Design, Synthesis, and Antifungal/Antioomycete Activity of Thiohydantoin Analogues Containing Spirocyclic Butenolide DOI
Yihao Li, Tingting Zhang, Haoyun Ma

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(16), P. 6249 - 6267

Published: April 14, 2023

Novel fungicidal agents were designed based on the combination of two privileged scaffolds, thiohydantoin and spirocyclic butenolide, which are widely found in natural products. The synthesized compounds characterized by 1H NMR, 13C high-resolution electrospray ionisation mass spectrometry. vitro antioomycete activity evaluation showed that most exhibited excellent inhibitory activities against different developmental stages life cycle pathogenic oomycete Phytophthora capsici. Compound 5j could inhibit mycelial growth, sporangium production, zoospore release, cystospore germination significantly with EC50 values 0.38, 0.25, 0.11, 0.026 μg/mL, respectively. vivo antifungal/antioomycete bioassay results revealed series generally outstanding control efficacies Pseudoperonospora cubensis, 5j, 5l, 7j, 7k, 7l possessed broad-spectrum antifungal test phytopathogens. protective curative P. capsici representative compound excellent, better than those azoxystrobin. More prominently, promoted biomass accumulation root system reinforced cell wall callose deposition. pronounced upregulation immune response-related genes indicated active inhibitor also functioned as a plant elicitor. Transmission electron microscopy observation enzyme demonstrated mechanism action was to bind pivotal protein, complex III respiratory chain, resulted shortage energy supply. Molecular docking appropriately matched Qo pocket had no interaction commonly mutated site Gly-142, may be significant benefit fungicide resistance management. great advantages potential control, management, induction disease resistance. A further investigation unique structure might have direct implications for creation novel inhibitors plant-pathogenic oomycetes.

Language: Английский

Excellent photocatalytic and antibacterial activities of bio-activated carbon decorated magnesium oxide nanoparticles DOI
Muhammad Yahya, Mika Sillanpää, Tahani Mazyad Almutairi

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 312, P. 137327 - 137327

Published: Nov. 18, 2022

Language: Английский

Citations

43
Impact of per- and polyfluorinated alkyl substances (PFAS) on the marine environment: Raising awareness, challenges, legislation, and mitigation approaches under the One Health concept DOI Creative Commons
Lada Lukić‐Bilela, Inga Matijošytė, Jokūbas Krutkevičius

et al.

Marine Pollution Bulletin, Journal Year: 2023, Volume and Issue: 194, P. 115309 - 115309

Published: Aug. 15, 2023

Per- and polyfluorinated alkyl substances (PFAS) have long been known for their detrimental effects on the ecosystems living organisms; however long-term impact marine environment is still insufficiently recognized. Based PFAS persistence bioaccumulation in complex food network, adverse will be exacerbated by global processes such as climate change synergies with other pollutants, like microplastics. The range of fluorochemicals currently included umbrella has significantly expanded due to updated OECD definition, raising new concerns about poorly understood dynamics negative ocean wildlife human health. Mitigation challenges approaches, including biodegradation studied materials environmental removal are proposed here, highlighting importance ongoing monitoring bridging research gaps. EU regulations, good practices legal frameworks discussed, emphasis recommendations improving ecosystem management.

Language: Английский

Citations

40
Facile and large-scale synthesis of trifluoromethyl-grafted covalent organic framework for efficient microextraction and ultrasensitive determination of benzoylurea insecticides DOI

Chenchen Song,

Yake Luo,

Juan Zheng

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 462, P. 142220 - 142220

Published: March 2, 2023

Language: Английский

Citations

28
Research Progress of Benzothiazole and Benzoxazole Derivatives in the Discovery of Agricultural Chemicals DOI Open Access
Yue Zou,

Yong Zhang,

Xing Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10807 - 10807

Published: June 28, 2023

Benzoxazole and benzothiazole have a broad spectrum of agricultural biological activities, such as antibacterial, antiviral, herbicidal which are important fused heterocyclic scaffold structures in agrochemical discovery. In recent years, great progress has been made the research benzoxazoles benzothiazoles, especially development herbicides insecticides. With widespread use there may be more new products containing benzothiazoles future. We systematically reviewed application discovering agrochemicals past two decades summarized fungicidal, herbicidal, insecticidal activities active compounds. also discussed structural-activity relationship mechanism This work aims to provide inspiration ideas for discovery based on benzoxazole benzothiazole.

Language: Английский

Citations

24
Plant Biostimulant as an Environmentally Friendly Alternative to Modern Agriculture DOI

Yanke Jiang,

Yingzhe Yue,

Zhaoxu Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(10), P. 5107 - 5121

Published: March 1, 2024

Ensuring the safety of crop production presents a significant challenge to humanity. Pesticides and fertilizers are commonly used eliminate external interference provide nutrients, enabling crops sustain growth defense. However, addition chemical substances does not meet environmental standards required for agricultural production. Recently, natural sources such as biostimulants have been found help plants with The development provides new solutions product has become widely utilized tool in agricultural. review summarizes classification biostimulants, including humic-based biostimulant, protein-based oligosaccharide-based metabolites-based inorganic substance, microbial inoculant. This attempts summarize suitable alternative technology that can address problems analyze current state research mechanisms, anticipates future technological developments market trends, which comprehensive information researchers develop biostimulants.

