular for pesticide exposure. However, data on PD specific activities is lacking. We aimed to explore whether exhibited a higher than others among the entire French farm manager (FM) population. A secondary analysis real-world administrative insurance claim and electronic health/medical records (TRACTOR project) was conducted estimate 26 using mining. cases were identified through chronic declarations antiparkinsonian drug claims. There 8845 1,088,561 FMs. highest-risk group included FMs engaged pig farming, cattle truck fruit arboriculture, crop mean hazard ratios (HRs) ranging from 1.22 1.67. lowest-risk all involving horses small animals, as well gardening, landscaping reforestation companies (mean HRs: 0.48–0.81). Our findings represent preliminary work that suggests potential involvement occupational factors related onset development. Future research focusing farmers high-risk will allow uncover by better characterizing exposome, which could improve surveillance farmers.

Language: Английский

Citations

1
Ecotoxicity of emerging contaminants in the reproductive organ of marine mussels Mytilus galloprovincialis DOI Creative Commons
Joanna M. Gonçalves, Maria João Bebianno

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 881, P. 163486 - 163486

Published: April 15, 2023

Contaminants of emerging concern (CECs) present a new threat to the marine environment, and it is vital understand interactions possible toxicity CEC mixtures once they reach ocean. CECs-such as metal nanoparticles, nanoplastics, pharmaceuticals-are groups contaminants some which have been individually evaluated, though their are still not fully understood. To ensure healthy prosperous future generation, successful reproduction key: however, if hindered, population dynamics may be at danger leading negative impact on biodiversity. This study aimed effects silver (20 nm nAg, 10 μg/L), polystyrene nanoparticles (50 nPS, 5-fluorouracil (5FU, ng/L) mixture (10 μg/L nPS + nAg +10 ng/L 5FU) in gonads Mytilus galloprovincialis. A multibiomarker approach, namely antioxidant defence system (ADS; superoxide dismutase, catalase, glutathione peroxidases, - S transferases activities), oxidative damage (OD; lipid peroxidation) were analysed mussels. All exposure treatments after 3 days led an increase enzymatic activity, followed by inhibition 14 21 days. Thus, ADS was overwhelmed due generation ROS, resulting OD, except for exposed The OD Mix mussels increased exponentially 57-fold. When interact, potentially more hazardous than individual components, posing major species. synergistic antagonistic interactions, model applied, observed evaluated biomarkers all time-points, apart from interaction day relative LPO. Results indicate that Mix-exposed mussel mainly 5FU but nPS.

Language: Английский

Citations

16