Prenatal phthalate exposure and anogenital distance in infants at 12 months DOI Creative Commons
Kim N. Cajachagua‐Torres,

Nicole B. Salvi,

Eunsil Seok

et al.

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109472 - 109472

Published: April 15, 2025

Anogenital distance (AGD) is a postnatal marker of in utero exposure to androgens and anti-androgens, predictor reproductive health. We examined the association between gestational phthalates AGD male female infants. In 506 mother-infant pairs (276 males, 230 females), we measured urinary concentrations phthalate metabolites at < 18 18-25 weeks gestation child age 12.9 months (95 % range 11.4-21.1). Phthalate metabolite were adjusted for dilution, averaged, natural log-transformed. anus-clitoris (AGDac) anus-fourchette (AGDaf) females, anus-scrotum distance, anus-penis penile width males. used linear regression partial-linear single-index (PLSI) models examine associations as single pollutants mixture. Fifty-eight percent mothers Hispanic, followed by 27 non-Hispanic White. Higher exposures ∑di-isononyl(phthalate) (∑DiNP) was associated with longer AGDaf [1.28 mm confidence interval [CI]: 0.52, 2.03) 0.97 %CI: 0.25, 1.69), respectively]. ∑di(2-ethylhexyl)phthalate (∑DEHP) AGDac [2.80 1.17, 4.44), 1.90 0.76, 3.04), No observed males after multiple testing correction. mixture analyses, ∑DiNP ∑DEHP main contributors females. also detected an interaction Early pregnancy Biological mechanisms underlying these should be further investigated.

Language: Английский

Widespread pesticide contamination of drinking water and impact on cancer risk in Brazil DOI Creative Commons
Carolina Panis, Luciano Zanetti Pessôa Candiotto, Shaiane Carla Gaboardi

et al.

Environment International, Journal Year: 2022, Volume and Issue: 165, P. 107321 - 107321

Published: June 3, 2022

Pesticides, which are associated with endocrine dysfunction, immunological dysregulation, and cancer, widespread sources of drinking water contamination. The state Paraná has a population 11 million, is the second largest grain producer in Brazil leading consumer pesticides. In this study, we analyzed extent contamination from proven, probable, or potentially carcinogenic pesticides (alachlor, aldrin-dieldrin, atrazine, chlordane, DDT-DDD-DDE, diuron, glyphosate-AMPA, lindane-γ-HCH, mancozeb-ETU, molinate, trifluralin) 127 grain-producing municipalities Paraná. Extensive was found, including legacy such as aldrin-dieldrin (mean 0.047 ppb), DDT-DDD-DDE (mean: 0.07), chlordane 0.181), lindane-HCH 2.17). Most were significantly above maximum limits for each one currently allowed (67% alachlor, 9.44% 96.85% 100% 80.31% 91.33% 12.6% trifluralin). Ninety-seven percent presented sum all at levels (189.84 ppb) European Union preconized (<0.5 ppb). Using mean pesticide concentration (ppb), exposed municipality, benchmark cancer risk pesticides, estimated minimum number cases attributable to pesticide-contaminated during period (total 542 cases). More than 80% attributed mancozeb-ETU diuron. Glyphosate-AMPA diuron-attributable strongly correlated total same (R = 0.8117 0.8138, respectively) well breast 0.7695 0.7551, respectively). Water detected city 0.58 p < 0.0001). These findings reveal extensive suggest that may increase region.

Language: Английский

Citations

111
Enzyme-free and rapid visual quantitative detection for pesticide residues utilizing portable smartphone integrated paper sensor DOI
Qianru Zhang, Zhong Zhang, Shihao Xu

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 436, P. 129320 - 129320

Published: June 9, 2022

Language: Английский

Citations

86
Quantifiable urine glyphosate levels detected in 99% of the French population, with higher values in men, in younger people, and in farmers DOI Creative Commons

Daniel Grau,

Nicole Grau,

Quentin Gascuel

et al.

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(22), P. 32882 - 32893

Published: Jan. 12, 2022

France is the first pesticide-consuming country in Europe. Glyphosate most used pesticide worldwide and glyphosate detected general population of industrialized countries, with higher levels found farmers children. Little data was available concerning exposure France. Our objective to determine French search for an association seasons, biological features, lifestyle status, dietary habits, occupational exposure. This study includes 6848 participants recruited between 2018 2020. Associated include age, gender, location, employment information. quantified by a single laboratory first-void urine samples using ELISA. results support contamination population, quantifiable 99.8% mean 1.19 ng/ml + / - 0.84 after adjustment body mass index (BMI). We confirm men through food water intake, as lower are associated dominant organic intake filtered water. Higher confirmed working wine-growing environment. Thus, our present show glyphosate, further contribute description widespread countries.

Language: Английский

Citations

66
Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders DOI Creative Commons

Joanna K. Winstone,

Khyatiben V. Pathak, Wendy Winslow

et al.

