Serine
hydrolases,
as
a
class
of
green
catalysts
with
hydrolytic
and
dehydrating
activities,
hold
significant
application
value
in
the
fields
biosynthesis
organic
synthesis.
However,
practical
applications
face
numerous
challenges,
including
maintaining
enzyme
stability
managing
usage
costs.
PepNzymes-SH,
an
emerging
catalytic
material
enzyme-like
activity,
overcomes
operational
limitations
natural
enzymes
holds
great
promise
substitute
for
hydrolases.
Unfortunately,
systematic
review
design
strategies
PepNzymes-SH
is
currently
lacking.
The
core
significance
this
report
lies
providing
researchers
comprehensive
understanding
theoretical
guidance
through
summarization
performance
evaluation
different
PepNzymes-SH.
This
summarizes
simulating
enhancing
serine
hydrolase
active
sites,
oxyanion
holes,
hydrophobic
environmental
structures.
By
comparing
their
we
assess
changes
brought
about
by
strategies.
Furthermore,
chemical,
biomedicine,
are
also
discussed.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(44), P. 16383 - 16391
Published: Oct. 26, 2023
The
rational
design
of
efficient
nanozymes
and
the
immobilization
enzymes
are
great
significance
for
construction
high-performance
biosensors
based
on
nano-/bioenzyme
catalytic
systems.
Herein,
a
novel
V-TCPP(Fe)
metal-organic
framework
nanozyme
with
two-dimensional
nanosheet
morphology
is
rationally
designed
by
using
V2CTx
MXene
as
metal
source
iron
tetrakis(4-carboxyphenyl)porphine
(FeTCPP)
ligand
an
organic
linker.
It
exhibits
enhanced
peroxidase-
catalase-like
activities
luminol-H2O2
chemiluminescent
(CL)
behavior.
Based
experimental
theoretical
results,
these
excellent
enzyme-like
derived
from
two-site
synergistic
effect
between
V
nodes
FeTCPP
ligands
in
V-TCPP(Fe).
Furthermore,
confined
system
developed
zeolitic
imidazole
(ZIF)
coencapsulation
bioenzyme.
Using
acetylcholinesterase
(AChE)
model,
our
constructed
V-TCPP(Fe)/AChE@ZIF
was
successfully
used
colorimetric/CL
dual-mode
visual
biosensing
organophosphorus
pesticides.
This
work
expected
to
provide
new
insights
into
systems,
encouraging
applications
catalysis
biosensing.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 3, 2024
Abstract
Single‐atom
nanozymes
(SAzymes)
have
made
significant
strides
in
antibacterial
treatment
but
fall
short
as
natural
enzyme
and
drug
replacements
due
to
limited
catalytic
performance.
Here,
a
rational
strategy
is
presented
for
incorporating
spatially
axial
boron
(B)
ligands
effectively
modulate
the
local
coordination
environment
of
planar
Fe─N
4
motifs
(Fe─B/N─C
SAzymes).
With
electronic
modulation,
Fe─B/N─C
SAzymes
exhibit
significantly
enhanced
oxidase‐,
peroxidase‐,
catalase‐like
activities.
Theoretical
calculations
highlight
that
B
adjust
charge
distribution
around
active
center,
which
facilitates
heterolysis
H
2
O
desorption
,
resulting
accelerated
decomposition.
Furthermore,
intrinsic
photothermal
effect
enhances
multienzyme‐like
activities,
rapidly
generating
abundant
reactive
oxygen
species
(ROS),
achieving
chemodynamic/photothermal
synergistic
therapy
impressive
disinfection
against
periodontal‐related
pathogenic
bacteria.
These
findings
offer
distinctive
viewpoint
optimizing
with
ligand
enhance
their
performance
effectiveness
periodontitis
therapy.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(15), P. 19828 - 19837
Published: April 3, 2024
Passive
radiative
cooling
(PRC)
is
a
zero-energy-consumption
technology
that
reflects
sunlight
and
radiates
heat
to
cold
outer
space.
In
this
work,
porous
poly(vinylidene
fluoride)–poly(methyl
methacrylate)
(PVDF–PMMA)
composite
film
fabricated
by
decorating
zinc-imidazolate
metal–organic
framework
(MOF)
(ZIF-8)
particles
obtained
phase
inversion.
Due
the
competent
scattering
via
coral-like
hierarchical
structures
vibration
excitations
of
specific
functional
groups,
prepared
exhibits
good
solar
reflectance
(92.6%)
intermediate
infrared
emittance
(99.1%),
with
an
average
sub-ambient
10.4
°C
under
radiation
intensity
0.6
AM1.5.
Additionally,
fluoride)
has
low
surface
energy,
while
ZIF-8
enhance
roughness,
endowing
significant
superhydrophobicity
characterized
water
contact
angle
(WCA)
157.5°
sliding
(SA)
2°.
These
films
exhibit
excellent
antibacterial
properties.
When
content
in
300
mg·L–1,
rate
reaches
100%
after
1
h
treatment.
Thus,
(ZPPP)
potential
application
prospects
areas
high
health
environmental
requirements,
such
as
chain
transportation
public
spaces.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
265, P. 130960 - 130960
Published: March 20, 2024
Tumors
remain
one
of
the
major
threats
to
public
health
and
there
is
an
urgent
need
design
new
pharmaceutical
agents
for
their
diagnosis
treatment.
In
recent
years,
due
rapid
development
nanotechnology,
biotechnology,
catalytic
science,
theoretical
computing,
subtlety
has
gradually
made
great
progress
in
research
related
tumor
Compared
conventional
drugs,
enzymes
can
improve
drug
distribution
enhance
enrichment
at
site,
thereby
reducing
side
effects
enhancing
efficacy.
Nanozymes
also
be
used
as
tracking
imaging
reshape
microenvironment,
providing
a
versatile
platform
treatment
malignancies.
this
paper,
we
review
current
status
on
oncology
analyze
novel
therapeutic
approaches
mechanisms.
To
date,
large
number
nanomaterials,
such
noble
metal
nonmetallic
carbon-based
have
been
shown
able
function
like
natural
enzymes,
particularly
with
significant
advantages
therapy.
light
this,
authors
systematically
summarized
evaluated
construction,
enzymatic
activity,
characteristics
nanozymes
respect
modalities
addition,
application
different
types
nicknames
features
years
are
detail.
We
conclude
summary
outlook
study
It
hoped
that
will
inspire
researchers
fields
chemistry,
biology,
materials
science
contribute
nano-enzymology.
