Physiological effects of PFAS exposure in seabird chicks: A multi-species study of thyroid hormone triiodothyronine, body condition and telomere length in South Western France DOI
Manrico Sebastiano, William Jouanneau, Pierre Blévin

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 165920 - 165920

Published: July 30, 2023

Language: Английский

Estimation of per- and polyfluoroalkyl substances (PFAS) half-lives in human studies: a systematic review and meta-analysis DOI Creative Commons

Isabella Rosato,

Tiziano Bonato, Tony Fletcher

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 242, P. 117743 - 117743

Published: Nov. 25, 2023

Per- and polyfluoroalkyl substances (PFAS) constitute a heterogeneous group of synthetic compounds widely used in industrial applications. The estimation PFAS half-life (t1/2) is essential to quantify their persistence, toxicity mechanism action humans. purpose this review summarize the evidence on half-lives humans from available literature, investigate limitations uncertainties characterizing estimation. search was conducted PubMed, Scopus, Embase databases up July 03, 2023 aimed at identifying all papers that estimated human populations. We excluded studies temporal trends or providing estimates based solely renal clearance. As persistent ongoing exposures can influence estimation, we decided include only were after main source exposure had ceased. A random-effects meta-analysis reported perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS) perfluorohexanesulfonic (PFHxS) Risk bias evaluated using OHAT tool. total 13 articles included review, with 5 exposed general populations 8 workers; mean ranged 1.48 5.1 years for PFOA, 3.4 5.7 PFOS, 2.84 8.5 PFHxS. High heterogeneity among observed; potential reasons variability investigated populations, discrepancies considering exposures, isomeric compositions, accounting background exposure, time since stopped methods Despite efforts made better understand toxicokinetics, further are needed identify important characteristics these chemicals. Biomonitoring should focus unaccounted sources individual potentially determining half-life, ensure accurate estimates.

Language: Английский

Citations

72

Overview of Per- and Polyfluoroalkyl Substances (PFAS), Their Applications, Sources, and Potential Impacts on Human Health DOI Creative Commons
Zunaira Habib,

Minkyung Song,

Sadaf Ikram

et al.

Pollutants, Journal Year: 2024, Volume and Issue: 4(1), P. 136 - 152

Published: March 6, 2024

Per- and polyfluoroalkyl substances (PFAS) belong to a group of synthetic compounds that have recently raised concerns about human health environmental quality due their great prevalence, degradation resistance, potential toxicity. This review focuses on the applications PFAS effects health. Specific emphasis has been laid (i) application/use PFAS, (ii) sources distribution in diverse compartments, (iii) impact Significant humans are associated with exposure i.e., immunotoxicity, thyroid kidney disorders, cancer, etc. Conclusions obtained from studies demonstrate inadequate evidence should not be used justify delaying risk reduction steps for alternatives. can determined different matrices using both traditional analytical approaches, liquid chromatography coupled mass spectrometry (LC-MS/MS) semi-quantitative passive sampling, advanced methods colorimetric, spectrofluorimetric, electrochemical detection. Traditional costly broadly available, while emerging, cost-effective less sensitive unable meet regulatory limits. There is still significant number performed fully comprehend real contamination by PFAS.

Language: Английский

Citations

20

Effects of PFAS on human liver transporters: implications for health outcomes DOI Creative Commons
Ena Vujic, Stephen Ferguson, Kim L. R. Brouwer

et al.

Toxicological Sciences, Journal Year: 2024, Volume and Issue: 200(2), P. 213 - 227

Published: May 9, 2024

Abstract Per- and polyfluoroalkyl substances (PFAS) have become internationally recognized over the past three decades as persistent organic pollutants used in production of various consumer industrial goods. Research efforts continue to gauge risk that historically used, newly produced, PFAS may cause human health. Numerous studies report toxic effects on liver well increased serum cholesterol levels adults. A major concern with PFAS, also dubbed “forever chemicals,” is they accumulate kidney persist serum. The mechanisms responsible for their disposition excretion humans are poorly understood. better understanding interaction transporters, it pertains other xenobiotics, could provide mechanistic insight into health guide toward assessment compounds development. This review summarizes current state literature emerging relationships (eg, substrates, inhibitors, modulators gene expression) between specific hepatic transporters. adaptive toxicological responses hepatocytes reveal linkages pathologies epidemiological findings highlighted. evidence suggests our molecular landscape must improve determine impact expression function hepatocyte transporters play a key role or xenobiotic disposition. From here, we can assess what these changes documented outcomes.

