Published: Jan. 1, 2025
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 17, 2024
Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.
Language: Английский
Citations
45
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117868 - 117868
Published: Feb. 1, 2025
Language: Английский
Citations
6
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: Aug. 19, 2022
Progressive loss of physiological integrity and accumulation degenerative changes leading to functional impairment increased susceptibility diseases are the main features aging. The ovary, key organ that maintains female reproductive endocrine function, enters aging earlier faster than other organs has attracted extensive attention from society. Ovarian is mainly characterized by progressive decline in number quality oocytes, regulatory mechanisms which have yet be systematically elucidated. This review discusses hallmarks further highlight characteristics ovarian attempt explore its clinical symptoms underlying mechanisms. Finally, intervention strategies related elaborated, especially potential role stem cells cryopreservation embryos, or tissue delay
Language: Английский
Citations
43
The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 903, P. 166258 - 166258
Published: Aug. 12, 2023
In recent years, microplastics (MPs) and nanoplastics (NPs) have caused ubiquitous environmental pollution raised widespread concern about their potential toxicity to human health, especially in the reproductive system. Moreover, infertility affects >15 % of couples worldwide, birth rate is decreasing. Environmental factors are some most important causes infertility. However, little known effects MPs NPs on testes ovaries. These particles can enter body primarily via ingestion, inhalation, skin contact, target system a size-dependent manner disturb germ cell other somatic development. Our study systematically reviewed adverse plastic function offers valuable insights into different stages cells mechanisms. synergistic these carried contaminants was summarized. Given limited research scale, shift toward innovative technologies adoption multiple omics recommended for advancing related studies. Further needed explore based size, polymer type, shape, toxins, establish effective protective measures, develop precision medicine targeted damage.
Language: Английский
Citations
38
Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(23), P. 64342 - 64351
Published: April 17, 2023
Language: Английский
Citations
27
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170543 - 170543
Published: Feb. 1, 2024
Language: Английский
Citations
9
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: April 5, 2024
Abstract Plastic pollution is a pressing global issue, with over 400 million tons produced annually and projections of 1.1 billion by 2050. Microplastics (MPs), ranging from 5 mm to 1 µm, are pervasive in the environment. They found air, sea, freshwater, soils, food chains studies show that tiny MPs, smaller than 10 μm, can cross cellular membranes, posing potential health risks through oxidative stress, inflammation, immune dysfunction, neurotoxicity reprotoxicity. In recent years, research has shown microplastics have negative effects on female reproductive systems animals. However, there still lack evidence how accumulation affects human females. This study aimed examine presence ovarian follicular fluid 18 women undergoing assisted treatment whose samples were processed using patented method endorsed nationally internationally. particles <10 µm measured SEM EDX detection. Preventive measures taken avoid contamination during process. (dimensions µm) detected 14 out fluid, an average 2191 p/ml (0 - 7181p/ml) mean diameter MPs 4.48 (3.18-5.54 µm). A significant correlation was between microplastic concentration FSH (p-value <0.05), as well weak BMI, age Estradiol. There no fertilization outcomes, miscarriages, or live birth. first provide for microplastics’ treatment, representing threat function. Figure
Language: Английский
Citations
9
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113730 - 113730
Published: Sept. 21, 2022
Endocrine-disrupting chemicals (EDCs) are common in the environment and everyday products such as cosmetics, plastic food packaging, medicines. These substances toxic small doses (even order of micrograms) enter body through skin, digestive or respiratory system. Numerous studies confirm negative impact EDCs on living organisms. They disrupt endocrine functions, contributing to development neoplastic neurological diseases, well problems with circulatory system reproduction. affect humans animals by modulating epigenetic processes that can lead disturbances gene expression failure even death. also steroid hormones binding their receptors interfering synthesis secretion hormones. Prenatal exposure may be related offspring, resulting effects these ovaries leading reduction fertility function steroidogenesis gametogenesis. Current literature indicates need continue research female reproductive The aim this review was identify endocrine-disrupting genetic based recent literature.
Language: Английский
Citations
30
Chemosphere, Journal Year: 2023, Volume and Issue: 330, P. 138727 - 138727
Published: April 20, 2023
Endocrine-disrupting chemicals (EDCs) are a group of the most widely spread pollutants. Their impacts on reproductive health have become public concerns. Diminished ovarian reserve (DOR) is disorder function. Associations between EDC and DOR been inconsistent. Very little research investigated joint effects multiple EDCs. Here, we performed case-control study among 64 women 86 controls. Twenty-one were assessed in follicular fluid, including parabens, phenols, phthalates poly-fluoroalkyl substances. Both mixed single EDCs evaluated validated with Bayesian kernel machine logistic regressions. We found that likelihood significantly increased rising levels 21-EDC mixture, an odds ratio (OR) 95% confidence interval (CI) 2.12 (1.17-3.83) for 75th percentile compared to its median level. The overall effect was higher than each subgroup. BP4, MECPP, PFHxA driving association their validated, individual ORs 8.25 (95%CI:3.45-12.21), 1.92 (95%CI:1.02-4.09), 1.84 (95%CI:1.08-3.86), respectively. In conclusion, provided new pollutant markers emphasized importance mixtures female health.
Language: Английский
Citations
17
Microchemical Journal, Journal Year: 2024, Volume and Issue: 199, P. 109968 - 109968
Published: Jan. 14, 2024
Language: Английский
Citations
8