Effects of Avermectins on the Environment Based on Its Toxicity to Plants and Soil Invertebrates—a Review

Water Air & Soil Pollution, Journal Year: 2022, Volume and Issue: 233(7)

Published: June 30, 2022

Language: Английский

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Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 244, P. 114081 - 114081

Published: Sept. 13, 2022

Excessive use of hard-to-degrade pesticides threatens the ecological health aquatic systems. This study aimed to investigate difenoconazole (DFZ) residues in environment induced neurotoxicity carp and underlying mechanisms. A total thirty-six carps were divided into three groups exposed 0, 0.5, 2.0 mg/L DFZ for 96 h, respectively. The alterations behavior blood-brain barrier (BBB) examined, potential mechanisms explored using immunological assays biochemical methods. results showed that exposure caused behavioral freezing, reduced feeding, neuronal necrosis carp. Mechanistically, triggered ROS accumulation destroyed balance between oxidation antioxidation with increased lipid peroxidation product MDA contents antioxidant enzymes SOD CAT activities brain by inhibiting NF-E2-related factor 2 (Nrf2) pathway. activation oxidative stress further tight junction proteins MMP levels, thereby destroying BBB leading leakage brain. Increased permeability additionally led nuclear kappa-B signaling-mediated inflammatory cytokine storm, exacerbating neuroinflammation. Meanwhile, activated mitochondria-associated apoptosis carp's up-regulating Bcl-2 associated X protein, cleaved-caspase3, cytochrome C decreasing B-cell lymphoma-2 levels. Interestingly, initiated a protective autophagic response via PI3K/AKT/TOR pathway intending counteract DFZ. Overall, we concluded at high concentrations systems disrupted resulted through inhibition Nrf2 pathway-mediated accumulation. provides reference monitoring new target treatment DFZ-induced

Language: Английский

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The widespread presence of triazole fungicides in greenhouse soils in Shandong Province, China: A systematic study on human health and ecological risk assessments

Environmental Pollution, Journal Year: 2023, Volume and Issue: 328, P. 121637 - 121637

Published: April 12, 2023

Language: Английский

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Combining time-resolved transcriptomics and proteomics data for Adverse Outcome Pathway refinement in ecotoxicology

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 869, P. 161740 - 161740

Published: Jan. 26, 2023

Conventional Environmental Risk Assessment (ERA) of pesticide pollution is based on soil concentrations and apical endpoints, such as the reproduction test organisms, but has traditionally disregarded information along organismal response cascade leading to an adverse outcome. The Adverse Outcome Pathway (AOP) framework includes at any level biological organization, providing opportunities use intermediate responses a predictive read-out for outcomes instead. Transcriptomic proteomic data can provide thousands points toxic exposure. Combining multiple omics types necessary comprehensive overview and, therefore, AOP development. However, it unclear if transcript protein are synchronized in time or lagged. To understand analysis multi-omics obtained same timepoint reveal one cascade, we studied time-resolved shifts gene abundance springtail Folsomia candida, ecotoxicological model, after exposure neonicotinoid insecticide imidacloprid. We analyzed transcriptome proteome every 12 h up 72 onset most pronounced shift both abundances was observed 48 Moreover, cross-correlation analyses indicate that genes displayed highest correlation between without time-lag. This demonstrates combined transcriptomic from time-point be used improvement. will promote development biomarkers presence insecticides chemicals with similar mechanism action soils.

Language: Английский

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Gut microbiota composition and gene expression changes induced in the Apis cerana exposed to acetamiprid and difenoconazole at environmentally realistic concentrations alone or combined

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: May 3, 2023

Apis cerana is an important pollinator of agricultural crops in China. In the environment, A. may be exposed to acetamiprid (neonicotinoid insecticide) and difenoconazole (triazole fungicide), alone or combination because they are commonly applied various crops. At present, our understanding toxicological effects on honey bee gut microbiomes limited. The primary objective this study was explore whether these two pesticides affect bees' microbiota analyze transcriptional head gut. study, adults were and/or by contaminated syrup at field-realistic concentrations for 10 days. Results indicated that chronic exposure did not survival food consumption, whereas decreased weight bees. 16S rRNA sequencing suggested mixture diversity index shaped composition bacteria microbiota, impact bacterial community. ITS sequence data showed neither affected fungal community structure. Meanwhile, we also observed significantly altered expression genes related detoxification immunity tissues. Furthermore, adverse effect health greater than a single mixture. Taken together, demonstrates induced changes microbiome gene expression.

Language: Английский

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Effect of difenoconazole fungicide on physiological responses and ultrastructural modifications in model organism Tetrahymena pyriformis

Ecotoxicology and Environmental Safety, Journal Year: 2019, Volume and Issue: 182, P. 109375 - 109375

Published: July 9, 2019

Language: Английский

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Insights into the effects of difenoconazole on the livers in male mice at the biochemical and transcriptomic levels

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 422, P. 126933 - 126933

Published: Aug. 17, 2021

Language: Английский

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Gene expression and morphological responses of Lolium perenne L. exposed to cadmium (Cd2+) and mercury (Hg2+)

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: May 27, 2021

Abstract Soil contamination with heavy metals is a major problem worldwide, due to the increasing impact mainly caused by anthropogenic activities. This research evaluated phytoremediation capacity of, Lolium perenne for such as cadmium (Cd 2+ ) and mercury (Hg ), effects of these on morphology, biomass production, changes gene expression. Seeds L. were exposed six concentrations Cd Hg in range 0 25 mg L −1 , two mixtures –Hg 2 . The Non-Observed Effect Level (NOEL) was established dose response curves expression specific genes applying commercially available quantitative reverse transcription (RT-qPCR) assay. There no significant effect when exposing seeds maximum concentration 0.1 mixtures, there negative effect. An increase that regulate antioxidant activity stress found plant metals. Given high tolerance analyzed reflected both, development its molecular response, results highlight phytoremediator potential.

Language: Английский

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Integrated metabolomics, transcriptomics, and proteomics analyses reveal co-exposure effects of polycyclic aromatic hydrocarbons and cadmium on ryegrass (Lolium perenne L.)

Environment International, Journal Year: 2023, Volume and Issue: 178, P. 108105 - 108105

Published: July 21, 2023

Cadmium (Cd) and polycyclic aromatic hydrocarbons (PAHs) are prominent soil contaminants found in industrial sites, their combined effects on plants not yet fully understood. To investigate the mechanisms underlying co-exposure of Cd PAHs identify key biomarkers for co-effects, an integrated analysis metabolomics, transcriptomics, proteomics was conducted ryegrass leaves cultivated soil. In nontarget metabolomics analysis, nine differentially expressed metabolites that were specifically induced by compound exposure identified. When with genes proteins, it determined major pathways involved response to co-stress linoleic acid metabolism phenylpropanoid biosynthesis. The upregulation 12,13-dihydroxy-9Z-octadecenoic downregulation sinapyl alcohol identified as typical biomarkers, respectively. Compared scenarios single exposures, disrupted oxidation acid, leading alterations profiles linoleate metabolites. Additionally, intensified hydroxylation, carboxylation, methylation processes, interfered reactions involving coenzyme A, thus inhibiting lignin production. As a result, oxidative stress elevated, cell wall defense system weakened. findings this study highlight ecological risks associated unique biological responses co-exposed polluted soils.

Language: Английский

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Effects of abamectin-based and difenoconazole-based formulations and their mixtures in Daphnia magna: a multiple endpoint approach

Ecotoxicology, Journal Year: 2020, Volume and Issue: 29(9), P. 1486 - 1499

Published: May 9, 2020

Language: Английский

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