Language: Английский

Citations

15

Ecological risk of per- and polyfluorinated alkyl substances in the phytoremediation process: a case study for ecologically keystone species across two generations DOI

Dezhan Liang,

Caibin Li,

Hanbo Chen

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 174962 - 174962

Published: July 26, 2024

Language: Английский

Citations

14

Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts DOI

Lucas Gaillard,

Robert Barouki,

Étienne Blanc

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

12

Deriving Membrane–Water and Protein–Water Partition Coefficients from In Vitro Experiments for Per- and Polyfluoroalkyl Substances (PFAS) DOI Creative Commons
Ruiwen Chen, Derek J. Muensterman, Jennifer A. Field

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

The phospholipid membrane-water partition coefficients (

Language: Английский

Citations

2

Fatty Acid Metabolic Impairment in Soil Microbes Induced by PFAS: Dependence on the Fluorocarbon Chain Length, Headgroups, and Ether Attached DOI

Enhui Wu,

Kun Wang,

Jingqing Zhou

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Per- and polyfluoroalkyl substances (PFASs) with varying chain lengths, headgroups, alternative structures are widespread persistent in soil, yet knowledge of their biological effects toxic mechanisms on soil microorganisms is limited. This study identified the structure-dependent impacts PFAS microbial fatty acid (FA) profiles by integrated field-laboratory investigations. The field investigation uncovered distinct PFAS-FA interaction patterns, fluorocarbon (FC) length functional group, FA hydrocarbon (HC) unsaturation degree. Specifically, long-chain perfluoroalkyl carboxylic acids (PFCAs, FC7-17) increased medium/long-chain FAs (HC ≤ 17) monounsaturated (MUFAs), while sulfonic (PFSAs, FC6-8) enhanced longer-chain > MUFAs. Additionally, perfluoroether (PFECAs) as well short-chain PFCAs (FC < 7) PFSAs 6), which commonly used alternatives to PFCAs/PFSAs, were associated polyunsaturated (PUFAs). laboratory Pseudomonas aeruginosa PAO1 validated these metabolic disruptions revealed broader perturbations phospholipids, acetyl-CoA, secondary metabolite metabolisms, providing insights into dysregulated membrane synthesis, C/N bacteria quorum sensing (QS) processes. These findings reveal novel PFASs microorganisms, highlighting potential biomarkers for assessing toxicity health.

Language: Английский

Citations

2

Estimation of species- and sex-specific PFAS pharmacokinetics in mice, rats, and non-human primates using a Bayesian hierarchical methodology DOI
Todd J. Zurlinden, Michael W. Dzierlenga, Dustin F. Kapraun

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117336 - 117336

Published: April 1, 2025

Language: Английский

Citations

1

The sources and bioaccumulation of per- and polyfluoroalkyl substances in animal-derived foods and the potential risk of dietary intake DOI
Yudong Xing, Yan Zhou, Xin Zhang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167313 - 167313

Published: Sept. 22, 2023

Language: Английский

Citations

23

Binding Affinity and Mechanism of Six PFAS with Human Serum Albumin: Insights from Multi-Spectroscopy, DFT and Molecular Dynamics Approaches DOI Creative Commons

Mingguo Peng,

Yang Xu,

Yao Wu

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(1), P. 43 - 43

Published: Jan. 5, 2024

Per- and Polyfluoroalkyl Substances (PFAS) bioaccumulate in the human body, presenting potential health risks cellular toxicity. Their transport mechanisms interactions with tissues circulatory system require further investigation. This study investigates interaction of six PFAS Human Serum Albumin (HSA) using multi-spectroscopy, DFT a molecular dynamics approach. Multi-spectral analysis shows that perfluorononanoic acid (PFNA) has best binding capabilities HSA. The order constants (298 K) is as follows: "Perfluorononanoic Acid (PFNA, 7.81 × 10

Language: Английский

Citations

9