Language: Английский

Citations

14
Forever Pesticides: A Growing Source of PFAS Contamination in the Environment DOI Creative Commons
Nathan Donley, Caroline Cox,

K. P. Bennett

et al.

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(7)

Published: July 1, 2024

Environmental contamination by fluorinated chemicals, in particular chemicals from the per- and polyfluoroalkyl substances (PFAS) class, has raised concerns around globe because of documented adverse impacts on human health, wildlife, ecosystem quality. Recent studies have indicated that pesticide products may contain a variety meet PFAS definition, including active ingredients themselves. Given pesticides are some most widely distributed pollutants across world, legacy addition into could be widespread wide-ranging implications agriculture food water contamination, as well presence rural environments.

Language: Английский

Citations

14
The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models DOI Creative Commons
Yanan Liu, Fengzhong Wang, Lin Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117615 - 117615

Published: Jan. 1, 2025

Environmental endocrine disruptors constitute a category of exogenous compounds that interfere with the system's functions in organisms or cells. As class particularly representative endocrine-disrupting chemicals, accumulation per- and polyfluoroalkyl substances potentially leads to adverse health effects, including hormonal disruptions, developmental issues, cancer. However, classification these is intricate, data on their potential risks scattered. The research into fluorinated pesticides somewhat superficial, majority review articles this field focusing structural characteristics, biodegradation processes, environmental associated pesticides. In study, we compared investigated development processes seven types fluorine-containing five disruptors. varying toxic effects are highly dependent exposure conditions. Their actions complex, affecting behavioral throughout organism, monitoring some complex biological phenotypes, sex- age-specific learning poses significant challenges. findings will serve as reference for future studies toxicity humans other organisms.

Language: Английский

Citations

1
Fluorine mass balance analysis of PFAS in communal waters at a wastewater plant from Austria DOI Creative Commons

Viktoria Müller,

Andrew Kindness, Jörg Feldmann

et al.

Water Research, Journal Year: 2023, Volume and Issue: 244, P. 120501 - 120501

Published: Aug. 18, 2023

Wastewater treatment plants are a major source of per and polyfluoroalkyl substances (PFAS) in the environment; moreover, long chain PFAS known to accumulate sewage sludge. Although publications on wastewater available from around globe, little information is Central Europe. In this study influent, effluent, sludge two Austria were analysed for target compounds with HPLC MS/MS extractable organic fluorine (EOF) content combustion ion chromatography (CIC). The sum 31 increased 22 – 47 ng L 1 influent 140 213 effluent 10 g sludge, while EOF found be consistent (2.3 3.5 µg F 1) influent/effluent 280 Mass balance analysis showed an increase identified compared (from 0.9% - 1.3% 3.6% 6.1%), suggesting biotransformation non-targeted precursor compounds. conclusion, transform some PFAS, contamination surface water.

Language: Английский

Citations

21
Hibiscus cannabinus seeds assisted spherical silver nanoparticles and its antibacterial and photocatalytic applications DOI Creative Commons

S. Smonia Joe Princy,

C. Hentry,

Hissah Abdulrahman Alodaini

et al.

Chemical Physics Impact, Journal Year: 2023, Volume and Issue: 6, P. 100192 - 100192

Published: March 21, 2023

Language: Английский

Citations

20
Plant‐derived artificial miRNA effectively reduced the proliferation of aphid (Aphidoidea) through spray‐induced gene silencing DOI
Yuan Wang,

Xuanlin Li,

Chenghong Zhu

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: 80(9), P. 4322 - 4332

Published: April 22, 2024

Abstract BACKGROUND Aphids (Hemiptera: Aphididae) are notorious sap‐sucking insects that rampantly threaten agricultural production worldwide. Current management against aphids in the field heavily relies on chemical pesticides, which makes economical and eco‐friendly methods urgently needed. Spray‐induced gene silencing (SIGS) offers a powerful precise approach to pest management. However, high costs instability of double‐stranded RNA (dsRNA) regulators applied for downstream interference (RNAi) still limit this strategy. It remains uncertain if RNAi SIGS could extend small (sRNA), especially miRNA. RESULTS We chose two sRNA sequences, miR‐9b miR‐VgR, whose corresponding targets ABCG4 VgR both essential aphid growth development. The efficacy these sequences was initially verified by chemically synthetic single‐stranded (syn‐ssRNA). Through spray treatment, we observed significantly decreased survival number increased abnormality rate green peach fed host under laboratory conditions. Based our previous study, generated transgenic plants expressing artificial (amiR‐9b) miR‐VgR (amiR‐VgR). Remarkably, plant‐derived amiRNA exerted potent long‐lasting inhibitory with merely one percent concentration synthetics. Notably, simultaneous application amiR‐9b amiR‐VgR exhibited superior efficacy. CONCLUSION explored potential use sRNA‐based biopesticide through while investigating dosage requirements. To optimize strategy, utilization proposed. results suggested attributed stability durability, deploying is promising solution application. © 2024 Society Chemical Industry.

Language: Английский

Citations

7