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: July 28, 2022

Abstract Background Herbicides are environmental contaminants that have gained much attention due to the potential hazards they pose human health. Glyphosate, active ingredient in many commercial herbicides, is most heavily applied herbicide worldwide. The recent rise glyphosate application corn and soy crops correlates positively with increased death rates Alzheimer’s disease other neurodegenerative disorders. Glyphosate has been shown cross blood–brain barrier vitro models, but yet be verified vivo. Additionally, reports exposure increases pro-inflammatory cytokines blood plasma, particularly TNFα. Methods Here, we examined whether infiltrates brain elevates TNFα levels 4-month-old C57BL/6J mice. Mice received either 125, 250, or 500 mg/kg/day of glyphosate, a vehicle via oral gavage for 14 days. Urine, samples were collected on final day dosing analysis UPLC–MS ELISAs. Primary cortical neurons derived from amyloidogenic APP/PS1 pups evaluate changes Aβ 40-42 burden cytotoxicity. RNA sequencing was performed determine transcriptome. Results Our revealed infiltrated dose-dependent manner upregulated both plasma tissue post-exposure. Notably, measures correlated levels. primary soluble RNAseq over 200 differentially expressed genes cell-type-specific deconvolution showed enrichment key biological processes oligodendrocytes including myelination, axon ensheathment, glial cell development, oligodendrocyte development. Conclusions Collectively, these results show first time brain, expression Aβ, disrupts transcriptome manner, suggesting this may detrimental outcomes regarding health general population.

Language: Английский

Citations

49
Prenatal perfluoroalkyl substances exposure and maternal sex steroid hormones across pregnancy DOI Creative Commons
Zorimar Rivera‐Núñez, Carolyn Waugh Kinkade,

Leena Khoury

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 220, P. 115233 - 115233

Published: Jan. 5, 2023

Poly- and perfluoroalkyl substances (PFAS) are ubiquitous persistent environmental contaminants that may act as endocrine disruptors in utero, but the specific pathways unknown. We examined associations between maternal serum PFAS sex steroid hormones at three time points during pregnancy. Pregnant women participating Understanding Pregnancy Signals Infant Development (UPSIDE) study contributed biospecimens, questionnaire, medical record data each trimester (n = 285). (including perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS), perfluorohexane sulfonic (PFHxS), perfluorononanoic (PFNA) perfluorodecanoic (PFDA)) were analyzed second-trimester samples by high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS). Total testosterone [TT], free [fT], estrone [E1], estradiol [E2], estriol [E3]) measured LC-MS/MS from trimester. Linear mixed models with random intercepts used to examine log-transformed concentrations hormone levels, adjusting for covariates, stratifying fetal sex. Results presented mean percentage difference (Δ%) levels per ln-unit increase concentration. In adjusted models, PFHxS was associated higher TT (%Δ 20.0, 95%CI: 1.7, 41.6), particularly among carrying male fetuses 15.3, 1.2, 30.7); this association strengthened pregnancy progressed. PFNA 7.9, 3.4, 12.5) PFDA 7.2, 4.9, 9.7) fT, again observed only fetuses. of E2 E3 female 13.2, 0.5, 29.1; %Δ 17.9, 3.2, 34.8, respectively). No PFOS PFOA. PFHxS, PFNA, disrupt androgenic estrogenic a sex-dependent manner.

Language: Английский

Citations

37
Glyphosate and environmental toxicity with “One Health” approach, a review DOI
Margherita Ferrante, Paola Rapisarda,

Alfina Grasso

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 235, P. 116678 - 116678

Published: July 15, 2023

Language: Английский

Citations

31
Biomonitoring of glyphosate and aminomethylphosphonic acid: Current insights and future perspectives DOI

Xin Wei,

Yanan Pan, Ziqi Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 463, P. 132814 - 132814

Published: Oct. 20, 2023

Language: Английский

Citations

24
A dual quantum dots-based ratio fluorescent probe for detecting Glyphosate in agricultural products DOI
Qian Xiang, Wei Geng,

Xiaoqi Guo

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113214 - 113214

Published: Feb. 1, 2025

Language: Английский

Citations

1
Urinary glyphosate concentration in pregnant women in relation to length of gestation DOI Creative Commons
Corina Lesseur, Khyatiben V. Pathak, Patrick Pirrotte

et al.

Environmental Research, Journal Year: 2021, Volume and Issue: 203, P. 111811 - 111811

Published: July 30, 2021

Language: Английский

Citations

44
Urinary concentrations and determinants of glyphosate and glufosinate in pregnant Canadian participants in the MIREC study DOI Creative Commons
Jillian Ashley‐Martin,

Rong Huang,

Susan MacPherson

et al.

Environmental Research, Journal Year: 2022, Volume and Issue: 217, P. 114842 - 114842

Published: Nov. 18, 2022

Glyphosate is the most widely applied herbicide in agriculture. Glufosinate a broad spectrum used to manage glyphosate-resistant weeds. Despite widespread use of these herbicides, biomonitoring data – which inform risk assessment and management are sparse. To identify determinants urinary concentrations herbicides their metabolites pregnancy. We measured glyphosate, glufosinate, primary aminomethylphosphonic acid (AMPA) 3-methylphosphinicopropionic (3-MPPA) single spot urine specimen collected during first trimester pregnancy from Maternal-Infant Research on Environmental Chemicals (MIREC) study. MIREC recruited about 2000 pregnant women 10 Canadian cities between 2008 2011. UItra-Performance Liquid Chromatography coupled tandem mass spectrometry (UPLC-MS/MS) with sensitive limits detection quantify analyte concentrations. examined according maternal sociodemographics, sample collection characteristics, reported pesticide use, consumption fruits, vegetables, legumes, grain products. ANOVA models specific gravity-standardized chemical as dependent variable determine associations determinants. Among biobanked samples (n = 1829–1854), 74% 72% had detectable glyphosate AMPA, respectively. In contrast, one six percent glufosinate 3-MPPA, The geometric mean (95% CI) AMPA were 0.112 (0.099–0.127) μg/L 0.159 (0.147–0.172) μg/L, observed dose-response relationship whole bread higher Season self-reported not associated increased any analyte. detected majority this predominantly urban cohort. Diet was probable route exposure.

Language: Английский

Citations

31