Environmental Research,
Journal Year:
2023,
Volume and Issue:
242, P. 117743 - 117743
Published: Nov. 25, 2023
Per-
and
polyfluoroalkyl
substances
(PFAS)
constitute
a
heterogeneous
group
of
synthetic
compounds
widely
used
in
industrial
applications.
The
estimation
PFAS
half-life
(t1/2)
is
essential
to
quantify
their
persistence,
toxicity
mechanism
action
humans.
purpose
this
review
summarize
the
evidence
on
half-lives
humans
from
available
literature,
investigate
limitations
uncertainties
characterizing
estimation.
search
was
conducted
PubMed,
Scopus,
Embase
databases
up
July
03,
2023
aimed
at
identifying
all
papers
that
estimated
human
populations.
We
excluded
studies
temporal
trends
or
providing
estimates
based
solely
renal
clearance.
As
persistent
ongoing
exposures
can
influence
estimation,
we
decided
include
only
were
after
main
source
exposure
had
ceased.
A
random-effects
meta-analysis
reported
perfluorooctanoic
acid
(PFOA),
perfluorooctane
sulfonic
(PFOS)
perfluorohexanesulfonic
(PFHxS)
Risk
bias
evaluated
using
OHAT
tool.
total
13
articles
included
review,
with
5
exposed
general
populations
8
workers;
mean
ranged
1.48
5.1
years
for
PFOA,
3.4
5.7
PFOS,
2.84
8.5
PFHxS.
High
heterogeneity
among
observed;
potential
reasons
variability
investigated
populations,
discrepancies
considering
exposures,
isomeric
compositions,
accounting
background
exposure,
time
since
stopped
methods
Despite
efforts
made
better
understand
toxicokinetics,
further
are
needed
identify
important
characteristics
these
chemicals.
Biomonitoring
should
focus
unaccounted
sources
individual
potentially
determining
half-life,
ensure
accurate
estimates.
Pollutants,
Journal Year:
2024,
Volume and Issue:
4(1), P. 136 - 152
Published: March 6, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
belong
to
a
group
of
synthetic
compounds
that
have
recently
raised
concerns
about
human
health
environmental
quality
due
their
great
prevalence,
degradation
resistance,
potential
toxicity.
This
review
focuses
on
the
applications
PFAS
effects
health.
Specific
emphasis
has
been
laid
(i)
application/use
PFAS,
(ii)
sources
distribution
in
diverse
compartments,
(iii)
impact
Significant
humans
are
associated
with
exposure
i.e.,
immunotoxicity,
thyroid
kidney
disorders,
cancer,
etc.
Conclusions
obtained
from
studies
demonstrate
inadequate
evidence
should
not
be
used
justify
delaying
risk
reduction
steps
for
alternatives.
can
determined
different
matrices
using
both
traditional
analytical
approaches,
liquid
chromatography
coupled
mass
spectrometry
(LC-MS/MS)
semi-quantitative
passive
sampling,
advanced
methods
colorimetric,
spectrofluorimetric,
electrochemical
detection.
Traditional
costly
broadly
available,
while
emerging,
cost-effective
less
sensitive
unable
meet
regulatory
limits.
There
is
still
significant
number
performed
fully
comprehend
real
contamination
by
PFAS.
Toxicological Sciences,
Journal Year:
2024,
Volume and Issue:
200(2), P. 213 - 227
Published: May 9, 2024
Abstract
Per-
and
polyfluoroalkyl
substances
(PFAS)
have
become
internationally
recognized
over
the
past
three
decades
as
persistent
organic
pollutants
used
in
production
of
various
consumer
industrial
goods.
Research
efforts
continue
to
gauge
risk
that
historically
used,
newly
produced,
PFAS
may
cause
human
health.
Numerous
studies
report
toxic
effects
on
liver
well
increased
serum
cholesterol
levels
adults.
A
major
concern
with
PFAS,
also
dubbed
“forever
chemicals,”
is
they
accumulate
kidney
persist
serum.
The
mechanisms
responsible
for
their
disposition
excretion
humans
are
poorly
understood.
better
understanding
interaction
transporters,
it
pertains
other
xenobiotics,
could
provide
mechanistic
insight
into
health
guide
toward
assessment
compounds
development.
This
review
summarizes
current
state
literature
emerging
relationships
(eg,
substrates,
inhibitors,
modulators
gene
expression)
between
specific
hepatic
transporters.
adaptive
toxicological
responses
hepatocytes
reveal
linkages
pathologies
epidemiological
findings
highlighted.
evidence
suggests
our
molecular
landscape
must
improve
determine
impact
expression
function
hepatocyte
transporters
play
a
key
role
or
xenobiotic
disposition.
From
here,
we
can
assess
what
these
changes
documented
outcomes.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(1), P. 43 - 43
Published: Jan. 5, 2024
Per-
and
Polyfluoroalkyl
Substances
(PFAS)
bioaccumulate
in
the
human
body,
presenting
potential
health
risks
cellular
toxicity.
Their
transport
mechanisms
interactions
with
tissues
circulatory
system
require
further
investigation.
This
study
investigates
interaction
of
six
PFAS
Human
Serum
Albumin
(HSA)
using
multi-spectroscopy,
DFT
a
molecular
dynamics
approach.
Multi-spectral
analysis
shows
that
perfluorononanoic
acid
(PFNA)
has
best
binding
capabilities
HSA.
The
order
constants
(298
K)
is
as
follows:
"Perfluorononanoic
Acid
(PFNA,
7.81
×
10
