Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission

Experimental & Molecular Medicine, Journal Year: 2021, Volume and Issue: 53(3), P. 301 - 309

Published: March 1, 2021

Abstract The concept of the antibiotic resistome was introduced just over a decade ago, and since then, active studies have been conducted. In present study, we describe previously established resistome, which encompasses all types resistance genes (ARGs), important findings from each One-Health sector considering this concept, thereby emphasizing significance approach in understanding ARG transmission. Cutting-edge research methodologies are essential for deciphering complex structure microbiomes humans, animals, environment. Based on recent achievements multiple sectors, future directions suggested to improve control transmission: (1) ranking critical ARGs their hosts; (2) transmission at interfaces sectors; (3) identifying selective pressures affecting emergence, transmission, evolution ARGs; (4) elucidating mechanisms that allow an organism overcome taxonomic barriers

Language: Английский

---

Advances in Metagenomics and Its Application in Environmental Microorganisms

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 17, 2021

Metagenomics is a new approach to study microorganisms obtained from specific environment by functional gene screening or sequencing analysis. studies focus on microbial diversity, community constitute, genetic and evolutionary relationships, activities, interactions relationships with the environment. Sequencing technologies have evolved shotgun high-throughput, next-generation (NGS), third-generation (TGS). NGS TGS shown advantage of rapid detection pathogenic microorganisms. With help algorithms, we can better perform taxonomic profiling prediction species. Functional metagenomics helpful screen bioactive substances genes metabolites. In this article, basic steps, classification, applications are reviewed.

Language: Английский

---

Traditional and Emerging Water Disinfection Technologies Challenging the Control of Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes

ACS ES&T Engineering, Journal Year: 2021, Volume and Issue: 1(7), P. 1046 - 1064

Published: June 7, 2021

The emergence of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in the environment has created obstacles when treating infectious diseases with antibiotics. Wastewater treatment plants (WWTPs) serve as reservoirs for ARB ARGs can disseminate them into environment. It is important to understand address these risks. Generally, professional disinfection processes have been used WWTPs disinfect target water body, goal eliminating pathogenic microorganisms water. However, are not generally considered, spread developed through horizontal gene transfer (HGT). This Review provides a detailed overview application progress different traditional new technologies removing ARGs, mainly focusing on bacterial inactivation mechanisms chlorination, ozonation, ultraviolet (UV) (including UVA, UVB, UVC), sunlight, sunlight-dissolved organic matter (DOM), photocatalysis (PC)/photoelectrocatalysis (PEC). In addition, this also focuses technology involved clarifies underlying environments. Furthermore, by linking inactivation, describes how SOS response cell membrane permeability may be key step conjugation, transformation, transduction ARGs. Finally, given applications current problems associated light-based controlling challenges opportunities facilitate development future technologies. highlights research directions related ARG transmission control.

Language: Английский

---

The spread of antibiotic resistance to humans and potential protection strategies

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 254, P. 114734 - 114734

Published: March 10, 2023

Antibiotic resistance is currently one of the greatest threats to human health. Widespread use and residues antibiotics in humans, animals, environment can exert selective pressure on antibiotic bacteria (ARB) gene (ARG), accelerating flow resistance. As ARG spreads population, burden humans increases, which may have potential health effects people. Therefore, it critical mitigate spread reduce load humans. This review briefly described information global consumption national action plans (NAPs) combat provided a set feasible control strategies for transmission ARB three areas including (a) Reducing colonization capacity exogenous ARB, (b) Enhancing mitigating horizontal transfer (HGT) ARG, (c) Reversing With hope achieving interdisciplinary one-health prevention bacterial

Language: Английский

---

Antimicrobial Resistance in Rivers: A Review of the Genes Detected and New Challenges

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 41(3), P. 687 - 714

Published: Feb. 22, 2022

Abstract River ecosystems are very important parts of the water cycle and an excellent habitat, food, drinking source for many organisms, including humans. Antibiotics emerging contaminants which can enter rivers from various sources. Several antibiotics their related antibiotic resistance genes (ARGs) have been detected in these by research programs could constitute a substantial problem. The presence other cofactors boost development ARGs chromosomes or mobile genetic elements natural bacteria rivers. environmental also be transferred to clinically pathogens. However, both not currently monitored national international authorities responsible controlling quality bodies. For example, they included contaminant list European Water Framework Directive US Water‐Quality Benchmarks Contaminants. Although naturally present environment, few studies focused on non‐impacted assess background ARG levels rivers, provide some useful indications future regulation legislation. study reviews associated most commonly measured primary analysis tools used assessment. In addition, factors that enhance resistance, such as effects chemical mixtures, climate change, potential coronavirus disease 2019 pandemic, discussed. Environ Toxicol Chem 2022;41:687–714. © 2022 SETAC

Language: Английский

---

Insight into nanozymes for their environmental applications as antimicrobial and antifouling agents: Progress, challenges and prospects

Nano Today, Journal Year: 2023, Volume and Issue: 48, P. 101755 - 101755

Published: Jan. 14, 2023

Language: Английский

---

Drinking water sources as hotspots of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs): Occurrence, spread, and mitigation strategies

Journal of Water Process Engineering, Journal Year: 2023, Volume and Issue: 53, P. 103907 - 103907

Published: June 16, 2023

Language: Английский

---

Interfacial engineering of BiVO4/PANI p-n heterojunction for enhanced photocatalytic degradation of p-nitrophenol: Pathway, toxicity evaluation and mechanistic insights

Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: 49, P. 104361 - 104361

Published: April 16, 2024

Language: Английский

---

Antibiotic contamination in wastewater treatment plant effluents: Current research and future perspectives

Environmental Nanotechnology Monitoring & Management, Journal Year: 2025, Volume and Issue: unknown, P. 101047 - 101047

Published: Jan. 1, 2025

Language: Английский

---

Ecological Consequences of Antibiotics Pollution in Sub-Saharan Africa: Understanding Sources, Pathways, and Potential Implications

Emerging contaminants, Journal Year: 2025, Volume and Issue: unknown, P. 100475 - 100475

Published: Jan. 1, 2025

Language: Английский

---