Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: July 21, 2021

Rising antibiotic resistance is a global threat that projected to cause more deaths than all cancers combined by 2050. In this review, we set summarize the current state of resistance, and give an overview emerging technologies aimed escape pre-antibiotic era recurrence. We conducted comprehensive literature survey >150 original research review articles indexed in Web Science using “antimicrobial resistance,” “diagnostics,” “therapeutics,” “disinfection,” “nosocomial infections,” “ESKAPE pathogens” as key words. discuss impact nosocomial infections on spread multi-drug resistant bacteria, over existing developing strategies for faster diagnostics infectious diseases, novel approaches therapy finally hospital disinfection prevent MDR bacteria spread.

Language: Английский

---

Genomic surveillance for antimicrobial resistance — a One Health perspective

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(2), P. 142 - 157

Published: Sept. 25, 2023

Language: Английский

---

Antibiotic resistance in soil-plant systems: A review of the source, dissemination, influence factors, and potential exposure risks

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 869, P. 161855 - 161855

Published: Jan. 25, 2023

Language: Английский

---

Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 860, P. 160461 - 160461

Published: Nov. 24, 2022

Language: Английский

---

Antimicrobial Resistance in Rivers: A Review of the Genes Detected and New Challenges

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 41(3), P. 687 - 714

Published: Feb. 22, 2022

Abstract River ecosystems are very important parts of the water cycle and an excellent habitat, food, drinking source for many organisms, including humans. Antibiotics emerging contaminants which can enter rivers from various sources. Several antibiotics their related antibiotic resistance genes (ARGs) have been detected in these by research programs could constitute a substantial problem. The presence other cofactors boost development ARGs chromosomes or mobile genetic elements natural bacteria rivers. environmental also be transferred to clinically pathogens. However, both not currently monitored national international authorities responsible controlling quality bodies. For example, they included contaminant list European Water Framework Directive US Water‐Quality Benchmarks Contaminants. Although naturally present environment, few studies focused on non‐impacted assess background ARG levels rivers, provide some useful indications future regulation legislation. study reviews associated most commonly measured primary analysis tools used assessment. In addition, factors that enhance resistance, such as effects chemical mixtures, climate change, potential coronavirus disease 2019 pandemic, discussed. Environ Toxicol Chem 2022;41:687–714. © 2022 SETAC

Language: Английский

---

An Overview of Antimicrobial Stewardship Optimization: The Use of Antibiotics in Humans and Animals to Prevent Resistance

Antibiotics, Journal Year: 2022, Volume and Issue: 11(5), P. 667 - 667

Published: May 16, 2022

Antimicrobials are a type of agent widely used to prevent various microbial infections in humans and animals. Antimicrobial resistance is major cause clinical antimicrobial therapy failure, it has become public health concern around the world. Increasing development multiple antimicrobials available for animals with no appropriate guidance. As result, inappropriate use significantly produced resistance. However, an increasing number such as sepsis untreatable due this In either case, life-saving drugs rendered ineffective most cases. The actual causes complex versatile. A lack adequate services, unoptimized animals, poor water sanitation systems, wide gaps access research healthcare technologies, environmental pollution have vital impacts on This current review will highlight natural history basics antimicrobials, relationship between simplistic pathways, mechanisms resistance, how control spread

Language: Английский

---

Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs?

Environment International, Journal Year: 2023, Volume and Issue: 178, P. 108089 - 108089

Published: July 6, 2023

Antimicrobial resistance (AMR) is a global threat to human and animal health well-being. To understand AMR dynamics, it important monitor resistant bacteria genes in all relevant settings. However, while monitoring of has been implemented clinical veterinary settings, comprehensive the environment almost completely lacking. Yet, environmental dimension critical for understanding dissemination routes selection microorganisms, as well risks related AMR. Here, we outline knowledge gaps that impede implementation monitoring. These include lack 'normal' background levels AMR, definition high-risk environments transmission, poor concentrations antibiotics other chemical agents promote selection. Furthermore, there methods detect are not already circulating among pathogens. We conclude these need be addressed before routine can on large scale. data bridging different sectors needed order fill gaps, which means some level national, regional surveillance must happen even without scientific questions answered. With possibilities opened up by rapidly advancing technologies, time gaps. Doing so will allow specific actions against development spread pathogens thereby safeguard wellbeing humans animals.

Language: Английский

---

Deterministic Effect of pH on Shaping Soil Resistome Revealed by Metagenomic Analysis

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(2), P. 985 - 996

Published: Jan. 5, 2023

Soil is recognized as the major reservoir of antibiotic resistance genes (ARGs), harboring most diverse naturally evolved ARGs on planet. Multidrug are a class ARGs, and their high prevalence in natural soil ecosystems has recently raised concerns. Since these express proton motive force (PMF) driven efflux pumps, studying whether pH determinant for selection multidrug pump thus shaping resistome great interest. In this study, we collected 108 soils with values ranging from 4.37 to 9.69 multiple profiled composition metagenomes metagenome-assembled genomes. We observed enriched acidic resistome, abundances have significant dependence. This reflects benefits activity genes, especially PMF-driven inner membrane transferase. addition, preliminary indicate putative microbial participants by applying ecological analyzing tools such stepwise regression random forest model fitting. The decisive influence more impactful than any other examined factors, consequence, revisited edaphic factors resistome; i.e., deterministic mechanisms could lead bottom-up ARG composition. Such developing herein suggested be considered assessing human-driven transmissions.

Language: Английский

---

Reservoirs of antimicrobial resistance in the context of One Health

Current Opinion in Microbiology, Journal Year: 2023, Volume and Issue: 73, P. 102291 - 102291

Published: March 11, 2023

The emergence and spread of antimicrobial resistance (AMR) resistant bacteria, are a global public health challenge. Through horizontal gene transfer, potential pathogens can acquire genes (ARGs) that subsequently be between human, animal, environmental reservoirs. To understand the dissemination ARGs linked microbial taxa, it is necessary to map resistome within different By integrating knowledge on in reservoirs, One Health approach crucial our understanding complex mechanisms epidemiology AMR. Here, we highlight latest insights into AMR from perspective, providing baseline for future scientific investigations this constantly growing threat.

Language: Английский

---

Latent antibiotic resistance genes are abundant, diverse, and mobile in human, animal, and environmental microbiomes

Microbiome, Journal Year: 2023, Volume and Issue: 11(1)

Published: March 8, 2023

Abstract Background Bacterial communities in humans, animals, and the external environment maintain a large collection of antibiotic resistance genes (ARGs). However, few these ARGs are well-characterized thus established existing gene databases. In contrast, remaining latent typically unknown overlooked most sequencing-based studies. Our view resistome its diversity is therefore incomplete, which hampers our ability to assess risk for promotion spread yet undiscovered determinants. Results A reference database consisting both (ARGs not present current repositories) was created. By analyzing more than 10,000 metagenomic samples, we showed that were abundant diverse all studied environments, including human- animal-associated microbiomes. The pan-resistomes, i.e., an environment, heavily dominated by ARGs. comparison, core-resistome, commonly encountered, comprised We identified several shared between environments and/or human pathogens. Context analysis they located on mobile genetic elements, conjugative elements. We, furthermore, wastewater microbiomes had surprisingly pan- makes it potentially high-risk mobilization Conclusions results show ubiquitously constitute reservoir from new determinants can be recruited Several already high potential pathogens, suggesting may emerging threats health. conclude full resistome—including ARGs—needs considered properly risks associated with selection pressures.

Language: Английский

---