Bisphenol analogues induce thyroid dysfunction via the disruption of the thyroid hormone synthesis pathway

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 900, P. 165711 - 165711

Published: July 23, 2023

Language: Английский

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Endocrine-disrupting chemicals and male reproductive health

Fertility and Sterility, Journal Year: 2023, Volume and Issue: 120(6), P. 1138 - 1149

Published: Oct. 11, 2023

Language: Английский

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Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank

Environment International, Journal Year: 2024, Volume and Issue: 195, P. 109190 - 109190

Published: Dec. 12, 2024

The German Environmental Specimen Bank (ESB) annually archives 24-h urine samples since the early 1980s. In this study, we analyzed 420 of these from years 2014 to 2022 for metabolites 18 phthalates and two substitutes. We merged new data with previous measurement campaigns a combined dataset 1825 covering 35-year period 1988 investigate time trends, calculate daily intakes perform an anti-androgenic mixture risk assessment. With extended set 41 biomarkers, are now able monitor exposure all EU-labelled reprotoxic phthalates. Most phthalate exposures continued decrease first measurements in 80s, biggest drops DnBP (96.6 %) DEHP (90.9 %). DiNP DiDP, seen on rise earlier campaigns, declined. Exposures newly included, were generally negligible. Regarding risk, 5 % highly exposed still exceeded Hazard Index (HI) 1 2009. current campaign only three individuals (0.7 HI (with exceedances driven by DnBP).In 2022, 20 had > 0.2, which propose as benchmark interpreting considering concurrent other anti-androgens. Exposure substitutes DINCH DEHTP continues increase, exceeding those 2018. Compared United States (US) National Health Nutrition Examination Survey (NHANES) seem align, except up ten times higher levels US. Human biomonitoring (HBM) is ideal tool capture actual per individual, integrating external sources pathways, thus will continue use HBM assessment (anti-androgenic) chemicals.

Language: Английский

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Organophosphate Ester Flame Retardants and Plasticizers in Relation to Fetal Growth in the LIFECODES Fetal Growth Study

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(7)

Published: July 1, 2024

Organophosphate esters (OPEs), used ubiquitously as flame retardants and plasticizers in consumer products, are suspected of having developmental toxicity.

Language: Английский

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Consumer Product Chemical Mixtures and Oxylipin-Mediated Inflammation and Oxidative Stress during Early Pregnancy: Findings from a Large US Pregnancy Cohort

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Consumer product chemicals pose an environmental risk to public health. Exposure during pregnancy consumer chemicals, particularly phthalates and phenols, may increase the susceptibility disorders by dysregulating inflammation oxidative stress. However, existing studies rely on downstream nonmodifiable markers of these processes. Oxylipins are oxidized lipids that act as key upstream drivers Importantly, oxylipins responsive therapeutic interventions thus potentially modifiable. Using recent advances in lipidomics statistical approaches address both individual chemical biomarkers their mixtures, we determined associations between early exposure a large prospective cohort. Overall, our results revealed among produced across several biosynthetic pathways, suggesting pattern indicative dysregulated elevated levels Phthalate metabolites were primary associations, for low molecular weight phthalates, often used personal care products. found similar biomarker phthalate replacement is increasingly Our study provides observational evidence specific physiological pathways be including legacy replacements.

Language: Английский

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Exposure to phthalates and replacements during pregnancy in association with gestational blood pressure and hypertensive disorders of pregnancy

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121739 - 121739

Published: April 1, 2025

Language: Английский

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Environmental phenol exposures in 6- to 12-week-old infants: the Infant Feeding and Early Development (IFED) Study

Environmental Research, Journal Year: 2024, Volume and Issue: 252, P. 119075 - 119075

Published: May 6, 2024

Language: Английский

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Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109392 - 109392

Published: March 1, 2025

Language: Английский

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Incorporating machine learning and statistical methods to address maternal healthcare disparities in US: A systematic review

International Journal of Medical Informatics, Journal Year: 2025, Volume and Issue: unknown, P. 105918 - 105918

Published: April 1, 2025

Language: Английский

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Predictors of upstream inflammation and oxidative stress pathways during early pregnancy

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 213, P. 222 - 232

Published: Jan. 21, 2024

Inflammation and oxidative stress are critical to pregnancy, but most human study has focused on downstream, non-causal indicators. Oxylipins lipid mediators of inflammation that act through many biological pathways. Our aim was characterize predictors circulating oxylipin concentrations based maternal characteristics.

Language: Английский

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